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PANCREATIC FUNCTION: II. THE PANCREATIC ACTIVITY IN DIABETES MELLITUS

PANCREATIC FUNCTION: II. THE PANCREATIC ACTIVITY IN DIABETES MELLITUS Abstract In 1788, Cawley1 reported an intimate relationship between the sugar-regulating function and the pancreas and considered pancreatic disease an important factor in the etiology of diabetes. This was confirmed by various workers, such as Bright, Bouchardat, Friedreich, Bamberger, Frerichs, Senator, Seegen and others. The reports, however, were not more than statistical statements until Lancéraux (1877), on the basis of many clinical and anatomic observations, described a special form of diabetes called diabète pancréatique or diabète maigre. This form is characterized by a sudden onset, a malignant course and a special tendency to the complication of tuberculosis. The epoch-making discovery of von Mering and Minkowski2 in 1889, as well as the independent observations of N. de Dominicis,3 that complete extirpation of the pancreas in dogs always caused pronounced glycosuria, had made a marked effect on the development of the investigation of diabetes. Following the suggestion of Lancéraux, Bouchard and Gilbert in References 1. Labbé and Réchard: Les troubles de la sécrétion externe du pancréas dans le diabète sucré , Arch. d. mal. d. l'app. digestif 16:867, 1926. 2. Von Mering, J., and Minkowski, O.: Diabetes nach Pankreasexstirpation , Zentralbl. f. klin. Med. , 1889, p. 393 3. Arch. f. exper. Path. u. Pharmakol. 26:371, 1889. 4. De Dominicis: Studiisperim. intorno agli effeti delle estirpazione del pancreas , Gior. int. delle sc. med. , 1889, p. 801. 5. Opie, E. T.: Diabetes Mellitus Associated with Hyaline Degeneration of the Islands of Langerhans of the Pancreas , Bull. Johns Hopkins Hosp. 12:263, 1901. 6. Weichselbaum, A., and Stangl, E.: Zur Kenntnis der feineren Veränderungen des Pankreas bei Diabetes Mellitus , Wien. klin. Wchnschr. 14:968, 1901. 7. Banting, F. G., and Best, C. H.: The Internal Secretion of the Pancreas , J. Lab. & Clin. Med. 7:251 ( (Feb.) ) 1922. 8. Macleod, J. J. R.: The Source of Insulin , J. Metab. Research 2:149, 1922. 9. Allen, F. M.: The Pathology of Diabetes , J. Metab. Research 1:165, 1922. 10. Joslin, E. P.: The Treatment of Diabetes Mellitus , ed. 3, Philadelphia, Lea & Febiger, 1923, p. 137. 11. Okada, S.: Ueber die Pankreassekretion bei Sekretionsstörungen des Magens , Mitt. d. med. Fak. d. Kaiserl. Univ. z. Tokyo 13:157, 1914. 12. Von Noorden: Die Zuckerkrankheit , ed. 7, 1915. 13. Katsch, G., and Friedrich, L. v.: Bauchspeichelfluss auf Aetherreiz , Klin. Wchnschr. 1:112, 1922. 14. Langanke, E.: Untersuchungen über die Fermente des Pankreas vor und nach Injektion von Aether ins Duodenum , Klin. Wchnschr. 1:1458, 1922. 15. Jones, C. M.; Castle, W. B.; Mulholland, H. B., and Bailey, F.: Pancreatic and Hepatic Activity in Diabetes Mellitus , Arch. Int. Med. 35:315 ( (March) ) 1925. 16. Bargy, R.: Insuffisance pancreatique externe chez les diabetiques, étudiée par l'evaluation de l'activité fermentaire dans le liquide duodenal , Thèse de Paris, 1926. 17. Labbé, M., and Réchad: Les troubles de la sécretion externe du pancreas dans le diabète sucré , Arch. d. mal. d. l'app. digestif 16:865, 1926. 18. Deusch and Drost: Klin. Wchnschr. 6:2180, 1927. 19. Deusch and Drost: Klin. Wchnschr. 6:2180, 1927. 20. Deusch, G., and Drost, E.: Innere und äussere Sekretion des Pankreas , Klin. Wchnschr. 6:2180, 1927. 21. Kusnetzow, N. W., and Michailowa, S. J.: Die Sekretionstätigkeit der Bauchspeicheldrüse im Verlaufe von Erkrankungen der Gigestionsorgane , Arch. f. Verdauungskr. 40:41, 1927. 22. Okada, S.; Sakurai, E.; Imazu, T., and Kuramochi, K.: Pancreatic Function: I. The Quantitative Estimation of the Pancreatic Secretion , Arch. Int. Med. 42:270 ( (Aug.) ) 1928. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Internal Medicine American Medical Association

