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PERTUSSIS ANTITOXIN

PERTUSSIS ANTITOXIN A previous paper1 reported on the preparation of pertussis toxin, its biologic effect in animals and the results of intradermal tests with this material in children. The work reported in the present article was an attempt to demonstrate neutralizing antibodies against pertussis toxin in the serum of children with whooping cough and of children immunized against the disease. The final criterion in judging the value of vaccine prophylaxis remains the observation of immunized children actively exposed to pertussis. Serologic tests are less time consuming than this method and have a definite advantage to the statistical approach. If it could be shown that a certain titer of pertussis antitoxin in the serum of exposed children protects against clinical infection, such a laboratory method would be of decided benefit in evaluating vaccine prophylaxis. The antigenicity of pertussis toxin has been investigated by various authors. While Bordet and Gengou2 failed to http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American journal of diseases of children American Medical Association

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Publisher
American Medical Association
Copyright
Copyright © 1942 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
0096-8994
eISSN
1538-3628
DOI
10.1001/archpedi.1942.02010070002001
Publisher site
See Article on Publisher Site

Abstract

A previous paper1 reported on the preparation of pertussis toxin, its biologic effect in animals and the results of intradermal tests with this material in children. The work reported in the present article was an attempt to demonstrate neutralizing antibodies against pertussis toxin in the serum of children with whooping cough and of children immunized against the disease. The final criterion in judging the value of vaccine prophylaxis remains the observation of immunized children actively exposed to pertussis. Serologic tests are less time consuming than this method and have a definite advantage to the statistical approach. If it could be shown that a certain titer of pertussis antitoxin in the serum of exposed children protects against clinical infection, such a laboratory method would be of decided benefit in evaluating vaccine prophylaxis. The antigenicity of pertussis toxin has been investigated by various authors. While Bordet and Gengou2 failed to

Journal

American journal of diseases of childrenAmerican Medical Association

Published: Jul 1, 1942

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