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Peripheral Retinal Neovascularization With Chronic Myelogenous Leukemia

Peripheral Retinal Neovascularization With Chronic Myelogenous Leukemia Abstract A 30-year-old Negro man presented with a subhyaloid and vitreous hemorrhage in the left eye. He had chronic myelogenous leukemia of four years' duration but had been untreated for the past year. The peripheral leukocyte count was 250,000/cu mm. Neovascular tufts arose from retinal arteriovenous shunts just anterior to the equator in the superior and temporal quadrants of both eyes. These extended into the vitreous, accompanied by fibrous proliferation. They resembled the proliferative fibrovascular lesions ("sea fans") seen in hemoglobin sickle cell-hemoglobin C retinopathy. This patient's hemoglobin was AA, however. He had no evidence of occlusive vascular disease, and the protein electrophoretic pattern and results of a glucose tolerance test were normal. Retinal neovascularization has not previously been reported as a consequence of leukemia. References 1. Liebreich R: Atlas der Ophthalmoscopie . Berlin, August Hirschwald, 1863, p 29, plate 10. 2. Leber T: Die Krankheiten der Netzhaut: III. Die Erkrankungen der Netzhaut bei Leukamie und Pseudoleukamie , in Graefe-Saemisch's Handbuch der gesamten Augenheilkunde . Leipzig: Wilhelm Engelmann, 1916, vol 2, p 973. 3. Moore RF: Medical Ophthlamology . London: J & A Churchill, 1922, pp 70-73. 4. Borgeson EJ, Wagener HP: Changes in the eye in leukemia . Amer J Med Sci 177:663-676, 1929.Crossref 5. Allen RA, Straatsma BR: Ocular involvement in leukemia and allied disorders . Arch Ophthal 66:490-508, 1961.Crossref 6. Mahneke A, Videbaek A: On the changes in the optic fundus in leukemia . Acta Ophthal 42:201-210, 1964.Crossref 7. Holt JM, Gordon-Smith EC: Retinal abnormalitiesases of the blood . Brit J Ophthal 53:145-160, 1969.Crossref 8. Welch RB, Goldberg MF: Sickle-cell hemoglobin and its relation to fundus abnormality . Arch Ophthal 75:353-362, 1966.Crossref 9. Goodman G, von Sallmann L, Holland MC: Ocular manifestations of sickle-cell disease . Arch Ophthal 58:655-682, 1957.Crossref 10. Goldberg MF: Classification and pathogenesis of proliferative sickle retinopathy . Amer J Ophthal 71:649-655, 1971. 11. Paton D: The conjunctival sign of sickle-cell disease: Further observations . Arch Ophthal 68:627-632, 1962.Crossref 12. Nowell PC, Hungerford DA: Chromosome studies in human leukemia: II. Chronic granulocytic leukemia . J Nat Cancer Inst 27:1013-1035, 1961. 13. Wise GN: Retinal neovascularization . Trans Amer Ophthal Soc 54:729-826, 1956. 14. Andersson B, Samuelson A: A case of hyperglobulinemia with pronounced eye changes and acrocyanosis . Acta Med Scand 117:248-260, 1944.Crossref 15. Carr RE, Henkind P: Retinal findings associated with serum hyperviscosity . Amer J Ophthal 56:23-31, 1963. 16. Nagy F: Changes in the fundus caused by polycythemia . Brit J Ophthal 34:380-384, 1950.Crossref 17. Duke JR, Wilkinson CP, Sigelman S: Retinal microaneurysms in leukemia . Brit J Ophthal 52:368-374, 1968.Crossref 18. Podos SM, Canellos GP: Lens changes in chronic granulocytic leukemia . Amer J Ophthal 68: 500-504, 1969. 19. Morse PH, McCready JL: Retinal neovascularization in leukemia. Amer J Ophthal, to be published. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Ophthalmology American Medical Association