PANCREATIC FUNCTION: II. THE PANCREATIC ACTIVITY IN DIABETES MELLITUS

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Publisher
American Medical Association
Copyright
Copyright © 1928 American Medical Association. All Rights Reserved.
ISSN
0730-188X
DOI
10.1001/archinte.1928.00130210108010
Publisher site
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Abstract

Abstract In 1788, Cawley1 reported an intimate relationship between the sugar-regulating function and the pancreas and considered pancreatic disease an important factor in the etiology of diabetes. This was confirmed by various workers, such as Bright, Bouchardat, Friedreich, Bamberger, Frerichs, Senator, Seegen and others. The reports, however, were not more than statistical statements until Lancéraux (1877), on the basis of many clinical and anatomic observations, described a special form of diabetes called diabète pancréatique or diabète maigre. This form is characterized by a sudden onset, a malignant course and a special tendency to the complication of tuberculosis. The epoch-making discovery of von Mering and Minkowski2 in 1889, as well as the independent observations of N. de Dominicis,3 that complete extirpation of the pancreas in dogs always caused pronounced glycosuria, had made a marked effect on the development of the investigation of diabetes. Following the suggestion of Lancéraux, Bouchard and Gilbert in References 1. Labbé and Réchard: Les troubles de la sécrétion externe du pancréas dans le diabète sucré , Arch. d. mal. d. l'app. digestif 16:867, 1926. 2. Von Mering, J., and Minkowski, O.: Diabetes nach Pankreasexstirpation , Zentralbl. f. klin. Med. , 1889, p. 393 3. Arch. f. exper. Path. u. Pharmakol. 26:371, 1889. 4. De Dominicis: Studiisperim. intorno agli effeti delle estirpazione del pancreas , Gior. int. delle sc. med. , 1889, p. 801. 5. Opie, E. T.: Diabetes Mellitus Associated with Hyaline Degeneration of the Islands of Langerhans of the Pancreas , Bull. Johns Hopkins Hosp. 12:263, 1901. 6. Weichselbaum, A., and Stangl, E.: Zur Kenntnis der feineren Veränderungen des Pankreas bei Diabetes Mellitus , Wien. klin. Wchnschr. 14:968, 1901. 7. Banting, F. G., and Best, C. H.: The Internal Secretion of the Pancreas , J. Lab. & Clin. Med. 7:251 ( (Feb.) ) 1922. 8. Macleod, J. J. R.: The Source of Insulin , J. Metab. Research 2:149, 1922. 9. Allen, F. M.: The Pathology of Diabetes , J. Metab. Research 1:165, 1922. 10. Joslin, E. P.: The Treatment of Diabetes Mellitus , ed. 3, Philadelphia, Lea & Febiger, 1923, p. 137. 11. Okada, S.: Ueber die Pankreassekretion bei Sekretionsstörungen des Magens , Mitt. d. med. Fak. d. Kaiserl. Univ. z. Tokyo 13:157, 1914. 12. Von Noorden: Die Zuckerkrankheit , ed. 7, 1915. 13. Katsch, G., and Friedrich, L. v.: Bauchspeichelfluss auf Aetherreiz , Klin. Wchnschr. 1:112, 1922. 14. Langanke, E.: Untersuchungen über die Fermente des Pankreas vor und nach Injektion von Aether ins Duodenum , Klin. Wchnschr. 1:1458, 1922. 15. Jones, C. M.; Castle, W. B.; Mulholland, H. B., and Bailey, F.: Pancreatic and Hepatic Activity in Diabetes Mellitus , Arch. Int. Med. 35:315 ( (March) ) 1925. 16. Bargy, R.: Insuffisance pancreatique externe chez les diabetiques, étudiée par l'evaluation de l'activité fermentaire dans le liquide duodenal , Thèse de Paris, 1926. 17. Labbé, M., and Réchad: Les troubles de la sécretion externe du pancreas dans le diabète sucré , Arch. d. mal. d. l'app. digestif 16:865, 1926. 18. Deusch and Drost: Klin. Wchnschr. 6:2180, 1927. 19. Deusch and Drost: Klin. Wchnschr. 6:2180, 1927. 20. Deusch, G., and Drost, E.: Innere und äussere Sekretion des Pankreas , Klin. Wchnschr. 6:2180, 1927. 21. Kusnetzow, N. W., and Michailowa, S. J.: Die Sekretionstätigkeit der Bauchspeicheldrüse im Verlaufe von Erkrankungen der Gigestionsorgane , Arch. f. Verdauungskr. 40:41, 1927. 22. Okada, S.; Sakurai, E.; Imazu, T., and Kuramochi, K.: Pancreatic Function: I. The Quantitative Estimation of the Pancreatic Secretion , Arch. Int. Med. 42:270 ( (Aug.) ) 1928.

Journal

Archives of Internal MedicineAmerican Medical Association

Published: Oct 1, 1928

References