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Patient-Reported Outcomes Following Treatment for Localized Prostate Cancer

Patient-Reported Outcomes Following Treatment for Localized Prostate Cancer Opinion EDITORIAL Patient-Reported Outcomes Following Treatment for Localized Prostate Cancer Helping Decision Making for Patients and Their Physicians Freddie C. Hamdy, MD, FMedSci; Jenny L. Donovan, PhD, FMedSci When treatments are known to be successful with good on- therapy, and proton beam and focal therapy, each with advo- cological outcomes for specific cancers, most patients will be cates claiming high levels of effectiveness, reduced adverse- prepared to accept the proposed therapy and its consequences effect profiles, yet lacking comparative evidence. on quality of life. But when Previous randomized clinical trials of treatment included multiple, equally effective limited analyses of quality-of-life outcomes. The Prostate treatments are available and Intervention vs Observation Trial (PIVOT) used single items Author Audio Interview uncertainty about their ben- to assess urinary-, sexual-, and bowel-related adverse effects, efits prevails with a substan- and the Scandinavian Prostate Cancer 4 (SPCG-4) Trial com- Related articles pages 1126 and tial risk of overtreatment, the paring radical prostatectomy vs watchful waiting in the pre- balance of risks between ben- PSA era used a study-specific questionnaire. Nevertheless, both efit and harm from adverse effects can dominate decision studies showed greater adverse effects on continence and sexual making. Such is the case http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA American Medical Association

Patient-Reported Outcomes Following Treatment for Localized Prostate Cancer

JAMA , Volume 317 (11) – Mar 21, 2017

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Publisher
American Medical Association
Copyright
Copyright 2017 American Medical Association. All Rights Reserved.
ISSN
0098-7484
eISSN
1538-3598
DOI
10.1001/jama.2017.1703
pmid
28324073
Publisher site
See Article on Publisher Site

Abstract

Opinion EDITORIAL Patient-Reported Outcomes Following Treatment for Localized Prostate Cancer Helping Decision Making for Patients and Their Physicians Freddie C. Hamdy, MD, FMedSci; Jenny L. Donovan, PhD, FMedSci When treatments are known to be successful with good on- therapy, and proton beam and focal therapy, each with advo- cological outcomes for specific cancers, most patients will be cates claiming high levels of effectiveness, reduced adverse- prepared to accept the proposed therapy and its consequences effect profiles, yet lacking comparative evidence. on quality of life. But when Previous randomized clinical trials of treatment included multiple, equally effective limited analyses of quality-of-life outcomes. The Prostate treatments are available and Intervention vs Observation Trial (PIVOT) used single items Author Audio Interview uncertainty about their ben- to assess urinary-, sexual-, and bowel-related adverse effects, efits prevails with a substan- and the Scandinavian Prostate Cancer 4 (SPCG-4) Trial com- Related articles pages 1126 and tial risk of overtreatment, the paring radical prostatectomy vs watchful waiting in the pre- balance of risks between ben- PSA era used a study-specific questionnaire. Nevertheless, both efit and harm from adverse effects can dominate decision studies showed greater adverse effects on continence and sexual making. Such is the case

Journal

JAMAAmerican Medical Association

Published: Mar 21, 2017

References