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P164 Extrathyroidal Extension in Well-Differentiated Thyroid Cancer as a Predictor of Outcome Measures

P164 Extrathyroidal Extension in Well-Differentiated Thyroid Cancer as a Predictor of Outcome... Objectives: To examine the prognostic difference between gross and microscopic extrathyroidal extension (ETE) in well-differentiated thyroid cancer (WDTC). Design: Retrospective study. Setting: Tertiary care academic hospital. Patients: From a database of 582 patients who were surgically treated for thyroid cancer, we selected 55 (10.5%) with stage III WDTC and a minimum 5-year follow-up (17 men and 38 women; mean age, 53.1 years). Main Outcome Measures: Overall survival (OS) and disease-specific survival (DSS) at 5, 10, and 20 years and recurrence rates. Results: In univariate analysis, there was no difference in 5, 10, and 20-year OS, 5, 10, and 20-year DSS, and recurrence rates in the gross vs microscopic groups (P = .59, P = .39, P = .58, P = .45, P = .37, P = .62, and P = .37, respectively). The only confounding factor was that more patients were treated with external-beam radiation therapy (RT) in the gross than in the microscopic ETE group (P = .007). In multivariable analysis, RT, and not gross vs microscopic ETE, trended toward being a predictor of OS and DSS. In Kaplan-Meier curve analysis, gross vs microscopic ETE had no effect on OS or DSS in the RT group. In the no-RT group, gross ETE had a strong trend toward decreased OS and DSS. Conclusions: Gross vs microscopic ETE does not alter OS and DSS when the patient has received RT; however, gross ETE has a strong trend toward decreased OS and DSS when the patient has not received RT. In patients with gross ETE, we would recommend RT. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Otolaryngology - Head & Neck Surgery American Medical Association

P164 Extrathyroidal Extension in Well-Differentiated Thyroid Cancer as a Predictor of Outcome Measures

P164 Extrathyroidal Extension in Well-Differentiated Thyroid Cancer as a Predictor of Outcome Measures

Abstract

Objectives: To examine the prognostic difference between gross and microscopic extrathyroidal extension (ETE) in well-differentiated thyroid cancer (WDTC). Design: Retrospective study. Setting: Tertiary care academic hospital. Patients: From a database of 582 patients who were surgically treated for thyroid cancer, we selected 55 (10.5%) with stage III WDTC and a minimum 5-year follow-up (17 men and 38 women; mean age, 53.1 years). Main Outcome Measures: Overall survival (OS) and...
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Publisher
American Medical Association
Copyright
Copyright © 2006 American Medical Association. All Rights Reserved.
ISSN
0886-4470
eISSN
1538-361X
DOI
10.1001/archotol.132.8.897-b
Publisher site
See Article on Publisher Site

Abstract

Objectives: To examine the prognostic difference between gross and microscopic extrathyroidal extension (ETE) in well-differentiated thyroid cancer (WDTC). Design: Retrospective study. Setting: Tertiary care academic hospital. Patients: From a database of 582 patients who were surgically treated for thyroid cancer, we selected 55 (10.5%) with stage III WDTC and a minimum 5-year follow-up (17 men and 38 women; mean age, 53.1 years). Main Outcome Measures: Overall survival (OS) and disease-specific survival (DSS) at 5, 10, and 20 years and recurrence rates. Results: In univariate analysis, there was no difference in 5, 10, and 20-year OS, 5, 10, and 20-year DSS, and recurrence rates in the gross vs microscopic groups (P = .59, P = .39, P = .58, P = .45, P = .37, P = .62, and P = .37, respectively). The only confounding factor was that more patients were treated with external-beam radiation therapy (RT) in the gross than in the microscopic ETE group (P = .007). In multivariable analysis, RT, and not gross vs microscopic ETE, trended toward being a predictor of OS and DSS. In Kaplan-Meier curve analysis, gross vs microscopic ETE had no effect on OS or DSS in the RT group. In the no-RT group, gross ETE had a strong trend toward decreased OS and DSS. Conclusions: Gross vs microscopic ETE does not alter OS and DSS when the patient has received RT; however, gross ETE has a strong trend toward decreased OS and DSS when the patient has not received RT. In patients with gross ETE, we would recommend RT.

Journal

Archives of Otolaryngology - Head & Neck SurgeryAmerican Medical Association

Published: Aug 1, 2006

Keywords: well-differentiated thyroid carcinoma,outcome measures

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