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Parapapillary Chorioretinal Atrophy in Patients With Ocular Hypertension: II. An Evaluation of Progressive Changes

Parapapillary Chorioretinal Atrophy in Patients With Ocular Hypertension: II. An Evaluation of... Abstract Objective: To determine whether parapapillary chorioretinal atrophy in patients with ocular hypertension remained stationary or progressed along with glaucomatous optic nerve damage. Methods: The morphometric parameters and progression of parapapillary atrophy were retrospectively investigated, using serial photographs, in 350 eyes of 175 patients with ocular hypertension. The association of parapapillary atrophy progression with subsequent glaucomatous conversion and with other baseline patientand eye-specific characteristics was analyzed. Results: Progression in the area and extension of parapapillary atrophy before noticeable optic disc or visual field changes was observed in 48 (49.0%) of 98 eyes that converted to glaucoma, while parapapillary atrophy progression was noted in 25 (9.9%) of 252 ocular hypertensive eyes that did not develop glaucomatous damage (P<.001). The predictive sensitivity and specificity of this observation were 49% and 90%, respectively. In a logistic multiple regression model, the progression of parapapillary atrophy was associated with a family history of glaucoma (odds ratio, 2.7) and the initial size of zone β (odds ratio, 1.64, for an increase of 0.10 of the zone β area—disc area ratio). Conclusion: The progression of parapapillary chorioretinal atrophy may be an early glaucomatous finding in some patients with ocular hypertension. References 1. Motolko M, Drance SM. Features of the optic disc in preglaucomatous eyes . Arch Ophthalmol . 1981;99:1992-1994.Crossref 2. Kasner O, Feuer WJ, Anderson DR. Possibly reduced prevalence of peripapillary crescents in ocular hypertension . Can J Ophthalmol . 1989;24:211-215. 3. Buus DR, Anderson DR. Peripapillary crescent and halos in normal-tension glaucoma and ocular hypertension . Ophthalmology . 1989;96:16-19.Crossref 4. Airaksinen PJ, Tuulonen A, Alanko HI. Prediction of development of glaucoma in ocular hypertensive patients . In: Krieglstein GK, ed. Glaucoma Update IV . New York, NY: Springer-Verlag NY Inc; 1991:183-186. 5. Quigley HA, Enger C, Katz J, Sommer A, Scott R, Gilbert D. Risk factors for the development of glaucomatous visual field loss in ocular hypertension . Arch Ophthalmol . 1994;112:644-649.Crossref 6. Stewart WC, Connor AB, Wang X. Anatomic features of the optic disc and risk of progression in ocular hypertension . Acta Ophthalmol Scand . 1995;73:237-241.Crossref 7. Tezel G, Kass MA, Kolker AE, Wax MB. Comparative analysis of optic disc parameters in normal pressure glaucoma, primary open angle glaucoma and ocular hypertension . Ophthalmology . 1996;103:2105-2113.Crossref 8. Tsai CS, Ritch R, Shin DH, Wan JY, Chi Y. Age related decline of disc rim area in visually normal subjects . Ophthalmology . 1992;99:29-35.Crossref 9. Jonas JB, Fernandez MC, Naumann GOH. Glaucomatous parapapillary atrophy: occurence and correlations . Arch Ophthalmol . 1992;110:214-222.Crossref 10. Liang KY, Zeger SL. Longitudinal data analysis using generalized linear models . Biometrika . 1986;73:13-22.Crossref 11. Zeger SL, Liang KY. The analysis of discrete and continuous longitudinal data . Biometrics . 1986;42:121-130.Crossref 12. Kubota T, Jonas JB, Naumann GOH. Direct clinico-histological correlations of parapapillary chorioretinal atrophy . Br J Ophthamol . 1993;77:103-106.Crossref 13. Kubota T, Schlötzer-Schrehatdt UM, Naumann GOH, Kohno T, Inomata H. The ultrastructure of parapapillary chorioretinal atrophy in eyes with secondary angle-closure glaucoma . Graefes Arch Clin Exp Ophthalmol . 