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Paraneoplastic Encephalomyelitis and Neuropathy: Report of a Case

Paraneoplastic Encephalomyelitis and Neuropathy: Report of a Case Abstract • A 47-year-old woman displayed rapidly worsening cerebellar degeneration, bulbar encephalitis, and peripheral neuropathy four years after radical mastectomy and a course of systemic chemotherapy for breast cancer. Progressive neurologic deterioration over a period of one year ended with her death from intercurrent infection. Postmortem examination failed to reveal any recurrent neoplasm, but neuropathologic study revealed cerebellar degeneration and bulbar encephalitis consistent with paraneoplastic disease. References 1. Brain L, Wilkinson M: Subacute cerebellar degeneration associated with neoplasms . Brain 1965;88:465-478.Crossref 2. Crosley CJ, Rorke LB, Evans A, et al: Central nervous system lesions in childhood leukemia . Neurology 1978;28:678-685.Crossref 3. Meadows AT, Evans AE: Effects of chemotherapy on the central nervous system . Cancer 1976;37:1079-1085.Crossref 4. Norrell H, Wilson CB, Slagel DE, et al: Leukoencephalopathy following the administration of methotrexate into the cerebrospinal fluid in the treatment of primary brain tumors . Cancer 1974;33:923-932.Crossref 5. Price RA, Jamieson PA: The central nervous system in childhood leukemia . Cancer 1975;35:306-318.Crossref 6. Rubinstein LJ, Herman MM, Long TF, et al: Disseminated necrotizing leukoencephalopathy: A complication of treated central nervous system leukemia and lymphoma . Cancer 1975;35:291-305.Crossref 7. Dorfman LJ, Forno LS: Paraneoplastic encephalomyelitis . Acta Neurol Scand 1972;48:556-574.Crossref 8. Henson RA, Hoffman HL, Urich H: Encephalomyelitis with carcinoma . Brain 1965;88:449-464.Crossref 9. Vick N, Schulman S, Dau P: Carcinomatous cerebellar degeneration, encephalomyelitis, and sensory neuropathy (radiculitis) . Neurology 1969;19:425-441.Crossref 10. Castaigne P, Buge A, Escourolle R, et al: L'atrophie cerebelleuse paraneoplastique . Presse Med 1964;72:2639-2644. 11. Julien J, Vital CL, Vallat JM: Atrophie cerebelleuse para-neoplastique . Bordeaux Med 1972;5:2461-2467. 12. Sarbach B: L'atteinte paraneoplastique du cervelet: Etude anatomo-clinique d'un cas porteur d'une atrophie corticale et de lesions inflammatoires des noyaux denteles . Acta Neurol Belg 1977;77:362-363. 13. Vincent FM: Paraneoplastic CNS and renal syndromes . JAMA 1978;240:862-863.Crossref 14. Satoyoshi E, Kowa H, Fukunaga N: Subacute cerebellar degeneration and Eaton-Lambert syndrome with bronchogenic carcinoma: A case report . Neurology 1973;23:764-768.Crossref 15. Schmid AH, Riede UN: A morphometric study of the cerebellar cortex from patients with carcinoma: A contribution on quantitative aspects in carcinotoxic cerebellar atrophy . Acta Neuropathol 1974;28:343-352.Crossref 16. Valtysson G, Fisher-Beckfield P, Carbone PP: Cerebellar degeneration with Hodgkin's disease . CA 1979;29:246-249. 17. Adams JH: Virus diseases of the nervous system : in Blackwood W, Corsellis JAN (eds): Greenfield's Neuropathology , ed 3. Chicago, Year Book Medical Publishers, 1976, pp 317-321. 18. Trotter JL, Hendin BA, Osterland CK: Cerebellar degeneration with Hodgkin disease: An immunological study . Acta Neurol 1976;33:660-661. 19. Horwich MS, Cho L, Porro RS, et al: Subacute sensory neuropathy: A remote effect of carcinoma . Ann Neurol 1977;2;7-19.Crossref 20. Johnson PC, Rolak LA, Hamilton RH, et al: Paraneoplastic vasculitis of nerve: A remote effect of cancer . Ann Neurol 1979;5:437-444.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Neurology American Medical Association

