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PAROXYSMAL COLD HEMOGLOBINURIAS

PAROXYSMAL COLD HEMOGLOBINURIAS Abstract DRESSLER1 is credited with having first reported observations on a case of "paroxysmal cold hemoglobinuria," a symptom complex now known to have two separate and distinct etiologic bases. The first and more generally recognized type is syphilitic paroxysmal cold hemoglobinuria, a disease seen in a small percentage of persons with syphilis and caused by a cold-warm hemolysin unique to persons with syphilis with this disease. The second and nonsyphilitic type is cold hemagglutination paroxysmal hemoglobinuria, a disease accompanied with unusually high titers of cold hemagglutinins and first reported by Salén2 in 1935 when he recorded observations on pronounced cold agglutination of the red blood cells of a nonsyphilitic patient with paroxysmal cold hemoglobinuria. This paper will be concerned primarily with the syphilitic type of paroxysmal cold hemoglobinuria. Care was taken to avoid the error of including reports of cold hemagglutination paroxysmal hemoglobinuria in this review of cases of References 1. Dressler, cited by Macalister3 2. Mackenzie.4 3. Salén, E. B.: Thermostabiles, nicht komplexes (Auto-) Hämolysin bei transitorischer Kältehämoglobinurie , Acta med. Scandinav. 86:570, 1935.Crossref 4. Macalister, G. H. K.: The Pathology of Paroxysmal Hemoglobinuria: A Critical Review , Quart. J. Med. 2:368, 1908-1909. 5. Mackenzie, G. M.: Paroxysmal Hemoglobinuria: A Review , Medicine 8:159 ( (May) ) 1929.Crossref 6. Jones, B. B., and Jones, C. M.: Paroxysmal Hemoglobinuria , in Nelson Loose-Leaf Living Medicine , New York, Thos. Nelson & Sons, 1920-1929, vol. 4, p. 173A. 7. Howard, C. P.; Mills, F. S., and Townsend, S. R.: Paroxysmal Hemoglobinuria with Report of Case , Am. J. M. Sc. 196:772 ( (Dec.) ) 1938.Crossref 8. Donath, J., and Landsteiner, K.: Ueber paroxysmale Hämoglobinurie , München. med. Wchnschr. 51:1509, 1904. 9. Eason, J.: The Pathology of Paroxysmal Hæmoglobinuria,ia , J. Path. & Bact. 11:167, 1906. 10. Widal, F.; Abrami, P., and Brissaud, E.: Recherches sur l'hémoglobinurie paroxystique à frigore , Compt. rend. Soc. de biol. 65:429, 1913. 11. Donath, J., and Landsteiner, K.: Ueber Kältehämoglobinurie , Ergebn. d. Hyg. , Bakt. 7:184, 1925. 12. Ernstene, A. C., and Gardner, W. J.: The Effect of Splanchnic Nerve Resection and Sympathetic Ganglionectomy in a Case of Paroxysmal Hemoglobinuria , J. Clin. Investigation 14:799 ( (Nov.) ) 1935. 13. Roch, M. M., and Liengme, A.: Hémoglobinurie paroxystique et angine éryhthémateuse "a frigore," Bull. et mém. Soc. méd. d. hôp. de Paris 46:1737, 1922. 14. Lopes, D. M.: Hemoglobinuria paroxistica "a frigore," Brasil-med. 48:486 ( (Dec. 16-30) ) 1944. 15. York, W., and Macfie, J. W. S.: Mechanism of Autolysis in Paroxysmal Hemoglobinuria , Brit. J. Exper. Path. 2:115 ( (June) ) 1921. 16. Burmeister, J.: Ueber paroxysmale Hämoglubinurie and Syphilis , Ztschr. f. klin. Med. 92:19, 1921. 17. Smith, R. P.: The Relationship of the Autolysin and the Wassermann Antibody in the Serum of a Paroxysmal Hemoglobinuria , J. Path. & Bact. 26:196, 1923. 