1996;234:351-358.Crossref 14. Korete GE, Reppucci V, Henkind P. Retinal pigment epithelium destruction causes chorioretinal atrophy . Invest Ophthalmol Vis Sci . 1984;25:1135-1145. 15. Airaksinen PJ, Juvala PA, Tuulonen A, et al. Change of peripapillary atrophy in glaucoma . In: Krieglstein GK, ed. Glaucoma Update III . New York, NY: Springer-Verlag NY Inc; 1987:97-102. 16. Rockwood EJ, Anderson DR. Acquired peripapillary changes and progression in glaucoma . Graefes Arch Clin Exp Ophthalmol . 1988;226:510-515.Crossref 17. Jonas JB, Papastathopoulos KI. Pressure-dependent changes of the optic disc in primary open-angle glaucoma . Am J Ophthalmol . 1995;119:313-317. 18. Cioffi GA, Van Buskirk M. Microvasculature of the anterior optic nerve . Surv Ophthalmol . 1994;38( (suppl) ):107-117.Crossref 19. Hayreh SS. In vivo choroidal circulation and its watershed zones . Eye . 1990;4:273-289.Crossref 20. Kellerman L, Posner A. The value of heredity in the detection and study of glaucoma . Am J Ophthalmol . 1955;40:681-685. 21. Becker B, Kolker AE, Roth FD. Glaucoma family study . Am J Ophthalmol . 1960;50:557-567. 22. Shin DH, Becker B, Kolker AE. Family history in primary open-angle glaucoma . Arch Ophthalmol . 1977;95:598-600.Crossref 23. Tielsch JM, Katz J, Sommer A, Quigley HA, Javitt JC. Family history and risk of primary open angle glaucoma . Arch Ophthalmol . 1994;112:69-73.Crossref 24. Best M, Toyofuku H. Ocular hemodynamics during ocular hypertension in man . Am J Ophthalmol . 1972;74:932-939. 25. Hayreh SS, Zimmerman MB, Podhajsky P, Alward WLM. Nocturnal arterial hypotension and its role in optic nerve head and ocular ischemic disorders . Am J Ophthalmol . 1994;117:603-624. 26. Hayreh SS, Walker WM. Fluorescent fundus photography in glaucoma . Am J Ophthalmol . 1967;63:982-989. 27. Raitta C, Sarmela T. Fluorescein angiography of the optic disc and the peripapillary area in chronic glaucoma . Acta Ophthalmol (Copenh) . 1970;48:303-308.Crossref 28. Ulrich A, Ulrich C, Barth T, Ulrich WD. Detection of disturbed autoregulation of the peripapillary choroid in primary open angle glaucoma . Ophthalmic Surg Lasers . 1996;27:746-757. 29. Armaly MF, Krueger DE, Maunder L, et al. Biostatistical analysis of the collaborative glaucoma study, I . Arch Ophthalmol . 1980;98:2163-2171.Crossref 30. Drance SM, Schulzer M, Thomas B, Douglas GR. Multivariate analysis in glaucoma . Arch Ophthalmol . 1981;99:1019-1022.Crossref 31. Airaksinen PJ, Tuulonen A, Alanko HI. Rate and pattern of neuroretinal rim area decrease in ocular hypertension and glaucoma . Arch Ophthalmol . 1992;110:206-210.Crossref 32. Pederson JE, Anderson DR. The mode of progressive disc cupping in ocular hypertension and glaucoma . Arch Ophthalmol . 1980;98:490-495.Crossref 33. Sommer A, Quigley HA, Robin AL, Miller NR, Katz J, Arkell S. Evaluation of nerve fiber layer assessment . Arch Ophthalmol . 1984;102:1766-1771.Crossref 34. Sommer A, Katz J, Quigley HA, et al. Clinically detectable nerve fiber atrophy precedes the onset of glaucomatous field loss . Arch Ophthalmol . 1991;109:77-83.Crossref 35. Goldman H. Some basic problems of simple glaucoma . Am J Ophthalmol . 1959;48:213-220. 36. Iwata K. Ophthalmoscopy in the detection of optic disc and retinal nerve fiber layer changes in early glaucoma . Surv Ophthalmol . 1989;33:447-448.Crossref 37. Bengtsson B. Optic disc haemorrhages preceding manifest glaucoma . Acta Ophthalmol (Copenh) . 1990;68:450-454.Crossref 38. Hart WM, Yablonski M, Kass MA, Becker B. Multivariate analysis of the risk of glaucomatous visual field loss . Arch Ophthalmol . 1979;97:1455-1458.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Ophthalmology American Medical Association

Parapapillary Chorioretinal Atrophy in Patients With Ocular Hypertension: II. An Evaluation of Progressive Changes