Paraneoplastic Encephalomyelitis and Neuropathy: Report of a Case

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Publisher
American Medical Association
Copyright
Copyright © 1981 American Medical Association. All Rights Reserved.
ISSN
0003-9942
eISSN
1538-3687
DOI
10.1001/archneur.1981.00510120073012
Publisher site
See Article on Publisher Site

Abstract

Abstract • A 47-year-old woman displayed rapidly worsening cerebellar degeneration, bulbar encephalitis, and peripheral neuropathy four years after radical mastectomy and a course of systemic chemotherapy for breast cancer. Progressive neurologic deterioration over a period of one year ended with her death from intercurrent infection. Postmortem examination failed to reveal any recurrent neoplasm, but neuropathologic study revealed cerebellar degeneration and bulbar encephalitis consistent with paraneoplastic disease. References 1. Brain L, Wilkinson M: Subacute cerebellar degeneration associated with neoplasms . Brain 1965;88:465-478.Crossref 2. Crosley CJ, Rorke LB, Evans A, et al: Central nervous system lesions in childhood leukemia . Neurology 1978;28:678-685.Crossref 3. Meadows AT, Evans AE: Effects of chemotherapy on the central nervous system . Cancer 1976;37:1079-1085.Crossref 4. Norrell H, Wilson CB, Slagel DE, et al: Leukoencephalopathy following the administration of methotrexate into the cerebrospinal fluid in the treatment of primary brain tumors . Cancer 1974;33:923-932.Crossref 5. Price RA, Jamieson PA: The central nervous system in childhood leukemia . Cancer 1975;35:306-318.Crossref 6. Rubinstein LJ, Herman MM, Long TF, et al: Disseminated necrotizing leukoencephalopathy: A complication of treated central nervous system leukemia and lymphoma . Cancer 1975;35:291-305.Crossref 7. Dorfman LJ, Forno LS: Paraneoplastic encephalomyelitis . Acta Neurol Scand 1972;48:556-574.Crossref 8. Henson RA, Hoffman HL, Urich H: Encephalomyelitis with carcinoma . Brain 1965;88:449-464.Crossref 9. Vick N, Schulman S, Dau P: Carcinomatous cerebellar degeneration, encephalomyelitis, and sensory neuropathy (radiculitis) . Neurology 1969;19:425-441.Crossref 10. Castaigne P, Buge A, Escourolle R, et al: L'atrophie cerebelleuse paraneoplastique . Presse Med 1964;72:2639-2644. 11. Julien J, Vital CL, Vallat JM: Atrophie cerebelleuse para-neoplastique . Bordeaux Med 1972;5:2461-2467. 12. Sarbach B: L'atteinte paraneoplastique du cervelet: Etude anatomo-clinique d'un cas porteur d'une atrophie corticale et de lesions inflammatoires des noyaux denteles . Acta Neurol Belg 1977;77:362-363. 13. Vincent FM: Paraneoplastic CNS and renal syndromes . JAMA 1978;240:862-863.Crossref 14. Satoyoshi E, Kowa H, Fukunaga N: Subacute cerebellar degeneration and Eaton-Lambert syndrome with bronchogenic carcinoma: A case report . Neurology 1973;23:764-768.Crossref 15. Schmid AH, Riede UN: A morphometric study of the cerebellar cortex from patients with carcinoma: A contribution on quantitative aspects in carcinotoxic cerebellar atrophy . Acta Neuropathol 1974;28:343-352.Crossref 16. Valtysson G, Fisher-Beckfield P, Carbone PP: Cerebellar degeneration with Hodgkin's disease . CA 1979;29:246-249. 17. Adams JH: Virus diseases of the nervous system : in Blackwood W, Corsellis JAN (eds): Greenfield's Neuropathology , ed 3. Chicago, Year Book Medical Publishers, 1976, pp 317-321. 18. Trotter JL, Hendin BA, Osterland CK: Cerebellar degeneration with Hodgkin disease: An immunological study . Acta Neurol 1976;33:660-661. 19. Horwich MS, Cho L, Porro RS, et al: Subacute sensory neuropathy: A remote effect of carcinoma . Ann Neurol 1977;2;7-19.Crossref 20. Johnson PC, Rolak LA, Hamilton RH, et al: Paraneoplastic vasculitis of nerve: A remote effect of cancer . Ann Neurol 1979;5:437-444.Crossref

Journal

Archives of NeurologyAmerican Medical Association

Published: Dec 1, 1981

References