Abstract THIS IS a rare benign tumor of the salivary glands described in the literature under different names: oncocytoma, adenoma, pyknocytoma, oxyphilic adenoma, acidophilic adenoma, oxyphilic cell adenoma, etc. The terminology is still more confused as evidenced in recent publications which consider histologically different tumors of the parotid gland to be identical and use their names interchangeably: papillary cystadenoma lymphomatosum or Warthin's tumor, adenolymphoma, oxyphilic granular-cell tumors and benign lymphoepithelial lesions or Mikulicz's disease, this due to the fact that these lesions contain oncocytes in different amounts.1 The oxyphilic granular-cell adenoma is a tumor formed by cells called oncocytes, this designation used for the first time by Hamperl2 who derived it from the Greek word Ογκονζ θαι meaning "increase in bulk." He credits Schaffer with first describing these cells as "granular swollen cells," and later Zimmerman called them pyknocytes. It is considered that the first such tumor described in References 1. Eneroth, C.M.: Oncocytoma of the Major Salivary Glands , J Laryng 79:1064-1072, 1965.Crossref 2. Hamperl, H.: Beiträge Zur normalen und pathologischen Histologie menschlicher Speicheldrüsen , Z Mikr Anat Forsch 27:1-55, 1931. 3. Duplay, M.: Adénome de la glande sousmaxillaire , Arch Gén Med 1:601-603, 1875. 4. Christopherson, W.M.: Oncocytoma of the Parotid Gland , Arch Path 48:96-98, 1949. 5. Foote, F.W., Jr., and Frazell, E.L.: Tumors of the Major Salivary Glands , Cancer 6:1065-1133, 1953.Crossref 6. Trier, J.S.: Fine Structure of Parathyroid Gland , J Biophys Biochem 4:13-22, 1958.Crossref 7. Hamperl, H.: Z Krebsforsch 64:127, 1962 8. (cited by Eneroth, C.M.).1 9. Meza-Chávez, L.: Oxyphilic Granular-Cell Adenoma of the Parotid Gland (Oncocytoma): Report of Five Cases and Study of Oxyphilic Granular-Cell (Oncocytes) in Normal Parotid Glands , Amer J Path 25:523-538, 1949. 10. Bauer, W.H., and Bauer, J.D.: Classification of Glandular Tumors of Salivary Glands: Study of 143 Cases , Arch Path 55:328-346, 1953. 11. Hamperl, H.: Benign and Malignant Oncocytoma , Cancer 15:1019-1027, 1962.Crossref
Archives of Otolaryngology – American Medical Association
Published: May 1, 1968
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