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Oxytetracycline Intramuscular in the Treatment of Early Syphilis

Oxytetracycline Intramuscular in the Treatment of Early Syphilis Abstract Although the incidence of syphilis has been declining, this disease has by no means been eradicated, and it always maintains the potential of rising to former heights. It is therefore imperative that we continue our interest in its therapy. This report concerns the effectiveness of oxytetracycline* intramuscular in early syphilis. This form of the drug has not been previously investigated in syphilotherapy; it has, however, been used with good results in the treatment of the treponematosis, yaws, as reported by Loughlin and his associates.1 Both oral and intravenous forms of the wide-spectrum antibiotics have now been employed in the treatment of syphilis. However, prior to this present report chloramphenicol was the only one of this class of antibiotics that had been utilized by the intramuscular route. Intramuscular administration of a drug has certain definite advantages. In dealing with an infectious disease such as syphilis, it References 1. The trade name of Chas. Pfizer & Company for oxytetracycline is Terramycin. The oxytetracycline intramuscular used in this study was supplied through the courtesy of Drs. Elliott R. Weyer and Michael Carlozzi of Chas. Pfizer & Company, Inc., Brooklyn. 2. References 2 to 5. 3. References 8, 10, 11, and 12. 4. References 8 and 14. 5. References 7, 9, and 15. 6. References 8 and 14. 7. Loughlin, E. H.; Joseph, A. A., and Duvalier, F.: Oxytetracycline Intramuscular in the Treatment of Yaws (Pian) , Antibiotics & Chemother. 4:155-164, 1954. 8. Waldbott, G. L.: Anaphylatic Death From Penicillin , J. A. M. A. 139:526-527, 1949. 9. Higgins, G. A., and Rothchild, T. P. E.: Fatal Anaphylatic Shock from Procaine Penicillin , New England J. Med. 247:644-646, 1952. 10. Kern, R. A., and Wimberley, N. A., Jr.: Penicillin Reactions: Their Nature, Growing Importance, Recognition, Management and Prevention , Am. J. M. Sc. 226:357-375, 1953. 11. Rosenthal, A.: Eight Fatal Anaphylatic Reactions to Penicillin , New York J. Med. 54:1485-1487, 1954. 12. Finland, M.; Grigsby, M. E., and Haight, T. H.: Efficacy and Toxicity of Oxytetracycline (Terramycin) and Chlortetracycline (Aureomycin): With Special Reference to Use of Doses of 250 mg. Every Four to Six Hours and to Occurrence of Staphylococcic Diarrhea , A. M. A. Arch. Int. Med. 93:23-43, 1954. 13. Hendricks, F. D.; Greaves, A. B.; Olansky, S.; Taggart, S. R.; Lewis, C. N., Landman, G. S.; MacDonald, G. R., and Welsh, H.: Terramycin in the Treatment of Venereal Disease , J. A. M. A. 143:4-5, 1950. 14. Robinson, H. M., and Robinson, H. M., Jr.: Antibiotics in Early Syphilis and in Syphilis Complicated by Pregnancy , A. M. A. Arch. Dermat. & Syph. 63:687-701, 1951. 15. Irgang, S., and Alexander, E. R.: Treatment of Early Syphilis with Terramycin: Report Based on a Study of 10 Cases , Am. J. Syph. 37:247-252, 1953. 16. Dunlop, E. M. C., and Robinson, R. C. V.: Intravenous Terramycin in the Treatment of Early Syphilis and Granuloma Inguinale , Am. J. Syph. 38:24-29, 1954. 17. Rodriquez, J.; Plotke, F.; Weinstein, S., and Harris, W. W.: Aureomycin and Its Effect in Early Syphilis , A. M. A. Arch. Dermat. & Syph. 63:433-439, 1951. 18. Olansky, S.; Harb, F. W.; Wood, C. E., and Rambo, D. S.: Intramuscular Chloromycetin (Chloramphenicol) in the Treatment of Venereal Disease , Am. J. Syph. 37:253-258, 1953. 19. Moore, J. E.; Mahoney, J. F.; Schwartz, W.; Sternberg, T., and Wood, W. B.: The Treatment of Early Syphilis with Penicillin , J. A. M. A. 126:67-73, 1944. 20. Robinson, H. M., and Robinson, H. M., Jr.: Broad Spectrum Antibiotic Therapy of Early Syphilis: Posttreatment Survey , Am. J. Syph. 37:243-252, 1953. 21. Schoch, A. G., and Alexander, L. J.: Terramycin in the Control of Venereal Diseases , Ann. New York Acad. Sc. 53:459-460, 1950. 22. Rodriquez, J.; Weinstein, S., and Parkhurst, G. E.: Aureomycin and Its Effect in Early Syphilis , A. M. A. Arch. Dermat. & Syph. 66:59-64, 1952. 23. Lewis, C. N.; Putnam, L. E.; Hendricks, F. D.; Kerlan, I., and Welsh, H.: Choramphenicol (Chloromycetin) in Relation to Blood Dycrasias with Observations on Other Drugs: Special Survey , Antibiotics & Chemother. 2:601-609, 1952. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png A.M.A. Archives of Dermatology American Medical Association

