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Perifollicular Hypopigmentation: A Cause of Variegate Pigmentation and Irregular Border in Melanocytic Nevi

Perifollicular Hypopigmentation: A Cause of Variegate Pigmentation and Irregular Border in... Abstract • Background and Design.— Clinical and histologic features of perifollicular hypopigmentation within melanocytic nevi are described. Results.— Perifollicular hypopigmentation was observed in congenital and acquired melanocytic nevi. When the area of hypopigmentation was found within the nevus, it was circular. When the hypopigmentation was located at the edge of the nevus, however, it formed a half circle that resulted in a notch in the outline of the lesion. The phenomenon occurred in nevi with terminal hairs as well as nevi with vellus hairs. In biopsy specimens from 15 melanocytic nevi, one or more of the following findings were observed around hair follicles when compared with the remainder of the nevus: decrease in the number of junctional melanocytes as nests and solitary units (n =12), decrease in pigment within keratinocytes (n = 14), decrease in the number of melanocytes in the papillary dermis (n = 6), and decrease in the number of melanophages (n = 6). Conclusions.— Perifollicular hypopigmentation is a cause of variegate pigmentation and irregular border in melanocytic nevi.(Arch Dermatol. 1992;128:514-517) References 1. Greene MH, Clark WH Jr, Tucker MA, et al. Acquired precursors of cutaneous malignant melanoma: the familial dysplastic nevus syndrome . N Engl J Med. 1985;312:91-97.Crossref 2. Kopf AW, Friedman RJ, Rigel DS. Atypical mole syndrome . J Am Acad Dermatol. 1990;22:117-118.Crossref 3. Friedman RJ, Rigel DS, Silverman MK, Kopf AW, Vossaert KA. Malignant melanoma in the 1990s: the continued importance of early detection and the role of physician examination and self-examination of the skin . CA . 1991;41:201-226. 4. Mihm MC, Fitzpatrick TB, Lane Brown MM, Raker JW, Malt RA, Kaiser JS. Early detection of primary cutaneous malignant melanoma: a color atlas . N Engl J Med. 1973;289:989-996.Crossref 5. Barnhill RL, Roush GC. Correlation of clinical and histopathologic features in clinically atypical melanocytic nevi . Cancer . 1991;67:3157-3164.Crossref 6. Maize JC, Ackerman AB. Benign proliferations of melanocytes . Pigmented Lesions of the Skin . Philadelphia, Pa: Lea & Febiger; 1987:114-130. 7. Brinn NT. Rapid metallic staining using the microwave oven . J Histotechnol . 1983;6:125-129.Crossref 8. Sober AJ, Fitzpatrick TB, Mihm MC, et al. Early recognition of cutaneous melanoma . JAMA . 1979;242:2795-2799.Crossref 9. Kelly JW, Crutcher WA, Sagebiel RW. Clinical diagnosis of dysplastic melanocytic nevi: a clinicopathologic correlation . J Am Acad Dermatol. 1986;14:1044-1052.Crossref 10. Wilson PD, Kligman AM. Experimental induction of freckles by ultraviolet-B . Br J Dermatol. 1982;106:401-406.Crossref 11. Morishima T, Endo M, Imagawa I, Morioka S. Clinical and histopathological studies on spotted grouped pigmented nevi with special reference to eccrine-centered nevus . Acta Derm Venereol. 1976;56:345-351. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology American Medical Association

Perifollicular Hypopigmentation: A Cause of Variegate Pigmentation and Irregular Border in Melanocytic Nevi

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Publisher
American Medical Association
Copyright
Copyright © 1992 American Medical Association. All Rights Reserved.
ISSN
0003-987X
eISSN
1538-3652
DOI
10.1001/archderm.1992.01680140094010
Publisher site
See Article on Publisher Site

Abstract

Abstract • Background and Design.— Clinical and histologic features of perifollicular hypopigmentation within melanocytic nevi are described. Results.— Perifollicular hypopigmentation was observed in congenital and acquired melanocytic nevi. When the area of hypopigmentation was found within the nevus, it was circular. When the hypopigmentation was located at the edge of the nevus, however, it formed a half circle that resulted in a notch in the outline of the lesion. The phenomenon occurred in nevi with terminal hairs as well as nevi with vellus hairs. In biopsy specimens from 15 melanocytic nevi, one or more of the following findings were observed around hair follicles when compared with the remainder of the nevus: decrease in the number of junctional melanocytes as nests and solitary units (n =12), decrease in pigment within keratinocytes (n = 14), decrease in the number of melanocytes in the papillary dermis (n = 6), and decrease in the number of melanophages (n = 6). Conclusions.— Perifollicular hypopigmentation is a cause of variegate pigmentation and irregular border in melanocytic nevi.(Arch Dermatol. 1992;128:514-517) References 1. Greene MH, Clark WH Jr, Tucker MA, et al. Acquired precursors of cutaneous malignant melanoma: the familial dysplastic nevus syndrome . N Engl J Med. 1985;312:91-97.Crossref 2. Kopf AW, Friedman RJ, Rigel DS. Atypical mole syndrome . J Am Acad Dermatol. 1990;22:117-118.Crossref 3. Friedman RJ, Rigel DS, Silverman MK, Kopf AW, Vossaert KA. Malignant melanoma in the 1990s: the continued importance of early detection and the role of physician examination and self-examination of the skin . CA . 1991;41:201-226. 4. Mihm MC, Fitzpatrick TB, Lane Brown MM, Raker JW, Malt RA, Kaiser JS. Early detection of primary cutaneous malignant melanoma: a color atlas . N Engl J Med. 1973;289:989-996.Crossref 5. Barnhill RL, Roush GC. Correlation of clinical and histopathologic features in clinically atypical melanocytic nevi . Cancer . 1991;67:3157-3164.Crossref 6. Maize JC, Ackerman AB. Benign proliferations of melanocytes . Pigmented Lesions of the Skin . Philadelphia, Pa: Lea & Febiger; 1987:114-130. 7. Brinn NT. Rapid metallic staining using the microwave oven . J Histotechnol . 1983;6:125-129.Crossref 8. Sober AJ, Fitzpatrick TB, Mihm MC, et al. Early recognition of cutaneous melanoma . JAMA . 1979;242:2795-2799.Crossref 9. Kelly JW, Crutcher WA, Sagebiel RW. Clinical diagnosis of dysplastic melanocytic nevi: a clinicopathologic correlation . J Am Acad Dermatol. 1986;14:1044-1052.Crossref 10. Wilson PD, Kligman AM. Experimental induction of freckles by ultraviolet-B . Br J Dermatol. 1982;106:401-406.Crossref 11. Morishima T, Endo M, Imagawa I, Morioka S. Clinical and histopathological studies on spotted grouped pigmented nevi with special reference to eccrine-centered nevus . Acta Derm Venereol. 1976;56:345-351.

Journal

Archives of DermatologyAmerican Medical Association

Published: Apr 1, 1992

References

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