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Pemphigus Vulgaris: A Correlation of Clinical and Microscopic Observations

Pemphigus Vulgaris: A Correlation of Clinical and Microscopic Observations Abstract The diagnosis of pemphigus vulgaris in the past has been based on the clinical features and the course of the disease. Recent reports have placed the microscopic findings ahead of the clinical ones in making the differential diagnosis. The object of the present report is to correlate clinical and microscopic characteristics of bullous eruptions considered to be in the pemphigus group. A number of authors have discussed the microscopic features and have attempted to reclassify the pemphigus group. In 1943, Civatte4 stressed the difference between dermatitis herpetiformis and pemphigus vulgaris on the basis of the microscopic picture of the bulla. According to him, the bulla of dermatitis herpetiformis is a tension type bulla located between the epidermis and the cutis in which the epithelial cells at the border of the bulla are stretched but firmly attached to one another. The bulla may contain References 1. References 1, 2, 3, 5, 6, 9, 11, 15, 16, and 19. 2. Hyman, A.: Paper read before the American Academy of Dermatology and Syphilology, December, 1953 . 3. References 5, 6, and 12. 4. References 5, 6, and 12. 5. Paper read before the American Academy of Dermatology and Syphilology, December, 1953 . 6. References 15 and 16. 7. Blank, H., and Burgoon, C. F.: Abnormal Cytology of Epithelial Cells in Pemphigus Vulgaris: A Diagnostic Aid , J. Invest. Dermat. 18:213-223 ( (March) ) 1952. 8. Brennan, J. G.: Contributions to the Study of Pemphigus , A. M. A. Arch. Dermat. & Syph. 68:481-498 ( (Nov.) ) 1953. 9. Brennan, J. G., and Montgomery, H.: Pemphigus and Other Bullous Dermatoses: Correlation of Clinical and Pathologic Findings , J. Invest. Dermat. 21:349-361 ( (Dec.) ) 1953. 10. Civatte, A.: Diagnostic histopathologique de la dermatite polymorphe douloureuse ou maladie de Duhring-Brocq , Ann. dermat. et syph. 3:1-30 ( (Jan.) -Feb.) 1943. 11. Director, W.: Pemphigus Vulgaris: A Clinicopathologic Study , A. M. A. Arch. Dermat. & Syph. 65:155-169 ( (Feb.) ) 1952. 12. Director, W.: Pemphigus Vegetans: A Clinicopathologic Correlation , A. M. A. Arch. Dermat. & Syph. 66:343-352 ( (Sept.) ) 1952. 13. Fisher, I.: Pemphigus: A Clinical and Laboratory Study , A. M. A. Arch. Dermat. & Syph. 66:49-58 ( (July) ) 1952. 14. Hellier, F. F.: Anomalous Histological Findings in Pemphigus , Brit. J. Dermat. 66:49-56 ( (Feb.) ) 1954. 15. Lever, W. F.: Pemphigus , Medicine 32:1 ( (Feb.) ) 1953. 16. Lever, W. F.: Oral Lesions in Pemphigus , Am. J. Orthodontics (Oral Surg. Sect.) 28:569-580 ( (Oct.) ) 1942. 17. Lever, W. F.: Pemphigus: A Histopathologic Study , A. M. A. Arch. Dermat. & Syph. 64:727-753 ( (Dec.) ) 1951. 18. Lever, W. F., and Talbott, J. H.: Pemphigus: A Further Report on Chemical Studies of the Blood Serum and Treatment with Adrenocortical Extract, Dihydrotachysterol or Vitamin D , New England J. Med. 231:44-51 ( (July 13) ) 1944. 19. Mian, E. U.: Cytologische Beobachtungen an bullösen Hauterscheinungen unter Verwendung der Phasenkontrastmikroskopie , Dermatologica 103:89-96, 1951. 20. Michelson, H. E.: Acute Forms of Pemphigus , A. M. A. Arch. Dermat. & Syph. 65422-428 ( (April) ) 1952. 21. Rook, A., and Waddington, E.: Pemphigus and Pemphigoid , Brit. J. Dermat. 65:425-431 ( (Dec.) ) 1953. 22. Rook, A. J., and Whimster, I. W.: The Histologic Diagnosis of Pemphigus , Brit. J. Dermat. 62:443-446 ( (Nov.) ) 1950. 23. Tzanck, A.: Le Cytodiagnostic immédiat en dermatologie , Ann. dermat. et syph. 8:205-218 ( (May) ) 1948. 24. Tzanck, A.; Melki, G. R., and Aron-Brunetiere, R.: The Cytodiagnosis of Pemphigus , Acta un. internat. cancr. 7:427-729, 1951. 25. Winer, L. H., and Lipschultz, C. E.: Comparative Study of Histology and Cytology in Vesiculating Eruptions , A. M. A. Arch. Dermat. & Syph. 65:270-290 ( (March) ) 1952. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png A.M.A. Archives of Dermatology American Medical Association

