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Peak Expiratory Flow Rates in Chronic Asthma: A Gauge of Progression and Improvement

Peak Expiratory Flow Rates in Chronic Asthma: A Gauge of Progression and Improvement Abstract Because there is doubt over the usefulness of the peak expiratory flow meter in assessing the course of chronic asthma, 55 children aged 6 to 18 years were studied over a period of 12 months. All children, who were receiving cromolyn sodium prophylaxis, were tested at monthly intervals with the peak expiratory flow rate (PEFR) meter and at three-month intervals by conventional spirometry. The patients were separated into three groups according to their monthly PEFR results: (1) values always within normal limits; (2) values fluctuating between normal and abnormal ranges; and (3) values consistently subnormal. A "drop-off" of at least 15% in PEFR was observed with 25 of the 55 children when five successive expirations were measured. The PEFR, the forced expiratory volume in the first second, and the maximum voluntary ventilation correlated well (P =.001) in all cases. Pulmonary function values in 16 patients (29%) failed to show the expected return to normal during the one-year period. References 1. National Center for Health Statistics: Chronic conditions and limitations of activity and mobility , in Vital and Health Statistics , publication 100, series 10, no. 61, Public Health Service, Jan 1971. 2. Wright BM, McKerrow CB: Maximum expiratory flow rate as a measure of ventilatory capacity . Br Med J 5159:1041-1046, 1959.Crossref 3. Kendig EL Jr (ed): Pulmonary Disorders . Philadelphia, WB Saunders Co, 1972, vol 1, p 20. 4. Bates DV, Macklem PT, Christie RV: Respiratory Function in Disease . Philadelphia, WB Saunders Co, 1971, pp 22-23. 5. Hyde JS, Floro LD, Vithayasai V: Chronic and high risk asthma in children . Am J Dis Child 123:541-546, 1972. 6. Vance JW: Bellows-type spirometer for measuring the forced expirogram . Chest 43:57-61, 1963.Crossref 7. Weng TR, Levinson H: Standards of pulmonary function in children . Am Rev Resp Dis 99:879-894, 1969. 8. Bjure I: Spirometric studies in normal subjects: IV. Ventilatory capacities in healthy children 7 to 17 years of age . Acta Paediatr 52:232-240, 1963.Crossref 9. Polgar CG, Promadhat V: Pulmonary Function Testing in Children: Techniques and Standards . Philadelphia, WB Saunders Co, 1971, pp 87-121. 10. Murray AB, Cooke CD: Measurements of peak expiratory flow rate in 220 normal children from 4.5 to 18.5 years of age . J Pediatr 62:186-188, 1963.Crossref 11. Cade JF, Pain MCF: Role of bronchial reactivity in etiology of asthma . Lancet 2:186-189, 1971.Crossref 12. Cox JS, et al: Disodium cromoglycate , in Harper NJ, Simmonds AB: Advances in Drug Research . New York, Academic Press, 1970, pp 115-196. 13. Astin TW: The effect of disodium cromoglycate on airways resistance in patients with extrinsic asthma . Br J Clin Prac 25:459-462, 1971. 14. Chai HP, et al: Therapeutic and investigational evaluation of asthmatic children . J Allergy 41:23-36, 1969.Crossref 15. Connolly N, Godfrey S: Assessment of the child with asthma . J Asthma Res 8:31-36, 1970.Crossref 16. Toogood JH, et al: A double-blind study of disodium cromoglycate for prophylaxis of bronchial asthma . Am Rev Resp Dis 104:323-330, 1971. 17. Patel KR, Kerr JQ, Wade IM: The effect of disodium cromoglycate on pulmonary function in extrinsic bronchial asthma over 12 months . Clin Allergy 1:199-207, 1971.Crossref 18. Robertson DG, Epstein SW, Warrel DA: Trial of disodium cromoglycate in bronchial asthma . Br Med J 1:552-554, 1969.Crossref 19. Collins-Williams C, et al: Treatment of bronchial asthma with disodium cromoglycate (Intal) in children . Ann Allergy 29:613-620, 1971. 20. Glass RD: Experience with disodium cromoglycate in the treatment of asthmatic children . Med J Aust 1:1382-1387, 1971. 21. Chan-Yeung M, Morton J, Graybowski S: A double-blind trial of disodium cromoglycate (Intal) in the treatment of bronchial asthma . Canad Med Assoc J 105:827-831, 1971. 22. Sly RM: Evaluation of disodium cromoglycate in asthmatic children . Ann Allergy 28:299-306, 1970. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Diseases of Children American Medical Association

Peak Expiratory Flow Rates in Chronic Asthma: A Gauge of Progression and Improvement

