Abstract • We present a new method for the outpatient use of anthralin paste in the treatment of psoriasis. By instructing the patient to cover the nightly paste application with semipermeable paper tape, we devised a practical and easy method for home therapy. In a study of 12 patients with unresponsive plaque-type psoriasis, six responded with 90% or better clearing of treated sites and two with 70% clearing, compared with symmetrical control sites. Four patients showed no substantial improvement. The average duration of therapy was 11 weeks. A three-month reevaluation of the conditions of these patients disclosed that improvement had been substantially maintained. Despite the tape occlusion, irritation was a manageable problem, except in three patients who had to halt therapy. Although less effective than conventional inpatient anthralin paste regimens, this method is more cost-effective for those with limited plaque disease. (Arch Dermatol 1984;120:625-630) References 1. Farber EM, Harris DR: Hospital treatment of psoriasis: A modified anthralin program . Arch Dermatol 1970;101:381-389.Crossref 2. Harris DR: Stiff anthralin paste in the treatment of psoriasis . Cutis 1972;10:621-628. 3. Comaish S: Ingram method of treating psoriasis . Arch Dermatol 1965;92:56-58.Crossref 4. Champion RH: Treatment of psoriasis . Br Med J 1966;2:993-995.Crossref 5. Seville RH: Must psoriasis be chronic? Practitioner 1977;219:833-839. 6. Seville RH: Relapse rate of psoriasis worsened by adding steroids to a dithranol regime . Br J Dermatol 1976;95:643-646.Crossref 7. Seville RH: Simplified dithranol treatment for psoriasis . Br J Dermatol 1975;93:205-208.Crossref 8. Rogers S, Marks J, Shuster S, et al: Comparison of photochemotherapy and dithranol in the treatment of chronic plaque psoriasis . Lancet 1979;1:455-458.Crossref 9. Marriott PJ, Munro DD: Clobetasol propionate ointment compared with dithranol in Lassar's paste in the treatment of psoriasis . Br J Dermatol 1976;94:101-106.Crossref 10. Larkõ O, Swanbeck G: Home solarium treatment of psoriasis . Br J Dermatol 1979;101:13-16.Crossref 11. Cripps DJ, Lowe NJ: Photochemotherapy for psoriasis remission times: Psoralens and UV-A and combined photochemotherapy with anthralin . Clin Exp Dermatol 1979;4:447-483. 12. Fry L, Almeyda J, McMinn RM: Effect of plastic occlusive dressings on psoriatic epidermis . Br J Dermatol 1970;82:458-462.Crossref 13. Gay MW, Moore WJ, Morgan JM, et al: Anthralin toxicity . Arch Dermatol 1972;105:213-215.Crossref 14. Swanbeck G, Thyresson N: Interaction between dithranol and nucleic acids: A possible mechanism for the effect of dithranol on psoriasis . Acta DermVenereol 1965;45:344-348. 15. Swanbeck G, Lidén S: The inhibitory effect of dithranol (anthralin) on DNA synthesis . Acta DermVenereol 1966;46:228-230. 16. Segal A, Katz C, Van Duuren BL: Structure and tumor-promoting activity of anthralin (1,8-dihydroxy-9-anthrone) and related compounds . J Med Chem 1971;14:1152-1154.Crossref 17. Yasuhira K: Skin papilloma production by anthralin painting after urethan initiation in mice . Gann 1968;59:187-193. 18. Yasuhira K: Induction of malignant lymphoma and other tumors during experiments with anthralin painting of mice . Gann 1968;59:195-200. 19. McCann J, Choi E, Yamasaki E, et al: Detection of carcinogens as mutagens in the Salmonella microsome test: Assay of 300 chemicals . Proc Natl Acad Sci USA 1975;72:5135-5139.Crossref 20. Hakim RE, Griffin AC, Knox JA: Erythema and tumor formation in methoxsalen-treated mice exposed to fluorescent light . Arch Dermatol 1960;82:572-577.Crossref 21. Stern RS, Thibodeau LA, Kleinerman RA, et al: Risk of cutaneous carcinoma in patients treated with oral methoxsalen photochemotherapy for psoriasis . N Engl J Med 1979;300:809-813.Crossref 22. Pathak MA, Epstein JH: Normal and abnormal reactions of man to light , in Fitzpatrick TB, Arndt KA, Clark WH Jr, et al (eds): Dermatology in General Medicine , ed 1. New York, McGraw-Hill Book Co, 1971, pp 977-1036. 23. Wilkinson DS: Topical therapy , in Rook AR, Wilkinson DS, Ebling FJG (eds): Textbook of Dermatology , ed 2. Oxford, England, Blackwell Scientific Publications, 1972, pp 2063-2087.
Archives of Dermatology – American Medical Association
Published: May 1, 1984
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