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Penicillin Treatment of Asymptomatic Central Nervous System Syphilis: II. Results of Therapy as Measured by Laboratory Findings

Penicillin Treatment of Asymptomatic Central Nervous System Syphilis: II. Results of Therapy as... Abstract During the past several years, the Venereal Disease Program, in cooperation with a number of well-known clinics and hospitals throughout the country, has conducted a study to determine the effectiveness of penicillin in the treatment of asymptomatic neurosyphilis. A preceding report1 has shown that factors such as age, race, sex, previous treatment, and re-treatment status have little or no relationship to clinical prognosis in penicillin-treated asymptomatic central nervous system (CNS) syphilis. The present report deals with the pretreatment and post-treatment status of the patient group in terms of results of blood and spinal fluid examinations. This study consists of 765 patients with asymptomatic neurosyphilis, whose histories were selected from the records of eight cooperating clinics in accordance with the following criteria: (1) reactive spinal fluid, i.e., abnormalities in the spinal fluid test for syphilis, colloidal test, total protein, or cell count, or References 1. Defined as a minimum of 20 arsenical injections and 20 heavy-metal injections. 2. Hahn, R. D., and others: Penicillin Treatment of Neurosyphilis: I. Probability of Progression to Symptomatic Neurosyphilis , A. M. A. Arch. Dermat. , this issue, p. 355. 3. Laboratory Manual for Physicians , Ed. 10, New York State Department of Health, Division of Laboratories and Research , Albany, N. Y., 1951. 4. Kolmer, J. A.: Serum Diagnosis by Complement Fixation with Special Reference to Syphilis , Philadelphia, Lea & Febiger, 1928. 5. Manual of Serologic Tests for Syphilis , (Supp. 22) , J. Ven. Dis. Inform. , 1949. 6. Kolmer, J. A., and Boerner, F.: Approved Laboratory Technic , Ed. 4, New York, D. Appleton-Century Company, Inc., 1945. 7. Manual for Use of the Klett-Summerson Photoelectric Colorimeter (Analytical Procedure), New York, Klett Manufacturing Company. 8. Kahn, R. L.: Technique of the Standard Kahn Test and of Special Kahn Procedures , revised and enlarged edition, Ann Arbor, University of Michigan Press, 1945. 9. Clark, T.; Parran, T., Jr.; Cole, H. N.; Moore, J. E.; O'Leary, P. A.; Stokes, J. H., and Wile, U. J.: Cooperative Clinical Studies in the Treatment of Syphilis , Ven. Dis. Inform. 13:135-139; 165-182; 207-231; 253-293, 1932. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png A.M.A. Archives of Dermatology American Medical Association

Penicillin Treatment of Asymptomatic Central Nervous System Syphilis: II. Results of Therapy as Measured by Laboratory Findings

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Publisher
American Medical Association
Copyright
Copyright © 1956 American Medical Association. All Rights Reserved.
ISSN
0096-5359
DOI
10.1001/archderm.1956.01550100035007
Publisher site
See Article on Publisher Site

Abstract

Abstract During the past several years, the Venereal Disease Program, in cooperation with a number of well-known clinics and hospitals throughout the country, has conducted a study to determine the effectiveness of penicillin in the treatment of asymptomatic neurosyphilis. A preceding report1 has shown that factors such as age, race, sex, previous treatment, and re-treatment status have little or no relationship to clinical prognosis in penicillin-treated asymptomatic central nervous system (CNS) syphilis. The present report deals with the pretreatment and post-treatment status of the patient group in terms of results of blood and spinal fluid examinations. This study consists of 765 patients with asymptomatic neurosyphilis, whose histories were selected from the records of eight cooperating clinics in accordance with the following criteria: (1) reactive spinal fluid, i.e., abnormalities in the spinal fluid test for syphilis, colloidal test, total protein, or cell count, or References 1. Defined as a minimum of 20 arsenical injections and 20 heavy-metal injections. 2. Hahn, R. D., and others: Penicillin Treatment of Neurosyphilis: I. Probability of Progression to Symptomatic Neurosyphilis , A. M. A. Arch. Dermat. , this issue, p. 355. 3. Laboratory Manual for Physicians , Ed. 10, New York State Department of Health, Division of Laboratories and Research , Albany, N. Y., 1951. 4. Kolmer, J. A.: Serum Diagnosis by Complement Fixation with Special Reference to Syphilis , Philadelphia, Lea & Febiger, 1928. 5. Manual of Serologic Tests for Syphilis , (Supp. 22) , J. Ven. Dis. Inform. , 1949. 6. Kolmer, J. A., and Boerner, F.: Approved Laboratory Technic , Ed. 4, New York, D. Appleton-Century Company, Inc., 1945. 7. Manual for Use of the Klett-Summerson Photoelectric Colorimeter (Analytical Procedure), New York, Klett Manufacturing Company. 8. Kahn, R. L.: Technique of the Standard Kahn Test and of Special Kahn Procedures , revised and enlarged edition, Ann Arbor, University of Michigan Press, 1945. 9. Clark, T.; Parran, T., Jr.; Cole, H. N.; Moore, J. E.; O'Leary, P. A.; Stokes, J. H., and Wile, U. J.: Cooperative Clinical Studies in the Treatment of Syphilis , Ven. Dis. Inform. 13:135-139; 165-182; 207-231; 253-293, 1932.

Journal

A.M.A. Archives of DermatologyAmerican Medical Association

Published: Oct 1, 1956

References