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Persistent Asymptomatic Nodules on the Legs

Persistent Asymptomatic Nodules on the Legs Abstract REPORT OF A CASE A 53-year-old woman presented with five, nontender, asymptomatic, brownish nodules (10 to 30 mm) on the anterior aspect of her legs. Four were on the left pretibial area and one was on the right (Fig 1). These nodules were gradual in onset and had been enlarging for several weeks.She had rheumatic fever when she was 18 years old. Type II diabetes mellitus and essential hypertension were diagnosed 1 year before. She also reported an acute episode of tachycardia, diffuse sweating, asthenia, and heat intolerance 9 months before, at which time a diagnosis of Graves-Basedow disease was established. At the time of presentation, the patient was receiving propranolol, carbimazole, and sulfonylurea.In addition to the cutaneous lesions, the patient presented with a diffuse, palpable goiter; her blood pressure was 130/70 mm Hg and her pulse rate was 120 beats per minute. The chest roentgenogram revealed References 1. Truhan AP, Roenigk HH. The cutaneous mucinosis . J Am Acad Dermatol. 1986;14:1-18Crossref 2. Roberts SOB, Weismann K. The skin in systemic disease . In: Rook A, Wilkinson, DS, Ebling FJG, et al. Textbook of Dermatology , 4th ed. Boston, Mass: Blackwell Scientific Publications Inc; 1986:2346. 3. Lynch PJ, Maize JC, Sisson JC. Pretibial myxedema and nonthyrotoxic thyroid disease . Arch Dermatol. 1973;107:107-111Crossref 4. Noppakun N, Bancheun K, Chandrapraset S. Unusual localizations of localized myxedema in Graves' disease: report of three cases . Arch Dermatol. 1986;122:85-88Crossref 5. Worstman J, Dietrich J, Traycoff RB, Stone S. Preradial myxedema in thyroid disease . Arch Dermatol. 1981;117:635-638.Crossref 6. Horiuchi Y. Pretibial myxedema associated with chronic thyroiditis . Arch Dermatol. 1985;121:451.Crossref 7. Cheung HS, Nicoloff JT, Kamiel MB, et al. Stimulation of fibroblast biosynthetic activity by serum of patients with pretibial myxedema . J Invest Dermatol. 1978;71:12-17.Crossref 8. Schermer DR, Roenigk HH, Schumacher OP, McKenzie JM. Relationship of long-acting thyroid stimulator to pretibial myxedema . Arch Dermatol. 1970;102:62-67.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology American Medical Association

Persistent Asymptomatic Nodules on the Legs

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Publisher
American Medical Association
Copyright
Copyright © 1993 American Medical Association. All Rights Reserved.
ISSN
0003-987X
eISSN
1538-3652
DOI
10.1001/archderm.1993.01680240109019
Publisher site
See Article on Publisher Site

Abstract

Abstract REPORT OF A CASE A 53-year-old woman presented with five, nontender, asymptomatic, brownish nodules (10 to 30 mm) on the anterior aspect of her legs. Four were on the left pretibial area and one was on the right (Fig 1). These nodules were gradual in onset and had been enlarging for several weeks.She had rheumatic fever when she was 18 years old. Type II diabetes mellitus and essential hypertension were diagnosed 1 year before. She also reported an acute episode of tachycardia, diffuse sweating, asthenia, and heat intolerance 9 months before, at which time a diagnosis of Graves-Basedow disease was established. At the time of presentation, the patient was receiving propranolol, carbimazole, and sulfonylurea.In addition to the cutaneous lesions, the patient presented with a diffuse, palpable goiter; her blood pressure was 130/70 mm Hg and her pulse rate was 120 beats per minute. The chest roentgenogram revealed References 1. Truhan AP, Roenigk HH. The cutaneous mucinosis . J Am Acad Dermatol. 1986;14:1-18Crossref 2. Roberts SOB, Weismann K. The skin in systemic disease . In: Rook A, Wilkinson, DS, Ebling FJG, et al. Textbook of Dermatology , 4th ed. Boston, Mass: Blackwell Scientific Publications Inc; 1986:2346. 3. Lynch PJ, Maize JC, Sisson JC. Pretibial myxedema and nonthyrotoxic thyroid disease . Arch Dermatol. 1973;107:107-111Crossref 4. Noppakun N, Bancheun K, Chandrapraset S. Unusual localizations of localized myxedema in Graves' disease: report of three cases . Arch Dermatol. 1986;122:85-88Crossref 5. Worstman J, Dietrich J, Traycoff RB, Stone S. Preradial myxedema in thyroid disease . Arch Dermatol. 1981;117:635-638.Crossref 6. Horiuchi Y. Pretibial myxedema associated with chronic thyroiditis . Arch Dermatol. 1985;121:451.Crossref 7. Cheung HS, Nicoloff JT, Kamiel MB, et al. Stimulation of fibroblast biosynthetic activity by serum of patients with pretibial myxedema . J Invest Dermatol. 1978;71:12-17.Crossref 8. Schermer DR, Roenigk HH, Schumacher OP, McKenzie JM. Relationship of long-acting thyroid stimulator to pretibial myxedema . Arch Dermatol. 1970;102:62-67.Crossref

Journal

Archives of DermatologyAmerican Medical Association

Published: Mar 1, 1993

References