Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Penicillin Treatment of Streptococcal Pharyngitis

Penicillin Treatment of Streptococcal Pharyngitis Abstract Sir.—We would like to congratulate Gerber et al1 on their careful collection of data comparing BID and TID penicillin therapies for group A β-hemolytic streptococcal pharyngitis. However, the analysis of those data was incomplete and it therefore misled the authors into making improper conclusions. Their data showed a difference in failure rates of 28% vs 18% in favor of TID therapy. However, this difference was not statistically significant by the χ2 test (P=.21), and the authors concluded that the investigation suggested "that oral penicillin V given twice daily is as effective as penicillin V given three times daily." The P value cited here only indicates the likelihood of type I or α error: the probability of accepting two forms of therapy as different when, in fact, they are the same. That is, these data do not permit the conclusion that the two treatments are different, for References 1. Gerber MA, Spadaccini LJ, Wright LL, et al: Twice-daily penicillin in the treatment of streptococcal pharyngitis . AJDC 1985;139:1145-1148. 2. Freiman JA, Chalmers TC, Smith H Jr, et al: The importance of beta, the type II error, and sample size in the design and interpretation of the randomized control trial . N Engl J Med 1978;299:690-694.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Diseases of Children American Medical Association

Penicillin Treatment of Streptococcal Pharyngitis

Penicillin Treatment of Streptococcal Pharyngitis

Abstract

Abstract Sir.—We would like to congratulate Gerber et al1 on their careful collection of data comparing BID and TID penicillin therapies for group A β-hemolytic streptococcal pharyngitis. However, the analysis of those data was incomplete and it therefore misled the authors into making improper conclusions. Their data showed a difference in failure rates of 28% vs 18% in favor of TID therapy. However, this difference was not statistically significant by the χ2 test (P=.21), and...
Loading next page...
 
/lp/american-medical-association/penicillin-treatment-of-streptococcal-pharyngitis-bwKnppPysn
Publisher
American Medical Association
Copyright
Copyright © 1986 American Medical Association. All Rights Reserved.
ISSN
0002-922X
DOI
10.1001/archpedi.1986.02140190019010
Publisher site
See Article on Publisher Site

Abstract

Abstract Sir.—We would like to congratulate Gerber et al1 on their careful collection of data comparing BID and TID penicillin therapies for group A β-hemolytic streptococcal pharyngitis. However, the analysis of those data was incomplete and it therefore misled the authors into making improper conclusions. Their data showed a difference in failure rates of 28% vs 18% in favor of TID therapy. However, this difference was not statistically significant by the χ2 test (P=.21), and the authors concluded that the investigation suggested "that oral penicillin V given twice daily is as effective as penicillin V given three times daily." The P value cited here only indicates the likelihood of type I or α error: the probability of accepting two forms of therapy as different when, in fact, they are the same. That is, these data do not permit the conclusion that the two treatments are different, for References 1. Gerber MA, Spadaccini LJ, Wright LL, et al: Twice-daily penicillin in the treatment of streptococcal pharyngitis . AJDC 1985;139:1145-1148. 2. Freiman JA, Chalmers TC, Smith H Jr, et al: The importance of beta, the type II error, and sample size in the design and interpretation of the randomized control trial . N Engl J Med 1978;299:690-694.Crossref

Journal

American Journal of Diseases of ChildrenAmerican Medical Association

Published: May 1, 1986

References