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PECTIN AND GALACTURONIC ACID AND THE INTESTINAL PATHOGENS

PECTIN AND GALACTURONIC ACID AND THE INTESTINAL PATHOGENS Previous work has strongly indicated that apple and pectin exert their favorable effect on diarrhea by way of their local action in the intestine.1 The cellulose and lignin contained in apples must act as an absorbing colloid or mechanically, since they are not appreciably decomposed. The pectin, which is decomposed only in the colon,2 could act similarly in the small intestine, but not in the colon, unless, as in the fasting dog, considerable pectin is not decomposed.3 The local effect of pectin in the colon, therefore, is due to the action either of the intact molecule or of its decomposition products on pathogenic flora or their toxic or irritating products. The chief products found to be formed in the decomposition of pectin were formic and acetic acids; either the quantity of galacturonic acid produced (pectin is a galacturonic acid complex) is small or it is decomposed as http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American journal of diseases of children American Medical Association

PECTIN AND GALACTURONIC ACID AND THE INTESTINAL PATHOGENS

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Publisher
American Medical Association
Copyright
Copyright © 1942 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
0096-8994
eISSN
1538-3628
DOI
10.1001/archpedi.1942.02010050003001
Publisher site
See Article on Publisher Site

Abstract

Previous work has strongly indicated that apple and pectin exert their favorable effect on diarrhea by way of their local action in the intestine.1 The cellulose and lignin contained in apples must act as an absorbing colloid or mechanically, since they are not appreciably decomposed. The pectin, which is decomposed only in the colon,2 could act similarly in the small intestine, but not in the colon, unless, as in the fasting dog, considerable pectin is not decomposed.3 The local effect of pectin in the colon, therefore, is due to the action either of the intact molecule or of its decomposition products on pathogenic flora or their toxic or irritating products. The chief products found to be formed in the decomposition of pectin were formic and acetic acids; either the quantity of galacturonic acid produced (pectin is a galacturonic acid complex) is small or it is decomposed as

Journal

American journal of diseases of childrenAmerican Medical Association

Published: May 1, 1942

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