18. Puris, A. M.: Paroxysmal Hemoglobinuria , Am. J. Dis. Child. 37:1027 ( (May) ) 1929. 19. Maire, E. D.: Paroxysmal Hemoglobinuria Due to the Cold Hemolysin: Observations with a Report of a Case of Its Occurrence in an Aerial Gunner , Arch. Int. Med. 76:292 ( (Nov.-Dec.) ) 1945. 20. Harris, K. E.; Lewis, T., and Vaughan, J. M.: Haemoglobinuria and Urticaria from Cold Occurring Singly or in Combination: Observations Referring Especially to Mechanism of Urticaria with Some Remarks upon Raynaud's Disease , Heart 14:305 ( (March) ) 1929. 21. Stevenson, I. P.: Paroxysmal Hemoglobinuria with Report of a Case , McGill M. J. 12:192 ( (Oct.) ) 1943. 22. Dickson, J. G.: Paroxysmal Hemoglobinuria with Report of Case Followed for Thirteen Years , U. S. Nav. M. Bull. 34:300 ( (July) ) 1936. 23. Murri, A., cited by Mackenzie.4 24. Neurath, H.: False Positive Reactions in the Serology of Syphilis , J. Ven. Dis. Inform. , 1945, supp. 20, p. 134. 25. McCarthy, F. P., and Wilson, R., Jr.: Paroxysmal Hemoglobinuria: Report of Cases, with Familial Findings , New England J. Med. 207: 1019 ( (Dec. 8) ) 1932. 26. Kumagai, T., and Jnoue, B.: Beiträge zur Kenntnis der paroxysmalen Hämoglobinurie , Deutsche med. Wchnschr. 38:361, 1912.Crossref 27. Thurmon, F., and Blaine, D.: Paroyxsmal Hemoglobinuria: Observation Based upon Study of Three Cases , Am. J. Syph. 15:350 ( (July) ) 1931. 28. Woofter, A. C., and Parks, B. S.: Paroxysmal Hemoglobinuria with Report of Case , Ann. Int. Med. 12:402 ( (Sept.) ) 1938.Crossref 29. Ernstene and Gardner.10b 30. Lopes.10d McCombs 31. R. P., and McElroy, J. S.: Reversible Auto-Hemagglutination with Peripheral Vascular Symptoms , Arch. Int. Med. 59:107 ( (Jan.) ) 1937.Crossref 32. Roth, G.: Paroxysmal Hemoglobinuria with Vasomotor and Agglutinative Features , Proc. Staff Meet., Mayo Clin. 10:609 ( (Sept. 25) ) 1935. 33. Stats, D., and Bullowa, J. G. M.: Cold Hemagglutination with Symmetric Gangrene of the Tips of the Extremities: Report of Case , Arch. Int. Med. 72:506 ( (Oct.) ) 1943.Crossref 34. Moro, E.; Noda, S., and Benjamin, E.: Paroxysmale Hämoglobinurie und Hämolyse in Vitro , München. med. Wchnschr. 56:545, 1909. 35. Stats, D.: Cold Hemagglutination and Cold Hemolysis: Hemolysis Produced by Shaking Cold Agglutinated Erythrocytes , J. Clin. Investigation 24:33 ( (Jan.) ) 1945Crossref 36. Cold Agglutinated Erythrocytes: Hemolytic Effect of Shaking , Proc. Soc. Exper. Biol. & Med. 54:305 ( (Dec.) ) 1943. 37. Wintrobe, M. M.: Clinical Hematology , Philadelphia, Lea & Febiger, 1942, pp. 429-430. 38. Stats, D., and Wassermann, L. R.: Cold Hemagglutination—An Interpretive Review , Medicine 22:363 ( (Dec.) ) 1943. 39. Kumagai, T., and Namba, M.: Weitere Beiträge zur Kenntnis der paroxysmalen Hämoglobinurie , Deutsches Arch. f. klin. Med. 156:257, 1927. 40. Goldberg, L. C.: Treatment of Paroxysmal Hemoglobinuria with Penicillin , Am. J. Syph., Gonor. & Ven. Dis. 31:163 ( (March) ) 1947. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Internal Medicine American Medical Association