Peripheral Retinal Neovascularization With Chronic Myelogenous Leukemia

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Publisher
American Medical Association
Copyright
Copyright © 1972 American Medical Association. All Rights Reserved.
ISSN
0003-9950
eISSN
1538-3687
DOI
10.1001/archopht.1972.01000020587017
Publisher site
See Article on Publisher Site

Abstract

Abstract A 30-year-old Negro man presented with a subhyaloid and vitreous hemorrhage in the left eye. He had chronic myelogenous leukemia of four years' duration but had been untreated for the past year. The peripheral leukocyte count was 250,000/cu mm. Neovascular tufts arose from retinal arteriovenous shunts just anterior to the equator in the superior and temporal quadrants of both eyes. These extended into the vitreous, accompanied by fibrous proliferation. They resembled the proliferative fibrovascular lesions ("sea fans") seen in hemoglobin sickle cell-hemoglobin C retinopathy. This patient's hemoglobin was AA, however. He had no evidence of occlusive vascular disease, and the protein electrophoretic pattern and results of a glucose tolerance test were normal. Retinal neovascularization has not previously been reported as a consequence of leukemia. References 1. Liebreich R: Atlas der Ophthalmoscopie . Berlin, August Hirschwald, 1863, p 29, plate 10. 2. Leber T: Die Krankheiten der Netzhaut: III. Die Erkrankungen der Netzhaut bei Leukamie und Pseudoleukamie , in Graefe-Saemisch's Handbuch der gesamten Augenheilkunde . Leipzig: Wilhelm Engelmann, 1916, vol 2, p 973. 3. Moore RF: Medical Ophthlamology . London: J & A Churchill, 1922, pp 70-73. 4. Borgeson EJ, Wagener HP: Changes in the eye in leukemia . Amer J Med Sci 177:663-676, 1929.Crossref 5. Allen RA, Straatsma BR: Ocular involvement in leukemia and allied disorders . Arch Ophthal 66:490-508, 1961.Crossref 6. Mahneke A, Videbaek A: On the changes in the optic fundus in leukemia . Acta Ophthal 42:201-210, 1964.Crossref 7. Holt JM, Gordon-Smith EC: Retinal abnormalitiesases of the blood . Brit J Ophthal 53:145-160, 1969.Crossref 8. Welch RB, Goldberg MF: Sickle-cell hemoglobin and its relation to fundus abnormality . Arch Ophthal 75:353-362, 1966.Crossref 9. Goodman G, von Sallmann L, Holland MC: Ocular manifestations of sickle-cell disease . Arch Ophthal 58:655-682, 1957.Crossref 10. Goldberg MF: Classification and pathogenesis of proliferative sickle retinopathy . Amer J Ophthal 71:649-655, 1971. 11. Paton D: The conjunctival sign of sickle-cell disease: Further observations . Arch Ophthal 68:627-632, 1962.Crossref 12. Nowell PC, Hungerford DA: Chromosome studies in human leukemia: II. Chronic granulocytic leukemia . J Nat Cancer Inst 27:1013-1035, 1961. 13. Wise GN: Retinal neovascularization . Trans Amer Ophthal Soc 54:729-826, 1956. 14. Andersson B, Samuelson A: A case of hyperglobulinemia with pronounced eye changes and acrocyanosis . Acta Med Scand 117:248-260, 1944.Crossref 15. Carr RE, Henkind P: Retinal findings associated with serum hyperviscosity . Amer J Ophthal 56:23-31, 1963. 16. Nagy F: Changes in the fundus caused by polycythemia . Brit J Ophthal 34:380-384, 1950.Crossref 17. Duke JR, Wilkinson CP, Sigelman S: Retinal microaneurysms in leukemia . Brit J Ophthal 52:368-374, 1968.Crossref 18. Podos SM, Canellos GP: Lens changes in chronic granulocytic leukemia . Amer J Ophthal 68: 500-504, 1969. 19. Morse PH, McCready JL: Retinal neovascularization in leukemia. Amer J Ophthal, to be published.

Journal

Archives of OphthalmologyAmerican Medical Association

Published: May 1, 1972

References

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