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Partial Antibiotic Therapy in Haemophilus influenzae Meningitis: Its Effect on Cerebrospinal Fluid Abnormalities

Partial Antibiotic Therapy in Haemophilus influenzae Meningitis: Its Effect on Cerebrospinal... Abstract To examine the influence of partial antibiotic therapy on laboratory findings in Haemophilus influenzae meningitis, 272 untreated cases and 202 partially treated, culture-positive cases from 1953 through 1971 were reviewed. There was no significant difference between the two groups with respect to several cerebrospinal fluid (CSF) values. Both the untreated and partially treated groups had a similar proportion of cases with negative Gram stain and CSF glucose level over 40 mg/100 ml or a predominance of CSF mononuclear cells. Eight patients had received ampicillin sodium, chloramphenicol, or tetracycline for two days or more. The CSF findings of these patients resembled those of the untreated group. The data support the conclusion that antibiotics In the usual outpatient dosages seldom interfere with the diagnosis of H influenzae meningitis. References 1. Nelson WE, Vaughan VC III, McKay RJ (eds): Textbook of Pediatrics , ed 9. Philadelphia, WB Saunders Co, 1969, p 571. 2. Barnett HL (ed): Pediatrics , ed 15. New York, Appleton-Century-Crofts Inc, 1972, p 672. 3. Mathies WW Jr, Wehrle PF: Management of bacterial meningitis in children . Pediatr Clin North Am 15:185-195, 1968. 4. Wintrobe MM, Thorn GW, Adams RD, et al (eds): Harrison's Princples of Internal Medicine , ed 6. New York, McGraw-Hill Book Co Inc, 1970, vol 2, p 1794. 5. Quaade F, Kristensen KP: Purulent meningitis: A review of 658 cases . Acta Med Scand 171:543-550, 1962.Crossref 6. Harter DH: Preliminary antibiotic therapy in bacterial meningitis . Arch Neurol 9:343-347, 1963.Crossref 7. Dalton HP, Allison MJ Jr: Modification of laboratory results by partial treatment of bacterial meningitis . Am J Clin Pathol 49:410-413, 1968. 8. Winkelstein JA: The influence of partial treatment with penicillin on the diagnosis of bacterial meningitis . J Pediatr 77:619-624, 1970.Crossref 9. Jarvis CW, Saxena KM: Does prior antibiotic treatment hamper the diagnosis of acute bacterial meningitis? An analysis of a series of 135 childhood cases . Clin Pediatr 11:201-204, 1972.Crossref 10. Converse GM, Gwaltney JM Jr, Strassburg DA, et al: Alteration of cerebrospinal fluid findings by partial treatment of bacterial meningitis . J Pediatr 83:220-225, 1973.Crossref 11. Wilfert CM: Mumps meningoencephalitis with low cerebrospinal fluid glucose, prolonged pleocytosis, and elevation of proteins . N Engl J Med 280:855-859, 1969.Crossref 12. Lepow ML, Coyne M, Thompson LB, et al: A clinical epidemiologic and laboratory investigation of aseptic meningitis during the four year period, 1955-1958: II. The clinical disease and its sequelae . N Engl J Med 266:1188-1193, 1962.Crossref 13. Edwards EA, Muehl PM, Peckinpaugh RO: Diagnosis of bacterial meningitis by counter immunoelectrophoresis . J Lab Clin Med 80:449-454, 1972. 14. Rojas-Corona RR, Skarnes R, Tamakuma S, et al: The Limulus coagulation test for endotoxin: A comparison with other assay methods . Proc Soc Exp Biol Med 132:599-601, 1969.Crossref 15. Feigin RD, Shackelford PG: Value of repeat lumbar puncture in the differential diagnosis of meningitis . N Engl J Med 289:571-573, 1973.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Diseases of Children American Medical Association

Partial Antibiotic Therapy in Haemophilus influenzae Meningitis: Its Effect on Cerebrospinal Fluid Abnormalities

