Abstract Metastatic carcinoma to the optic nerve has infrequently been reported in the ophthalmic literature.1-8 In most of the cases, the nerve has become secondarily involved by extension of tumor from metastatic lesions in adjacent choroid or meninges. However, isolated metastasis to the optic nerve does occur. Carcinoma of the breast accounts for 60% to 70% of ocular metastases, an incidence higher than the relative prevalence of breast carcinoma among malignant tumors. Although metastases from this tumor are most common in the choroid and are found far less frequently in the optic nerve, breast carcinoma accounts for most of the optic nerve lesions which have been reported. Primary tumors of the lung are next in frequency with sporadic cases from other primary sites. Two cases of pancreatic carcinoma were described by Sniderman.8 In both instances, the optic nerve involvement was secondary to extensive metastases in the orbit. This is References 1. Duke-Elder, S.: Diseases of the Inner Eye , St. Louis: C. V. Mosby Co., vol 3, pp 3098-3100. 2. Reese, A.B.: Tumors of the Eye , New York: Paul B. Hoeber, Inc., 1951, pp 496-497. 3. McDannald, C.E., and Payne, B.F.: Metastatic Carcinoma of the Optic Nerve and Choroid , Arch Ophthal 12:86-92, 1934.Crossref 4. Elschnig, A.: The Metastatic Tumors of the Eye , Arch Ophthal 20:370-379, 1891. 5. Nicholls, J.U.V.: Metastatic Carcinoma of the Optic Nerve , Trans Canada Ophthal Soc 24:18-30, 1961. 6. Weigenblatt, S.: Metastatic Disease of the Optic Nerve , Amer J Ophthal 47:77-83, 1959. 7. Davis, W.: Metastatic Carcinoma of the Optic Disc , Arch Ophthal 8:226-237, 1932.Crossref 8. Sniderman, H.R.: Orbital Metastases From Tumor of the Pancreas , Amer J Ophthal 25:1215-1221, 1942. 9. Stout, A.P.: Human Cancer , Philadelphia: Lea & Febiger, 1932, p 172.
Archives of Ophthalmology – American Medical Association
Published: Jun 1, 1967