ORIGINAL CONTRIBUTION Patterns and Trends in Antipsychotic Prescribing for Parkinson Disease Psychosis Daniel Weintraub, MD; Peijun Chen, MD, PhD, MPH; Rosalinda V. Ignacio, MS; Eugenia Mamikonyan, MS; Helen C. Kales, MD Background: Antipsychotic (AP) use is common in Par- Main Outcome Measure: Antipsychotic prescribing, kinson disease (PD), but APs can worsen parkinsonism, including overall, class, and specific medications. evidence for efficacy is limited, and use in patients with dementia increases mortality. Results: In FY2008, 50% of patients with PD having a di- agnosis of psychosis were prescribed an AP. Among treated Objective: To examine the frequency and characteris- patients, the atypical AP quetiapine was most frequently tics, including changes over time, of AP use in a large prescribed (66%), but approximately 30% received high- cohort of patients with PD. potency APs. Clozapine was rarely prescribed (2%). In multivariate models, diagnoses of PD and dementia were Design: Using Veterans Affairs data from fiscal year associated with AP use. Comparing FY2008 with FY2002, (FY) 2008, rates and predictors of AP prescribing were AP use in PD was unchanged, with decreases in risperi- determined for patients with PD and psychosis stratified done and olanzapine use offset by an increase in quetiap- by
JAMA Neurology – American Medical Association
Published: Jul 1, 2011
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