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References (16)

Publisher
American Medical Association
Copyright
Copyright © 1975 American Medical Association. All Rights Reserved.
ISSN
0002-922X
DOI
10.1001/archpedi.1975.02120440028007
Publisher site
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Abstract

Abstract To examine the influence of partial antibiotic therapy on laboratory findings in Haemophilus influenzae meningitis, 272 untreated cases and 202 partially treated, culture-positive cases from 1953 through 1971 were reviewed. There was no significant difference between the two groups with respect to several cerebrospinal fluid (CSF) values. Both the untreated and partially treated groups had a similar proportion of cases with negative Gram stain and CSF glucose level over 40 mg/100 ml or a predominance of CSF mononuclear cells. Eight patients had received ampicillin sodium, chloramphenicol, or tetracycline for two days or more. The CSF findings of these patients resembled those of the untreated group. The data support the conclusion that antibiotics In the usual outpatient dosages seldom interfere with the diagnosis of H influenzae meningitis. References 1. Nelson WE, Vaughan VC III, McKay RJ (eds): Textbook of Pediatrics , ed 9. Philadelphia, WB Saunders Co, 1969, p 571. 2. Barnett HL (ed): Pediatrics , ed 15. New York, Appleton-Century-Crofts Inc, 1972, p 672. 3. Mathies WW Jr, Wehrle PF: Management of bacterial meningitis in children . Pediatr Clin North Am 15:185-195, 1968. 4. Wintrobe MM, Thorn GW, Adams RD, et al (eds): Harrison's Princples of Internal Medicine , ed 6. New York, McGraw-Hill Book Co Inc, 1970, vol 2, p 1794. 5. Quaade F, Kristensen KP: Purulent meningitis: A review of 658 cases . Acta Med Scand 171:543-550, 1962.Crossref 6. Harter DH: Preliminary antibiotic therapy in bacterial meningitis . Arch Neurol 9:343-347, 1963.Crossref 7. Dalton HP, Allison MJ Jr: Modification of laboratory results by partial treatment of bacterial meningitis . Am J Clin Pathol 49:410-413, 1968. 8. Winkelstein JA: The influence of partial treatment with penicillin on the diagnosis of bacterial meningitis . J Pediatr 77:619-624, 1970.Crossref 9. Jarvis CW, Saxena KM: Does prior antibiotic treatment hamper the diagnosis of acute bacterial meningitis? An analysis of a series of 135 childhood cases . Clin Pediatr 11:201-204, 1972.Crossref 10. Converse GM, Gwaltney JM Jr, Strassburg DA, et al: Alteration of cerebrospinal fluid findings by partial treatment of bacterial meningitis . J Pediatr 83:220-225, 1973.Crossref 11. Wilfert CM: Mumps meningoencephalitis with low cerebrospinal fluid glucose, prolonged pleocytosis, and elevation of proteins . N Engl J Med 280:855-859, 1969.Crossref 12. Lepow ML, Coyne M, Thompson LB, et al: A clinical epidemiologic and laboratory investigation of aseptic meningitis during the four year period, 1955-1958: II. The clinical disease and its sequelae . N Engl J Med 266:1188-1193, 1962.Crossref 13. Edwards EA, Muehl PM, Peckinpaugh RO: Diagnosis of bacterial meningitis by counter immunoelectrophoresis . J Lab Clin Med 80:449-454, 1972. 14. Rojas-Corona RR, Skarnes R, Tamakuma S, et al: The Limulus coagulation test for endotoxin: A comparison with other assay methods . Proc Soc Exp Biol Med 132:599-601, 1969.Crossref 15. Feigin RD, Shackelford PG: Value of repeat lumbar puncture in the differential diagnosis of meningitis . N Engl J Med 289:571-573, 1973.Crossref

Journal

American Journal of Diseases of Children – American Medical Association

Published: Jul 1, 1975

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