Objective: To determine whether perioperative transfusion of leukocyte-depleted blood is a predictor of recurrence and survival in patients with head and neck cancer. Design: Retrospective case series. Setting: Tertiary referral teaching center. Patients: Patients undergoing head and neck surgery for malignant disease between October 1996 and October 2002. Intervention: Demographic and clinical information was obtained from hospital, blood bank, and cancer registry databases and recorded onto a standardized computer spreadsheet. Main Outcome Measures: The primary outcome variable was the number of units of allogeneic leukocyte-depleted blood transfused perioperatively. Multivariate analysis and logistic regression methods were used to determine whether significant associations existed between perioperative transfusion and second primary cancers, recurrence, and survival. Results: Six hundred forty-seven patients met the criteria for inclusion in the study. Analysis showed significant associations between perioperative transfusion, recurrence, and survival. Conclusion: Perioperative transfusion of leukocyte-depleted blood is associated with higher recurrence rates and decreased survival in patients with head and neck cancer.
Archives of Otolaryngology - Head & Neck Surgery – American Medical Association
Published: Aug 1, 2006
Keywords: head and neck cancer,surgical procedures, operative,surgery specialty,transfusion
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