Abstract So much attention has been centered on penicillin therapy of asymptomatic syphilis and efforts to stabilize and streamline it, that the use of this new type of treatment for late latent syphilis has been relegated to the background. This subject was undertaken in order to determine, among other objectives, the therapeutic value of penicillin in late latent syphilis cases as to the outcome of serologic tests. A review of the recent annual reports of the Philadelphia Department of Public Health reveals that late latent syphilis comprises better than one-half of the total syphilis cases reported. For the purpose of this paper late latent syphilis is defined as asymptomatic syphilis of more than four years' duration with no clinical or laboratory evidence except a positive blood serologic test. There are many reasons for this apparent lack of interest in the treatment of late latent syphilis with penicillin since opinions vary References 1. PAM is used to designate procaine penicillin G containing 2% (w/O) aluminum monostearate in sesame oil 300,000 units per cubic centimeter. 2. Kaplan, B. I.: Long Term Results of Therapy in Latent Syphilis , Paper read at the Symposium on Syphilis, Venereal Disease Control Center for Department of Health, Education, and Welfare, Regions I and II, Philadelphia, March 3, 1954 . 3. Moore, J. E.: Management of Syphilis in General Practice , J. Ven. Dis. Inform. ( (Supp. 23) ), pp. 21-23, 1949. 4. Usilton, L. J., and Miner, J. R.: A Tentative Death Curve for Acquired Syphilis in White and Colored Males in the United States , J. Ven. Dis. Inform. 18:231, 1937. 5. Black-Schaffer, B., and Rosahn, P. D.: Studies in Syphilis: Relation Between Blood Serologic Tests and Anatomic Lesions at Autopsy , Am. J. Syph. 28:27-43 ( (Jan.) ) 1944. 6. Jordan, J. W., and Dolce, F. A.: Latent Syphilis: A Study of 169 Cases Observed 10 Years or More , Arch. Dermat. & Syph. 54:1-18 ( (July) ) 1946. 7. Diseker, T. H.; Clark, E. G., and Moore, J. E.: Long-Term Results in the Treatment of Latent Syphilis , Am. J. Syph. 28:1-26 ( (Jan.) ) 1944. 8. Blum, H. L., and Barnett, C. W.: Prognosis in Late Latent Syphilis , Arch. Int. Med. 82:393-409 ( (Oct.) ) 1948. 9. Barnett, C. W.; Epstein, N. N.; Brewer, A. F.; Koch, R. A., and Beirne, G. A.: Effect of Treatment in Late Latent Syphilis , A. M. A. Arch. Dermat. & Syph. 69:91-99 ( (Jan.) ) 1954.
A.M.A. Archives of Dermatology – American Medical Association
Published: May 1, 1956