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Paroxysmal Nocturnal Hemoglobinuria

Paroxysmal Nocturnal Hemoglobinuria Abstract To the Editor. —We read with interest the article by Engel et al that appeared in a recent issue of the Archives (1982;142:287-288) and the editorial by Dr Crosby (233-235). These and other observations make it clear that bone marrow iron may not always reflect body iron stores in some patients' conditions. Many of these patients' conditions are characterized by sequestered deposits of iron that are unavailable for hematopoiesis, as in paroxysmal nocturnal hemoglobinuria (PNH)1 and idiopathic pulmonary hemosiderosis.2 Whether the serum ferritin levels would be reflective of the sequestered stores of iron has not been investigated. Our recent experience with a patient with PNH and iron deficiency anemia prompted this letter. Report of a Case. —A 25-year-old man was admitted to Cook County Hospital, Chicago, on Feb 23, 1981, for evaluation of anemia. A diagnosis of aplastic anemia had been made ten years earlier at another hospital, References 1. Dacie JV: The Hemolytic Anemias: Congenital and Acquired , ed 2. New York, Grune & Stratton Inc, 1967, pt 4, pp 1162-1164. 2. Fairbanks VF, Beutler E: Congenital atransferrinemia and idiopathic pulmonary hemosiderosis , in Williams WJ, Beutler E, Erslev AJ, et al (eds): Hematology . New York, McGraw-Hill Book Co, 1977, p 388. 3. Bunn HR, Jandl JH: The renal handling of hemoglobin: II. Catabolism. J Exp Med 1969; 129:925-934.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Internal Medicine American Medical Association

Paroxysmal Nocturnal Hemoglobinuria

Paroxysmal Nocturnal Hemoglobinuria

Abstract

Abstract To the Editor. —We read with interest the article by Engel et al that appeared in a recent issue of the Archives (1982;142:287-288) and the editorial by Dr Crosby (233-235). These and other observations make it clear that bone marrow iron may not always reflect body iron stores in some patients' conditions. Many of these patients' conditions are characterized by sequestered deposits of iron that are unavailable for hematopoiesis, as in paroxysmal nocturnal...
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Publisher
American Medical Association
Copyright
Copyright © 1983 American Medical Association. All Rights Reserved.
ISSN
0003-9926
eISSN
1538-3679
DOI
10.1001/archinte.1983.00350010195046
Publisher site
See Article on Publisher Site

Abstract

Abstract To the Editor. —We read with interest the article by Engel et al that appeared in a recent issue of the Archives (1982;142:287-288) and the editorial by Dr Crosby (233-235). These and other observations make it clear that bone marrow iron may not always reflect body iron stores in some patients' conditions. Many of these patients' conditions are characterized by sequestered deposits of iron that are unavailable for hematopoiesis, as in paroxysmal nocturnal hemoglobinuria (PNH)1 and idiopathic pulmonary hemosiderosis.2 Whether the serum ferritin levels would be reflective of the sequestered stores of iron has not been investigated. Our recent experience with a patient with PNH and iron deficiency anemia prompted this letter. Report of a Case. —A 25-year-old man was admitted to Cook County Hospital, Chicago, on Feb 23, 1981, for evaluation of anemia. A diagnosis of aplastic anemia had been made ten years earlier at another hospital, References 1. Dacie JV: The Hemolytic Anemias: Congenital and Acquired , ed 2. New York, Grune & Stratton Inc, 1967, pt 4, pp 1162-1164. 2. Fairbanks VF, Beutler E: Congenital atransferrinemia and idiopathic pulmonary hemosiderosis , in Williams WJ, Beutler E, Erslev AJ, et al (eds): Hematology . New York, McGraw-Hill Book Co, 1977, p 388. 3. Bunn HR, Jandl JH: The renal handling of hemoglobin: II. Catabolism. J Exp Med 1969; 129:925-934.Crossref

Journal

Archives of Internal MedicineAmerican Medical Association

Published: Jan 1, 1983

References