Abstract The daily application of human sebum for two weeks to the external canal of the rabbit ear induced the following histologic changes: (1) hyperplasia of the epidermis and epithelial linings of the sebaceous ducts and follicles, (2) distention of the ducts and follicles with keratinized squamae to form horny impactions or comedones, and (3) variable inflammatory changes exemplified by follicular pustules and infiltration of the dermis by mononuclears and polymorphonuclear leukocytes. The comedogenic potency of sebum is considerably less than that of a chemical acneigen such as Halowax 1014. The comedones were smaller and never attained maturity. References 1. Kligman, A.M., and Katz, A.G.: The Pathogenesis of Acne Vulgaris: I. Comedo-Inducing Properties of Sebum , Arch Derm 98:53-57 ( (July) ) 1968.Crossref 2. Lorincz, A.L.; Krizek, H.; and Brown, S.: Follicular Hyperkeratinization Induced in the Rabbit Ear by Human Skin Surface Lipids , read before the International Congress of Dermatology, Munich, Germany, 1967 . 3. Hambrick, G.W., Jr., and Blank, H.: A Microanatomical Study of the Response of the Pilo-Sebaceous Apparatus of the Rabbit's Ear Canal , J Invest Derm 26:185, 1956. 4. Marples, M.J.: The Ecology of the Human Skin , Springfield, Ill, Charles C Thomas, Publisher, 1965. p 412. 5. Strauss, J.S., and Kligman, A.M.: The Pathologic Dynamics of Acne Vulgaris , Arch Derm 82:779, 1960.Crossref 6. Jones, E.L., and Krizek, H.: A Technic for Testing Acneigenic Potency in Rabbits Applied to the Potent Acnegen 2,3,7,8-tetrachlorodibenzo-p-dioxin , J Invest Derm 39:511, 1962.Crossref 7. Hambrick, G.W., Jr.: The Effect of Substituted Naphthalenes on the Pilo-Sebaceous Apparatus of Rabbit and Man , J Invest Derm 28:89, 1957.
Archives of Dermatology – American Medical Association
Published: Jul 1, 1968