Pemphigus Vulgaris: A Correlation of Clinical and Microscopic Observations

A.M.A. Archives of Dermatology , Volume 74 (1) – Jul 1, 1956

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Publisher
American Medical Association
Copyright
Copyright © 1956 American Medical Association. All Rights Reserved.
ISSN
0096-5359
DOI
10.1001/archderm.1956.01550070052010
Publisher site
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Abstract

Abstract The diagnosis of pemphigus vulgaris in the past has been based on the clinical features and the course of the disease. Recent reports have placed the microscopic findings ahead of the clinical ones in making the differential diagnosis. The object of the present report is to correlate clinical and microscopic characteristics of bullous eruptions considered to be in the pemphigus group. A number of authors have discussed the microscopic features and have attempted to reclassify the pemphigus group. In 1943, Civatte4 stressed the difference between dermatitis herpetiformis and pemphigus vulgaris on the basis of the microscopic picture of the bulla. According to him, the bulla of dermatitis herpetiformis is a tension type bulla located between the epidermis and the cutis in which the epithelial cells at the border of the bulla are stretched but firmly attached to one another. The bulla may contain References 1. References 1, 2, 3, 5, 6, 9, 11, 15, 16, and 19. 2. Hyman, A.: Paper read before the American Academy of Dermatology and Syphilology, December, 1953 . 3. References 5, 6, and 12. 4. References 5, 6, and 12. 5. Paper read before the American Academy of Dermatology and Syphilology, December, 1953 . 6. References 15 and 16. 7. Blank, H., and Burgoon, C. F.: Abnormal Cytology of Epithelial Cells in Pemphigus Vulgaris: A Diagnostic Aid , J. Invest. Dermat. 18:213-223 ( (March) ) 1952. 8. Brennan, J. G.: Contributions to the Study of Pemphigus , A. M. A. Arch. Dermat. & Syph. 68:481-498 ( (Nov.) ) 1953. 9. Brennan, J. G., and Montgomery, H.: Pemphigus and Other Bullous Dermatoses: Correlation of Clinical and Pathologic Findings , J. Invest. Dermat. 21:349-361 ( (Dec.) ) 1953. 10. Civatte, A.: Diagnostic histopathologique de la dermatite polymorphe douloureuse ou maladie de Duhring-Brocq , Ann. dermat. et syph. 3:1-30 ( (Jan.) -Feb.) 1943. 11. Director, W.: Pemphigus Vulgaris: A Clinicopathologic Study , A. M. A. Arch. Dermat. & Syph. 65:155-169 ( (Feb.) ) 1952. 12. Director, W.: Pemphigus Vegetans: A Clinicopathologic Correlation , A. M. A. Arch. Dermat. & Syph. 66:343-352 ( (Sept.) ) 1952. 13. Fisher, I.: Pemphigus: A Clinical and Laboratory Study , A. M. A. Arch. Dermat. & Syph. 66:49-58 ( (July) ) 1952. 14. Hellier, F. F.: Anomalous Histological Findings in Pemphigus , Brit. J. Dermat. 66:49-56 ( (Feb.) ) 1954. 15. Lever, W. F.: Pemphigus , Medicine 32:1 ( (Feb.) ) 1953. 16. Lever, W. F.: Oral Lesions in Pemphigus , Am. J. Orthodontics (Oral Surg. Sect.) 28:569-580 ( (Oct.) ) 1942. 17. Lever, W. F.: Pemphigus: A Histopathologic Study , A. M. A. Arch. Dermat. & Syph. 64:727-753 ( (Dec.) ) 1951. 18. Lever, W. F., and Talbott, J. H.: Pemphigus: A Further Report on Chemical Studies of the Blood Serum and Treatment with Adrenocortical Extract, Dihydrotachysterol or Vitamin D , New England J. Med. 231:44-51 ( (July 13) ) 1944. 19. Mian, E. U.: Cytologische Beobachtungen an bullösen Hauterscheinungen unter Verwendung der Phasenkontrastmikroskopie , Dermatologica 103:89-96, 1951. 20. Michelson, H. E.: Acute Forms of Pemphigus , A. M. A. Arch. Dermat. & Syph. 65422-428 ( (April) ) 1952. 21. Rook, A., and Waddington, E.: Pemphigus and Pemphigoid , Brit. J. Dermat. 65:425-431 ( (Dec.) ) 1953. 22. Rook, A. J., and Whimster, I. W.: The Histologic Diagnosis of Pemphigus , Brit. J. Dermat. 62:443-446 ( (Nov.) ) 1950. 23. Tzanck, A.: Le Cytodiagnostic immédiat en dermatologie , Ann. dermat. et syph. 8:205-218 ( (May) ) 1948. 24. Tzanck, A.; Melki, G. R., and Aron-Brunetiere, R.: The Cytodiagnosis of Pemphigus , Acta un. internat. cancr. 7:427-729, 1951. 25. Winer, L. H., and Lipschultz, C. E.: Comparative Study of Histology and Cytology in Vesiculating Eruptions , A. M. A. Arch. Dermat. & Syph. 65:270-290 ( (March) ) 1952.

Journal

A.M.A. Archives of DermatologyAmerican Medical Association

Published: Jul 1, 1956

References