Oxytetracycline Intramuscular in the Treatment of Early Syphilis

A.M.A. Archives of Dermatology , Volume 73 (5) – May 1, 1956

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Publisher
American Medical Association
Copyright
Copyright © 1956 American Medical Association. All Rights Reserved.
ISSN
0096-5359
DOI
10.1001/archderm.1956.01550050067012
Publisher site
See Article on Publisher Site

Abstract

Abstract Although the incidence of syphilis has been declining, this disease has by no means been eradicated, and it always maintains the potential of rising to former heights. It is therefore imperative that we continue our interest in its therapy. This report concerns the effectiveness of oxytetracycline* intramuscular in early syphilis. This form of the drug has not been previously investigated in syphilotherapy; it has, however, been used with good results in the treatment of the treponematosis, yaws, as reported by Loughlin and his associates.1 Both oral and intravenous forms of the wide-spectrum antibiotics have now been employed in the treatment of syphilis. However, prior to this present report chloramphenicol was the only one of this class of antibiotics that had been utilized by the intramuscular route. Intramuscular administration of a drug has certain definite advantages. In dealing with an infectious disease such as syphilis, it References 1. The trade name of Chas. Pfizer & Company for oxytetracycline is Terramycin. The oxytetracycline intramuscular used in this study was supplied through the courtesy of Drs. Elliott R. Weyer and Michael Carlozzi of Chas. Pfizer & Company, Inc., Brooklyn. 2. References 2 to 5. 3. References 8, 10, 11, and 12. 4. References 8 and 14. 5. References 7, 9, and 15. 6. References 8 and 14. 7. Loughlin, E. H.; Joseph, A. A., and Duvalier, F.: Oxytetracycline Intramuscular in the Treatment of Yaws (Pian) , Antibiotics & Chemother. 4:155-164, 1954. 8. Waldbott, G. L.: Anaphylatic Death From Penicillin , J. A. M. A. 139:526-527, 1949. 9. Higgins, G. A., and Rothchild, T. P. E.: Fatal Anaphylatic Shock from Procaine Penicillin , New England J. Med. 247:644-646, 1952. 10. Kern, R. A., and Wimberley, N. A., Jr.: Penicillin Reactions: Their Nature, Growing Importance, Recognition, Management and Prevention , Am. J. M. Sc. 226:357-375, 1953. 11. Rosenthal, A.: Eight Fatal Anaphylatic Reactions to Penicillin , New York J. Med. 54:1485-1487, 1954. 12. Finland, M.; Grigsby, M. E., and Haight, T. H.: Efficacy and Toxicity of Oxytetracycline (Terramycin) and Chlortetracycline (Aureomycin): With Special Reference to Use of Doses of 250 mg. Every Four to Six Hours and to Occurrence of Staphylococcic Diarrhea , A. M. A. Arch. Int. Med. 93:23-43, 1954. 13. Hendricks, F. D.; Greaves, A. B.; Olansky, S.; Taggart, S. R.; Lewis, C. N., Landman, G. S.; MacDonald, G. R., and Welsh, H.: Terramycin in the Treatment of Venereal Disease , J. A. M. A. 143:4-5, 1950. 14. Robinson, H. M., and Robinson, H. M., Jr.: Antibiotics in Early Syphilis and in Syphilis Complicated by Pregnancy , A. M. A. Arch. Dermat. & Syph. 63:687-701, 1951. 15. Irgang, S., and Alexander, E. R.: Treatment of Early Syphilis with Terramycin: Report Based on a Study of 10 Cases , Am. J. Syph. 37:247-252, 1953. 16. Dunlop, E. M. C., and Robinson, R. C. V.: Intravenous Terramycin in the Treatment of Early Syphilis and Granuloma Inguinale , Am. J. Syph. 38:24-29, 1954. 17. Rodriquez, J.; Plotke, F.; Weinstein, S., and Harris, W. W.: Aureomycin and Its Effect in Early Syphilis , A. M. A. Arch. Dermat. & Syph. 63:433-439, 1951. 18. Olansky, S.; Harb, F. W.; Wood, C. E., and Rambo, D. S.: Intramuscular Chloromycetin (Chloramphenicol) in the Treatment of Venereal Disease , Am. J. Syph. 37:253-258, 1953. 19. Moore, J. E.; Mahoney, J. F.; Schwartz, W.; Sternberg, T., and Wood, W. B.: The Treatment of Early Syphilis with Penicillin , J. A. M. A. 126:67-73, 1944. 20. Robinson, H. M., and Robinson, H. M., Jr.: Broad Spectrum Antibiotic Therapy of Early Syphilis: Posttreatment Survey , Am. J. Syph. 37:243-252, 1953. 21. Schoch, A. G., and Alexander, L. J.: Terramycin in the Control of Venereal Diseases , Ann. New York Acad. Sc. 53:459-460, 1950. 22. Rodriquez, J.; Weinstein, S., and Parkhurst, G. E.: Aureomycin and Its Effect in Early Syphilis , A. M. A. Arch. Dermat. & Syph. 66:59-64, 1952. 23. Lewis, C. N.; Putnam, L. E.; Hendricks, F. D.; Kerlan, I., and Welsh, H.: Choramphenicol (Chloromycetin) in Relation to Blood Dycrasias with Observations on Other Drugs: Special Survey , Antibiotics & Chemother. 2:601-609, 1952.

Journal

A.M.A. Archives of DermatologyAmerican Medical Association

Published: May 1, 1956

References