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PARIS

PARIS Cortisone and Gestation. —Several years ago, Prof. Robert Courrier, general secretary to the Academy of Sciences, studied the influence of desoxycorticosterone on the gestation of rabbits. He found that this substance can replace the corpus luteum hormone; it allows the evolution of pregnancy in the castrated pregnant animal. Recently, in collaboration with Mme. Andrée Collonge, Professor Courrier studied the effect of cortisone on gestation. Rabbits were given daily injections of 25 mg. of cortisone acetate, dissolved in 1 cc. of an excipient, during four to seven days, between the 10th and the 23d days of gestation. This experiment gave the following results: Some rabbits aborted; with separation of the placenta; in others a hemorrhage occurred. When injections were given between the 10th and 14th days of pregnancy, autopsy revealed, besides living fetuses, evidences of resorbed ones; fetuses were diminished in size, from 24 to 20 mm., and placentas were pale. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA American Medical Association

PARIS

JAMA , Volume 146 (5) – Jun 2, 1951

PARIS

Abstract



Cortisone and Gestation.
—Several years ago, Prof. Robert Courrier, general secretary to the Academy of Sciences, studied the influence of desoxycorticosterone on the gestation of rabbits. He found that this substance can replace the corpus luteum hormone; it allows the evolution of pregnancy in the castrated pregnant animal. Recently, in collaboration with Mme. Andrée Collonge, Professor Courrier studied the effect of cortisone on gestation. Rabbits were given daily injections...
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Publisher
American Medical Association
Copyright
Copyright © 1951 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
0098-7484
eISSN
1538-3598
DOI
10.1001/jama.1951.03670050075022
Publisher site
See Article on Publisher Site

Abstract

Cortisone and Gestation. —Several years ago, Prof. Robert Courrier, general secretary to the Academy of Sciences, studied the influence of desoxycorticosterone on the gestation of rabbits. He found that this substance can replace the corpus luteum hormone; it allows the evolution of pregnancy in the castrated pregnant animal. Recently, in collaboration with Mme. Andrée Collonge, Professor Courrier studied the effect of cortisone on gestation. Rabbits were given daily injections of 25 mg. of cortisone acetate, dissolved in 1 cc. of an excipient, during four to seven days, between the 10th and the 23d days of gestation. This experiment gave the following results: Some rabbits aborted; with separation of the placenta; in others a hemorrhage occurred. When injections were given between the 10th and 14th days of pregnancy, autopsy revealed, besides living fetuses, evidences of resorbed ones; fetuses were diminished in size, from 24 to 20 mm., and placentas were pale.

Journal

JAMAAmerican Medical Association

Published: Jun 2, 1951

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