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Publisher
American Medical Association
Copyright
Copyright © 1997 American Medical Association. All Rights Reserved.
ISSN
0003-9950
eISSN
1538-3687
DOI
10.1001/archopht.1997.01100160679003
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Abstract

Abstract Objective: To determine whether parapapillary chorioretinal atrophy in patients with ocular hypertension remained stationary or progressed along with glaucomatous optic nerve damage. Methods: The morphometric parameters and progression of parapapillary atrophy were retrospectively investigated, using serial photographs, in 350 eyes of 175 patients with ocular hypertension. The association of parapapillary atrophy progression with subsequent glaucomatous conversion and with other baseline patientand eye-specific characteristics was analyzed. Results: Progression in the area and extension of parapapillary atrophy before noticeable optic disc or visual field changes was observed in 48 (49.0%) of 98 eyes that converted to glaucoma, while parapapillary atrophy progression was noted in 25 (9.9%) of 252 ocular hypertensive eyes that did not develop glaucomatous damage (P<.001). The predictive sensitivity and specificity of this observation were 49% and 90%, respectively. In a logistic multiple regression model, the progression of parapapillary atrophy was associated with a family history of glaucoma (odds ratio, 2.7) and the initial size of zone β (odds ratio, 1.64, for an increase of 0.10 of the zone β area—disc area ratio). Conclusion: The progression of parapapillary chorioretinal atrophy may be an early glaucomatous finding in some patients with ocular hypertension. References 1. Motolko M, Drance SM. Features of the optic disc in preglaucomatous eyes . Arch Ophthalmol . 1981;99:1992-1994.Crossref 2. Kasner O, Feuer WJ, Anderson DR. Possibly reduced prevalence of peripapillary crescents in ocular hypertension . Can J Ophthalmol . 1989;24:211-215. 3. Buus DR, Anderson DR. Peripapillary crescent and halos in normal-tension glaucoma and ocular hypertension . Ophthalmology . 1989;96:16-19.Crossref 4. Airaksinen PJ, Tuulonen A, Alanko HI. Prediction of development of glaucoma in ocular hypertensive patients . In: Krieglstein GK, ed. Glaucoma Update IV . New York, NY: Springer-Verlag NY Inc; 1991:183-186. 5. Quigley HA, Enger C, Katz J, Sommer A, Scott R, Gilbert D. Risk factors for the development of glaucomatous visual field loss in ocular hypertension . Arch Ophthalmol . 1994;112:644-649.Crossref 6. Stewart WC, Connor AB, Wang X. Anatomic features of the optic disc and risk of progression in ocular hypertension . Acta Ophthalmol Scand . 1995;73:237-241.Crossref 7. Tezel G, Kass MA, Kolker AE, Wax MB. Comparative analysis of optic disc parameters in normal pressure glaucoma, primary open angle glaucoma and ocular hypertension . Ophthalmology . 1996;103:2105-2113.Crossref 8. Tsai CS, Ritch R, Shin DH, Wan JY, Chi Y. Age related decline of disc rim area in visually normal subjects . Ophthalmology . 1992;99:29-35.Crossref 9. Jonas JB, Fernandez MC, Naumann GOH. Glaucomatous parapapillary atrophy: occurence and correlations . Arch Ophthalmol . 1992;110:214-222.Crossref 10. Liang KY, Zeger SL. Longitudinal data analysis using generalized linear models . Biometrika . 1986;73:13-22.Crossref 11. Zeger SL, Liang KY. The analysis of discrete and continuous longitudinal data . Biometrics . 1986;42:121-130.Crossref 12. Kubota T, Jonas JB, Naumann GOH. Direct clinico-histological correlations of parapapillary chorioretinal atrophy . Br J Ophthamol . 1993;77:103-106.Crossref 13. Kubota T, Schlötzer-Schrehatdt UM, Naumann GOH, Kohno T, Inomata H. The ultrastructure of parapapillary chorioretinal atrophy in eyes with secondary angle-closure glaucoma . Graefes Arch Clin Exp Ophthalmol . 