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OXYPHENONIUM (ANTRENYL): A Potent Atropine Substitute

OXYPHENONIUM (ANTRENYL): A Potent Atropine Substitute Abstract OXYPHENONIUM (Antrenyl), a synthetic quaternary ammonium salt (diethyl [2-hydroxyethyl] methylammonium bromide α-phenylcyclohexaneglycolate), is a powerful mydriatic and cycloplegic drug. Its anticholinergic pharmacologic effects are essentially the same as those of atropine and are obtainable with approximately the same concentration of drug.1 Oxyphenonium is stable in tablet or solution and may be administered topically, orally, or parenterally. It is freely soluble in water and almost completely insoluble in nonpolar solvents. Oxyphenonium has been used clinically in the therapy of peptic ulcer and allied digestive disorders2 and as a preanesthetic medication. LABORATORY EVALUATION OF OXYPHENONIUM Excellent mydriasis, persisting for four to eight days, is produced in adult albino rabbits by a single ocular instillation of one drop of 5% oxyphenonium bromide in 1: 5,000 benzalkonium (Zephiran) chloride. This mydriasis is complete within an hour. A 1% oxyphenonium solution produces complete mydriasis for two days, with return to normal by the References 1. Hurwitz, Paul: Personal communication to the authors. 2. Plummer, A. J.; Barrett, W. E.; Rutledge, R., and Yonkman, F. F.: Pharmacologic Properties of Ba-5473, Phenylcyclohexyl Oxyacetic Acid Ester of Diethylaminomethyl Bromide, to be published; available as reprint from Ciba Pharmaceutical Products, Inc., Summit, N. J. 3. Rogers, M. P., and Gray, C. L.: A New Anti-Ulcer Drug , Am. J. Digest. Dis. 19:180-185 ( (June) ) 1952.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png A.M.A. Archives of Ophthalmology American Medical Association

OXYPHENONIUM (ANTRENYL): A Potent Atropine Substitute

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Publisher
American Medical Association
Copyright
Copyright © 1954 American Medical Association. All Rights Reserved.
ISSN
0096-6339
DOI
10.1001/archopht.1954.00920050517002
Publisher site
See Article on Publisher Site

Abstract

Abstract OXYPHENONIUM (Antrenyl), a synthetic quaternary ammonium salt (diethyl [2-hydroxyethyl] methylammonium bromide α-phenylcyclohexaneglycolate), is a powerful mydriatic and cycloplegic drug. Its anticholinergic pharmacologic effects are essentially the same as those of atropine and are obtainable with approximately the same concentration of drug.1 Oxyphenonium is stable in tablet or solution and may be administered topically, orally, or parenterally. It is freely soluble in water and almost completely insoluble in nonpolar solvents. Oxyphenonium has been used clinically in the therapy of peptic ulcer and allied digestive disorders2 and as a preanesthetic medication. LABORATORY EVALUATION OF OXYPHENONIUM Excellent mydriasis, persisting for four to eight days, is produced in adult albino rabbits by a single ocular instillation of one drop of 5% oxyphenonium bromide in 1: 5,000 benzalkonium (Zephiran) chloride. This mydriasis is complete within an hour. A 1% oxyphenonium solution produces complete mydriasis for two days, with return to normal by the References 1. Hurwitz, Paul: Personal communication to the authors. 2. Plummer, A. J.; Barrett, W. E.; Rutledge, R., and Yonkman, F. F.: Pharmacologic Properties of Ba-5473, Phenylcyclohexyl Oxyacetic Acid Ester of Diethylaminomethyl Bromide, to be published; available as reprint from Ciba Pharmaceutical Products, Inc., Summit, N. J. 3. Rogers, M. P., and Gray, C. L.: A New Anti-Ulcer Drug , Am. J. Digest. Dis. 19:180-185 ( (June) ) 1952.Crossref

Journal

A.M.A. Archives of OphthalmologyAmerican Medical Association

Published: Oct 1, 1954

References