Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You and Your Team.

Learn More →

Penicillamine-Induced Pemphigus: Immunoglobulin From This Patient Induces Plasminogen Activator Synthesis by Human Epidermal Cells in Culture: Mechanism for Acantholysis in Pemphigus

Penicillamine-Induced Pemphigus: Immunoglobulin From This Patient Induces Plasminogen Activator... Abstract • The incubation of cultured epidermal cells with IgG obtained from a 56-year-old man with penicillamine-induced pemphigus resulted in an increase in extracellular and intracellular plasminogen activator. This suggests that penicillamine-induced pemphigus and spontaneously occurring pemphigus share common pathophysiologic processes in the induction of blister formation. (Arch Dermatol 1984;120:762-764) References 1. Degos R, Touraine R, Belaich S, et al: Pemphigus chez un malade traite par penicillamine pour maladie de Wilson . Bull Soc Fr Dermatol Syphilogr 1969;76:751-753. 2. Troy JL, Silvers DN, Grossman ME, et al: Penicillamine-associated pemphigus: Is it really pemphigus? J Am Acad Dermatol 1981;4:547-555.Crossref 3. DeJong M, Doeglas H, Dijkstra J: Immunohistochemical findings in a patient with penicillamine pemphigus . Br J Dermatol 1980;102:333-337.Crossref 4. Trau H, Schewack-Millet M, Gold I, et al: Penicillamine-induced pemphigus . Arch Dermatol 1980;116:721-722.Crossref 5. Hashimoto K, Shafran KM, Webber PS, et al: Anti-cell surface pemphigus autoantibody stimulates plasminogen activator activity of human epidermal cells: A mechanism for the loss of epidermal cohesion and blister formation . J Exp Med 1983; 157:259-272.Crossref 6. Rheinwald JG, Green H: Serial cultivation of stains of human epidermal keratinocytes: The formation of keratinizing colonies from single cells . Cell 1975;6:331-344.Crossref 7. Becker D, Ossowski L, Reich E: Induction of plasminogen activator synthesis by antibodies . J Exp Med 1981;154:385-396.Crossref 8. Singer KH, Hashimoto K, Stuhlmiller GM, et al: Antibody-induced release of cellular proteinases . J Immunol 1982;128:1321-1326. 9. Hashimoto K, Singer K, Morioka S, et al: Plasminogen activator in cultured human epidermal cells , abstracted. Clin Res 1983;31:571a. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology American Medical Association

Penicillamine-Induced Pemphigus: Immunoglobulin From This Patient Induces Plasminogen Activator Synthesis by Human Epidermal Cells in Culture: Mechanism for Acantholysis in Pemphigus

Loading next page...
 
/lp/american-medical-association/penicillamine-induced-pemphigus-immunoglobulin-from-this-patient-YEv6HEv0BQ
Publisher
American Medical Association
Copyright
Copyright © 1984 American Medical Association. All Rights Reserved.
ISSN
0003-987X
eISSN
1538-3652
DOI
10.1001/archderm.1984.01650420072019
Publisher site
See Article on Publisher Site

Abstract

Abstract • The incubation of cultured epidermal cells with IgG obtained from a 56-year-old man with penicillamine-induced pemphigus resulted in an increase in extracellular and intracellular plasminogen activator. This suggests that penicillamine-induced pemphigus and spontaneously occurring pemphigus share common pathophysiologic processes in the induction of blister formation. (Arch Dermatol 1984;120:762-764) References 1. Degos R, Touraine R, Belaich S, et al: Pemphigus chez un malade traite par penicillamine pour maladie de Wilson . Bull Soc Fr Dermatol Syphilogr 1969;76:751-753. 2. Troy JL, Silvers DN, Grossman ME, et al: Penicillamine-associated pemphigus: Is it really pemphigus? J Am Acad Dermatol 1981;4:547-555.Crossref 3. DeJong M, Doeglas H, Dijkstra J: Immunohistochemical findings in a patient with penicillamine pemphigus . Br J Dermatol 1980;102:333-337.Crossref 4. Trau H, Schewack-Millet M, Gold I, et al: Penicillamine-induced pemphigus . Arch Dermatol 1980;116:721-722.Crossref 5. Hashimoto K, Shafran KM, Webber PS, et al: Anti-cell surface pemphigus autoantibody stimulates plasminogen activator activity of human epidermal cells: A mechanism for the loss of epidermal cohesion and blister formation . J Exp Med 1983; 157:259-272.Crossref 6. Rheinwald JG, Green H: Serial cultivation of stains of human epidermal keratinocytes: The formation of keratinizing colonies from single cells . Cell 1975;6:331-344.Crossref 7. Becker D, Ossowski L, Reich E: Induction of plasminogen activator synthesis by antibodies . J Exp Med 1981;154:385-396.Crossref 8. Singer KH, Hashimoto K, Stuhlmiller GM, et al: Antibody-induced release of cellular proteinases . J Immunol 1982;128:1321-1326. 9. Hashimoto K, Singer K, Morioka S, et al: Plasminogen activator in cultured human epidermal cells , abstracted. Clin Res 1983;31:571a.

Journal

Archives of DermatologyAmerican Medical Association

Published: Jun 1, 1984

References