PAROXYSMAL COLD HEMOGLOBINURIAS

Archives of Internal Medicine , Volume 81 (5) – May 1, 1948

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American Medical Association
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Copyright © 1948 American Medical Association. All Rights Reserved.
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0730-188X
DOI
10.1001/archinte.1948.00220230028004
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Abstract

Abstract DRESSLER1 is credited with having first reported observations on a case of "paroxysmal cold hemoglobinuria," a symptom complex now known to have two separate and distinct etiologic bases. The first and more generally recognized type is syphilitic paroxysmal cold hemoglobinuria, a disease seen in a small percentage of persons with syphilis and caused by a cold-warm hemolysin unique to persons with syphilis with this disease. The second and nonsyphilitic type is cold hemagglutination paroxysmal hemoglobinuria, a disease accompanied with unusually high titers of cold hemagglutinins and first reported by Salén2 in 1935 when he recorded observations on pronounced cold agglutination of the red blood cells of a nonsyphilitic patient with paroxysmal cold hemoglobinuria. This paper will be concerned primarily with the syphilitic type of paroxysmal cold hemoglobinuria. Care was taken to avoid the error of including reports of cold hemagglutination paroxysmal hemoglobinuria in this review of cases of References 1. Dressler, cited by Macalister3 2. Mackenzie.4 3. Salén, E. B.: Thermostabiles, nicht komplexes (Auto-) Hämolysin bei transitorischer Kältehämoglobinurie , Acta med. Scandinav. 86:570, 1935.Crossref 4. Macalister, G. H. K.: The Pathology of Paroxysmal Hemoglobinuria: A Critical Review , Quart. J. Med. 2:368, 1908-1909. 5. Mackenzie, G. M.: Paroxysmal Hemoglobinuria: A Review , Medicine 8:159 ( (May) ) 1929.Crossref 6. Jones, B. B., and Jones, C. M.: Paroxysmal Hemoglobinuria , in Nelson Loose-Leaf Living Medicine , New York, Thos. Nelson & Sons, 1920-1929, vol. 4, p. 173A. 7. Howard, C. P.; Mills, F. S., and Townsend, S. R.: Paroxysmal Hemoglobinuria with Report of Case , Am. J. M. Sc. 196:772 ( (Dec.) ) 1938.Crossref 8. Donath, J., and Landsteiner, K.: Ueber paroxysmale Hämoglobinurie , München. med. Wchnschr. 51:1509, 1904. 9. Eason, J.: The Pathology of Paroxysmal Hæmoglobinuria,ia , J. Path. & Bact. 11:167, 1906. 10. Widal, F.; Abrami, P., and Brissaud, E.: Recherches sur l'hémoglobinurie paroxystique à frigore , Compt. rend. Soc. de biol. 65:429, 1913. 11. Donath, J., and Landsteiner, K.: Ueber Kältehämoglobinurie , Ergebn. d. Hyg. , Bakt. 7:184, 1925. 12. Ernstene, A. C., and Gardner, W. J.: The Effect of Splanchnic Nerve Resection and Sympathetic Ganglionectomy in a Case of Paroxysmal Hemoglobinuria , J. Clin. Investigation 14:799 ( (Nov.) ) 1935. 13. Roch, M. M., and Liengme, A.: Hémoglobinurie paroxystique et angine éryhthémateuse "a frigore," Bull. et mém. Soc. méd. d. hôp. de Paris 46:1737, 1922. 14. Lopes, D. M.: Hemoglobinuria paroxistica "a frigore," Brasil-med. 48:486 ( (Dec. 16-30) ) 1944. 15. York, W., and Macfie, J. W. S.: Mechanism of Autolysis in Paroxysmal Hemoglobinuria , Brit. J. Exper. Path. 2:115 ( (June) ) 1921. 