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PENICILLIN AS THROMBOPLASTIC AGENT

PENICILLIN AS THROMBOPLASTIC AGENT Abstract THE EFFECTS of penicillin administered parenterally on the clotting mechanism of blood is a controversial subject. In order to determine the efficacy of penicillin as a thromboplastic agent, this study was instituted. Many references concerning this subject are available in the literature. Fleming and Fish,1 in 1947, did a series of experiments in vitro testing the coagulating property of penicillin. Their conclusion had little bearing on the clinical and systemic use of penicillin. They demonstrated that in vitro and locally penicillin had no effect on the clotting mechanism of blood. Moldavsky2 and his associates, in 1945, tested the same properties of penicillin on patients, administering the drug orally and intramuscularly. Their conclusions apparently had considerable practical clinical significance. They found that (a) the clotting time of blood diminished as the level of penicillin rose in blood; (b) there was a decrease in the bleeding time with penicillin administration, References 1. Fleming, A., and Fish, E. W.: Influence of Penicillin on Coagulation of Blood: With Especial Reference to Certain Dental Operations , Brit. M. J. 2:242-243 ( (Aug. 16) ) 1947.Crossref 2. Moldavsky, L. F.; Hasslebrock, W. B., and Catena, C.: Studies in Mechanisms of Penicillin Action: Penicillin Effects on Blood Coagulation , Science 102:38-40 ( (July 13) ) 1945.Crossref 3. Kemler, I.: Influence of Penicillin on Epistaxis: A Preliminary Report , Eye, Ear, Nose, and Throat Month. 28:165-168 ( (April) ) 1949. 4. Peltz, M. D.: Penicillin as a Blood Coagulant, Correspondence , J. A. M. A. 134:207 ( (May 10) ) 1947.Crossref 5. Lewis, J. H.: Effect of Penicillin on Blood Coagulation , Proc. Soc. Exper. Biol. & Med. 63:538-540 ( (Dec.) ) 1946. 6. Macht, D. I.: Influence of Some Drugs and of Emotions on Blood Coagulation , J. A. M. A. 148:265-270 ( (Jan. 26) ) 1952. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png A.M.A. Archives of Otolaryngology American Medical Association

PENICILLIN AS THROMBOPLASTIC AGENT

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Publisher
American Medical Association
Copyright
Copyright © 1953 American Medical Association. All Rights Reserved.
ISSN
0096-6894
DOI
10.1001/archotol.1953.00710040289003
Publisher site
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Abstract

Abstract THE EFFECTS of penicillin administered parenterally on the clotting mechanism of blood is a controversial subject. In order to determine the efficacy of penicillin as a thromboplastic agent, this study was instituted. Many references concerning this subject are available in the literature. Fleming and Fish,1 in 1947, did a series of experiments in vitro testing the coagulating property of penicillin. Their conclusion had little bearing on the clinical and systemic use of penicillin. They demonstrated that in vitro and locally penicillin had no effect on the clotting mechanism of blood. Moldavsky2 and his associates, in 1945, tested the same properties of penicillin on patients, administering the drug orally and intramuscularly. Their conclusions apparently had considerable practical clinical significance. They found that (a) the clotting time of blood diminished as the level of penicillin rose in blood; (b) there was a decrease in the bleeding time with penicillin administration, References 1. Fleming, A., and Fish, E. W.: Influence of Penicillin on Coagulation of Blood: With Especial Reference to Certain Dental Operations , Brit. M. J. 2:242-243 ( (Aug. 16) ) 1947.Crossref 2. Moldavsky, L. F.; Hasslebrock, W. B., and Catena, C.: Studies in Mechanisms of Penicillin Action: Penicillin Effects on Blood Coagulation , Science 102:38-40 ( (July 13) ) 1945.Crossref 3. Kemler, I.: Influence of Penicillin on Epistaxis: A Preliminary Report , Eye, Ear, Nose, and Throat Month. 28:165-168 ( (April) ) 1949. 4. Peltz, M. D.: Penicillin as a Blood Coagulant, Correspondence , J. A. M. A. 134:207 ( (May 10) ) 1947.Crossref 5. Lewis, J. H.: Effect of Penicillin on Blood Coagulation , Proc. Soc. Exper. Biol. & Med. 63:538-540 ( (Dec.) ) 1946. 6. Macht, D. I.: Influence of Some Drugs and of Emotions on Blood Coagulation , J. A. M. A. 148:265-270 ( (Jan. 26) ) 1952.

Journal

A.M.A. Archives of OtolaryngologyAmerican Medical Association

Published: Sep 1, 1953

References