Abstract LEUKOPLAKIA is the most commonly observed oral keratotic lesion. There are essentially two main types that can be differentiated microscopically. The majority of cases are characterized histologically by varying degrees of hyperkeratosis, parakeratosis, or a combination of both types of keratinization.1,2 This form of leukoplakia is referred to as the simple hyperkeratotic variety or benign leukoplakia.3 In about 10% of the cases of oral leukoplakia, there is the additional histologic feature of dysplasia or atypia.4,5 This variety of leukoplakia is referred to as the dysplastic, premalignant, or malignant form, and is comparable to the so called precancerous dermatoses, such as Bowen's disease. The benign form of oral leukoplakia represents a simple hyperkeratotic response to irritation. The dysplastic form of oral leukoplakia represents a premalignant lesion and may be regarded as a carcinoma in situ. The essential alteration from normal to malignant has already occurred and these lesions References 1. McCarthy, F.P.: Etiology, Pathology, and Treatment of Leukoplakia Buccalis With Report of 316 Cases , Arch Derm Syph 34:612, 1936.Crossref 2. Renstrup, G.: Leukoplakia of the Oral Cavity , Acta Odont Scand 16:99, 1958.Crossref 3. McCarthy, P.L., and Shklar, G.: Diseases of the Oral Mucosa , New York: McGraw-Hill Book Co., 1964, p 104. 4. Shafer, W.G., and Waldron, C.A.: A Clinical and Histopathologic Study of Leukoplakia , Surg Gynec Obstet 112:411, 1961. 5. Shklar, G.: The Precancerous Oral Lesion , Oral Surg 20:58-70, 1965.Crossref 6. Ayoub, P., and Shklar, G.: A Modification of the Mallory Connective Tissue Stain as a Stain for Keratin , Oral Surg 16:580, 1963.Crossref 7. Glenner, G.G., and Lillie, R.D.: Observations of the Diazotization Coupling Reaction for the Histochemical Demonstration of Tyrosine: Metal Chelation and Formazon Variants , J Histochem Cytochem 7:416, 1959.Crossref 8. Barnett, R.J., and Seligman, A.M.: Histochemical Demonstration of Sulfhydryl and Disulfide Groups of Protein , J Nat Cancer Inst 14:769, 1954. 9. Turesky, S.; Glickman, I.; and Provost, J.: A Histochemical Study of the Keratotic Process in Oral Lesions Diagnosed Clinically as Leukoplakia , Oral Surg 14:442-453, 1961.Crossref 10. Shklar, G.: Oral Leukoplakia: Studies in Enzyme Histochemistry , J Invest Derm 48:153-158, 1967. 11. Baratieri, A., and Preda, G.E.: Aspetti istochimici di leucoplachie orali , Arch De Vecchi Anat Pat 44:489-526, 1964. 12. Hashimoto, K., et al: Electron Microscopic Studies of Oral Benign Leukoplakia , Oral Surg , to be published.
Archives of Otolaryngology – American Medical Association
Published: Apr 1, 1968
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