16. Burmeister, J.: Ueber paroxysmale Hämoglubinurie and Syphilis , Ztschr. f. klin. Med. 92:19, 1921. 17. Smith, R. P.: The Relationship of the Autolysin and the Wassermann Antibody in the Serum of a Paroxysmal Hemoglobinuria , J. Path. & Bact. 26:196, 1923. 18. Puris, A. M.: Paroxysmal Hemoglobinuria , Am. J. Dis. Child. 37:1027 ( (May) ) 1929. 19. Maire, E. D.: Paroxysmal Hemoglobinuria Due to the Cold Hemolysin: Observations with a Report of a Case of Its Occurrence in an Aerial Gunner , Arch. Int. Med. 76:292 ( (Nov.-Dec.) ) 1945. 20. Harris, K. E.; Lewis, T., and Vaughan, J. M.: Haemoglobinuria and Urticaria from Cold Occurring Singly or in Combination: Observations Referring Especially to Mechanism of Urticaria with Some Remarks upon Raynaud's Disease , Heart 14:305 ( (March) ) 1929. 21. Stevenson, I. P.: Paroxysmal Hemoglobinuria with Report of a Case , McGill M. J. 12:192 ( (Oct.) ) 1943. 22. Dickson, J. G.: Paroxysmal Hemoglobinuria with Report of Case Followed for Thirteen Years , U. S. Nav. M. Bull. 34:300 ( (July) ) 1936. 23. Murri, A., cited by Mackenzie.4 24. Neurath, H.: False Positive Reactions in the Serology of Syphilis , J. Ven. Dis. Inform. , 1945, supp. 20, p. 134. 25. McCarthy, F. P., and Wilson, R., Jr.: Paroxysmal Hemoglobinuria: Report of Cases, with Familial Findings , New England J. Med. 207: 1019 ( (Dec. 8) ) 1932. 26. Kumagai, T., and Jnoue, B.: Beiträge zur Kenntnis der paroxysmalen Hämoglobinurie , Deutsche med. Wchnschr. 38:361, 1912.Crossref 27. Thurmon, F., and Blaine, D.: Paroyxsmal Hemoglobinuria: Observation Based upon Study of Three Cases , Am. J. Syph. 15:350 ( (July) ) 1931. 28. Woofter, A. C., and Parks, B. S.: Paroxysmal Hemoglobinuria with Report of Case , Ann. Int. Med. 12:402 ( (Sept.) ) 1938.Crossref 29. Ernstene and Gardner.10b 30. Lopes.10d McCombs 31. R. P., and McElroy, J. S.: Reversible Auto-Hemagglutination with Peripheral Vascular Symptoms , Arch. Int. Med. 59:107 ( (Jan.) ) 1937.Crossref 32. Roth, G.: Paroxysmal Hemoglobinuria with Vasomotor and Agglutinative Features , Proc. Staff Meet., Mayo Clin. 10:609 ( (Sept. 25) ) 1935. 33. Stats, D., and Bullowa, J. G. M.: Cold Hemagglutination with Symmetric Gangrene of the Tips of the Extremities: Report of Case , Arch. Int. Med. 72:506 ( (Oct.) ) 1943.Crossref 34. Moro, E.; Noda, S., and Benjamin, E.: Paroxysmale Hämoglobinurie und Hämolyse in Vitro , München. med. Wchnschr. 56:545, 1909. 35. Stats, D.: Cold Hemagglutination and Cold Hemolysis: Hemolysis Produced by Shaking Cold Agglutinated Erythrocytes , J. Clin. Investigation 24:33 ( (Jan.) ) 1945Crossref 36. Cold Agglutinated Erythrocytes: Hemolytic Effect of Shaking , Proc. Soc. Exper. Biol. & Med. 54:305 ( (Dec.) ) 1943. 37. Wintrobe, M. M.: Clinical Hematology , Philadelphia, Lea & Febiger, 1942, pp. 429-430. 38. Stats, D., and Wassermann, L. R.: Cold Hemagglutination—An Interpretive Review , Medicine 22:363 ( (Dec.) ) 1943. 39. Kumagai, T., and Namba, M.: Weitere Beiträge zur Kenntnis der paroxysmalen Hämoglobinurie , Deutsches Arch. f. klin. Med. 156:257, 1927. 40. Goldberg, L. C.: Treatment of Paroxysmal Hemoglobinuria with Penicillin , Am. J. Syph., Gonor. & Ven. Dis. 31:163 ( (March) ) 1947.

Journal

Archives of Internal MedicineAmerican Medical Association

Published: May 1, 1948

References