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Pediatric Seizure Drugs Tested

Pediatric Seizure Drugs Tested A study funded by the National Institute of Child Health and Human Development is designed to determine which of the 2 drugs commonly prescribed to treat status epilepticus in children is safer and more effective. Status epilepticus affects up to 8 in 1000 children before they reach age 15 years and is fatal in 4% of cases. The study will be conducted at 11 hospitals in which children presenting to the emergency departments with status epilepticus will be randomly assigned to either diazepam or lorazepam (http://www.nichd.nih.gov/news/releases/study_pediatric_seizure_QA_052207.cfm). Diazepam is approved for use in adults and children while lorazepam is approved for adults but is being used off label for children. As status epilepticus must be treated within 5 minutes of presentation in the emergency department to minimize the risk of brain injury or death, consent from a parent to enroll a child in the study will be sought after treatment. If a parent declines consent, the child will then be withdrawn from any further aspects of the study. Independent boards or research review committees at each hospital will oversee the study to ensure all procedures comply with ethics and safety standards. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA American Medical Association

Pediatric Seizure Drugs Tested

JAMA , Volume 297 (24) – Jun 27, 2007

Pediatric Seizure Drugs Tested

Abstract

A study funded by the National Institute of Child Health and Human Development is designed to determine which of the 2 drugs commonly prescribed to treat status epilepticus in children is safer and more effective. Status epilepticus affects up to 8 in 1000 children before they reach age 15 years and is fatal in 4% of cases. The study will be conducted at 11 hospitals in which children presenting to the emergency departments with status epilepticus will be randomly assigned to either diazepam...
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Publisher
American Medical Association
Copyright
Copyright © 2007 American Medical Association. All Rights Reserved.
ISSN
0098-7484
eISSN
1538-3598
DOI
10.1001/jama.297.24.2686-a
Publisher site
See Article on Publisher Site

Abstract

A study funded by the National Institute of Child Health and Human Development is designed to determine which of the 2 drugs commonly prescribed to treat status epilepticus in children is safer and more effective. Status epilepticus affects up to 8 in 1000 children before they reach age 15 years and is fatal in 4% of cases. The study will be conducted at 11 hospitals in which children presenting to the emergency departments with status epilepticus will be randomly assigned to either diazepam or lorazepam (http://www.nichd.nih.gov/news/releases/study_pediatric_seizure_QA_052207.cfm). Diazepam is approved for use in adults and children while lorazepam is approved for adults but is being used off label for children. As status epilepticus must be treated within 5 minutes of presentation in the emergency department to minimize the risk of brain injury or death, consent from a parent to enroll a child in the study will be sought after treatment. If a parent declines consent, the child will then be withdrawn from any further aspects of the study. Independent boards or research review committees at each hospital will oversee the study to ensure all procedures comply with ethics and safety standards.

Journal

JAMAAmerican Medical Association

Published: Jun 27, 2007

Keywords: seizures,pediatrics

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