1996;234:351-358.Crossref 14. Korete GE, Reppucci V, Henkind P. Retinal pigment epithelium destruction causes chorioretinal atrophy . Invest Ophthalmol Vis Sci . 1984;25:1135-1145. 15. Airaksinen PJ, Juvala PA, Tuulonen A, et al. Change of peripapillary atrophy in glaucoma . In: Krieglstein GK, ed. Glaucoma Update III . New York, NY: Springer-Verlag NY Inc; 1987:97-102. 16. Rockwood EJ, Anderson DR. Acquired peripapillary changes and progression in glaucoma . Graefes Arch Clin Exp Ophthalmol . 1988;226:510-515.Crossref 17. Jonas JB, Papastathopoulos KI. Pressure-dependent changes of the optic disc in primary open-angle glaucoma . Am J Ophthalmol . 1995;119:313-317. 18. Cioffi GA, Van Buskirk M. Microvasculature of the anterior optic nerve . Surv Ophthalmol . 1994;38( (suppl) ):107-117.Crossref 19. Hayreh SS. In vivo choroidal circulation and its watershed zones . Eye . 1990;4:273-289.Crossref 20. Kellerman L, Posner A. The value of heredity in the detection and study of glaucoma . Am J Ophthalmol . 1955;40:681-685. 21. Becker B, Kolker AE, Roth FD. Glaucoma family study . Am J Ophthalmol . 1960;50:557-567. 22. Shin DH, Becker B, Kolker AE. Family history in primary open-angle glaucoma . Arch Ophthalmol . 1977;95:598-600.Crossref 23. Tielsch JM, Katz J, Sommer A, Quigley HA, Javitt JC. Family history and risk of primary open angle glaucoma . Arch Ophthalmol . 1994;112:69-73.Crossref 24. Best M, Toyofuku H. Ocular hemodynamics during ocular hypertension in man . Am J Ophthalmol . 1972;74:932-939. 25. Hayreh SS, Zimmerman MB, Podhajsky P, Alward WLM. Nocturnal arterial hypotension and its role in optic nerve head and ocular ischemic disorders . Am J Ophthalmol . 1994;117:603-624. 26. Hayreh SS, Walker WM. Fluorescent fundus photography in glaucoma . Am J Ophthalmol . 1967;63:982-989. 27. Raitta C, Sarmela T. Fluorescein angiography of the optic disc and the peripapillary area in chronic glaucoma . Acta Ophthalmol (Copenh) . 1970;48:303-308.Crossref 28. Ulrich A, Ulrich C, Barth T, Ulrich WD. Detection of disturbed autoregulation of the peripapillary choroid in primary open angle glaucoma . Ophthalmic Surg Lasers . 1996;27:746-757. 29. Armaly MF, Krueger DE, Maunder L, et al. Biostatistical analysis of the collaborative glaucoma study, I . Arch Ophthalmol . 1980;98:2163-2171.Crossref 30. Drance SM, Schulzer M, Thomas B, Douglas GR. Multivariate analysis in glaucoma . Arch Ophthalmol . 1981;99:1019-1022.Crossref 31. Airaksinen PJ, Tuulonen A, Alanko HI. Rate and pattern of neuroretinal rim area decrease in ocular hypertension and glaucoma . Arch Ophthalmol . 1992;110:206-210.Crossref 32. Pederson JE, Anderson DR. The mode of progressive disc cupping in ocular hypertension and glaucoma . Arch Ophthalmol . 1980;98:490-495.Crossref 33. Sommer A, Quigley HA, Robin AL, Miller NR, Katz J, Arkell S. Evaluation of nerve fiber layer assessment . Arch Ophthalmol . 1984;102:1766-1771.Crossref 34. Sommer A, Katz J, Quigley HA, et al. Clinically detectable nerve fiber atrophy precedes the onset of glaucomatous field loss . Arch Ophthalmol . 1991;109:77-83.Crossref 35. Goldman H. Some basic problems of simple glaucoma . Am J Ophthalmol . 1959;48:213-220. 36. Iwata K. Ophthalmoscopy in the detection of optic disc and retinal nerve fiber layer changes in early glaucoma . Surv Ophthalmol . 1989;33:447-448.Crossref 37. Bengtsson B. Optic disc haemorrhages preceding manifest glaucoma . Acta Ophthalmol (Copenh) . 1990;68:450-454.Crossref 38. Hart WM, Yablonski M, Kass MA, Becker B. Multivariate analysis of the risk of glaucomatous visual field loss . Arch Ophthalmol . 1979;97:1455-1458.Crossref

Journal

Archives of OphthalmologyAmerican Medical Association

Published: Dec 1, 1997

References