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Partial DiGeorge Syndrome or Branchial Dysembryogenesis?

Partial DiGeorge Syndrome or Branchial Dysembryogenesis? Abstract Sir.—Pabst et al recently reported in the Journal two cases of partial DiGeorge syndrome with substantial cell-mediated immunity (130:316, 1976). Their second case exhibited normal, although scanty, thymus tissue and normal lymph node tissue at autopsy. Associated anomalies from branchial levels other than the third and fourth levels were present in both cases described. Lip and external ear anomalies evolve from branchial level I and pulmonary artery anomalies evolve from branchial level VI.1 Since the DiGeorge syndrome is also called the "III and IV branchial pouch syndrome,"2.3 both terms are therefore misleading. In 1972,4 we reported on four patients with congenital hypoparathyroidism and associated anomalies of other branchial arches and pouches. One was an infant with a classical "DiGeorge syndrome" who died soon after birth. The most characteristic features in the other three patients, in addition to congenital hypoparathyroidism, were (1) a peculiar hypernasal speech resulting References 1. Allan FD: Essentials of Embryology , ed 2. New York, Oxford University Press, 1969, pp 95-96, 133-144. 2. Harrison's Principles of Internal Medicine , ed 7. New York, McGraw-Hill Book Co, 1974. 3. Lobell DH: DiGeorge's syndrome . Arch Pathol 87:353-354, 1969. 4. Miller MJ, Frame B, Pozanski AK, et al: Branchial anomalies in idiopathic hypoparathyroidism: Branchial dysembryogenesis . Henry Ford Hosp Med J 20:3-14, 1972. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Diseases of Children American Medical Association

Partial DiGeorge Syndrome or Branchial Dysembryogenesis?

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Publisher
American Medical Association
Copyright
Copyright © 1976 American Medical Association. All Rights Reserved.
ISSN
0002-922X
DOI
10.1001/archpedi.1976.02120130082023
Publisher site
See Article on Publisher Site

Abstract

Abstract Sir.—Pabst et al recently reported in the Journal two cases of partial DiGeorge syndrome with substantial cell-mediated immunity (130:316, 1976). Their second case exhibited normal, although scanty, thymus tissue and normal lymph node tissue at autopsy. Associated anomalies from branchial levels other than the third and fourth levels were present in both cases described. Lip and external ear anomalies evolve from branchial level I and pulmonary artery anomalies evolve from branchial level VI.1 Since the DiGeorge syndrome is also called the "III and IV branchial pouch syndrome,"2.3 both terms are therefore misleading. In 1972,4 we reported on four patients with congenital hypoparathyroidism and associated anomalies of other branchial arches and pouches. One was an infant with a classical "DiGeorge syndrome" who died soon after birth. The most characteristic features in the other three patients, in addition to congenital hypoparathyroidism, were (1) a peculiar hypernasal speech resulting References 1. Allan FD: Essentials of Embryology , ed 2. New York, Oxford University Press, 1969, pp 95-96, 133-144. 2. Harrison's Principles of Internal Medicine , ed 7. New York, McGraw-Hill Book Co, 1974. 3. Lobell DH: DiGeorge's syndrome . Arch Pathol 87:353-354, 1969. 4. Miller MJ, Frame B, Pozanski AK, et al: Branchial anomalies in idiopathic hypoparathyroidism: Branchial dysembryogenesis . Henry Ford Hosp Med J 20:3-14, 1972.

Journal

American Journal of Diseases of ChildrenAmerican Medical Association

Published: Dec 1, 1976

References

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