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Publisher
American Medical Association
Copyright
Copyright © 1973 American Medical Association. All Rights Reserved.
ISSN
0002-922X
DOI
10.1001/archpedi.1973.04160030021004
Publisher site
See Article on Publisher Site

Abstract

Abstract Because there is doubt over the usefulness of the peak expiratory flow meter in assessing the course of chronic asthma, 55 children aged 6 to 18 years were studied over a period of 12 months. All children, who were receiving cromolyn sodium prophylaxis, were tested at monthly intervals with the peak expiratory flow rate (PEFR) meter and at three-month intervals by conventional spirometry. The patients were separated into three groups according to their monthly PEFR results: (1) values always within normal limits; (2) values fluctuating between normal and abnormal ranges; and (3) values consistently subnormal. A "drop-off" of at least 15% in PEFR was observed with 25 of the 55 children when five successive expirations were measured. The PEFR, the forced expiratory volume in the first second, and the maximum voluntary ventilation correlated well (P =.001) in all cases. Pulmonary function values in 16 patients (29%) failed to show the expected return to normal during the one-year period. References 1. National Center for Health Statistics: Chronic conditions and limitations of activity and mobility , in Vital and Health Statistics , publication 100, series 10, no. 61, Public Health Service, Jan 1971. 2. Wright BM, McKerrow CB: Maximum expiratory flow rate as a measure of ventilatory capacity . Br Med J 5159:1041-1046, 1959.Crossref 3. Kendig EL Jr (ed): Pulmonary Disorders . Philadelphia, WB Saunders Co, 1972, vol 1, p 20. 4. Bates DV, Macklem PT, Christie RV: Respiratory Function in Disease . Philadelphia, WB Saunders Co, 1971, pp 22-23. 5. Hyde JS, Floro LD, Vithayasai V: Chronic and high risk asthma in children . Am J Dis Child 123:541-546, 1972. 6. Vance JW: Bellows-type spirometer for measuring the forced expirogram . Chest 43:57-61, 1963.Crossref 7. Weng TR, Levinson H: Standards of pulmonary function in children . Am Rev Resp Dis 99:879-894, 1969. 8. Bjure I: Spirometric studies in normal subjects: IV. Ventilatory capacities in healthy children 7 to 17 years of age . Acta Paediatr 52:232-240, 1963.Crossref 9. Polgar CG, Promadhat V: Pulmonary Function Testing in Children: Techniques and Standards . Philadelphia, WB Saunders Co, 1971, pp 87-121. 10. Murray AB, Cooke CD: Measurements of peak expiratory flow rate in 220 normal children from 4.5 to 18.5 years of age . J Pediatr 62:186-188, 1963.Crossref 11. Cade JF, Pain MCF: Role of bronchial reactivity in etiology of asthma . Lancet 2:186-189, 1971.Crossref 12. Cox JS, et al: Disodium cromoglycate , in Harper NJ, Simmonds AB: Advances in Drug Research . New York, Academic Press, 1970, pp 115-196. 13. Astin TW: The effect of disodium cromoglycate on airways resistance in patients with extrinsic asthma . Br J Clin Prac 25:459-462, 1971. 14. Chai HP, et al: Therapeutic and investigational evaluation of asthmatic children . J Allergy 41:23-36, 1969.Crossref 15. Connolly N, Godfrey S: Assessment of the child with asthma . J Asthma Res 8:31-36, 1970.Crossref 16. Toogood JH, et al: A double-blind study of disodium cromoglycate for prophylaxis of bronchial asthma . Am Rev Resp Dis 104:323-330, 1971. 17. Patel KR, Kerr JQ, Wade IM: The effect of disodium cromoglycate on pulmonary function in extrinsic bronchial asthma over 12 months . Clin Allergy 1:199-207, 1971.Crossref 18. Robertson DG, Epstein SW, Warrel DA: Trial of disodium cromoglycate in bronchial asthma . Br Med J 1:552-554, 1969.Crossref 19. Collins-Williams C, et al: Treatment of bronchial asthma with disodium cromoglycate (Intal) in children . Ann Allergy 29:613-620, 1971. 20. Glass RD: Experience with disodium cromoglycate in the treatment of asthmatic children . Med J Aust 1:1382-1387, 1971. 21. Chan-Yeung M, Morton J, Graybowski S: A double-blind trial of disodium cromoglycate (Intal) in the treatment of bronchial asthma . Canad Med Assoc J 105:827-831, 1971. 22. Sly RM: Evaluation of disodium cromoglycate in asthmatic children . Ann Allergy 28:299-306, 1970.

Journal

American Journal of Diseases of ChildrenAmerican Medical Association

Published: Mar 1, 1973

References