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Overexpression of p53 in Disseminated Superficial Actinic Porokeratosis With and Without Malignant Degeneration

Overexpression of p53 in Disseminated Superficial Actinic Porokeratosis With and Without... Abstract We have read with interest the recent article by Magee et al1 regarding overexpression of p53 in the nuclei of (mainly basal) keratinocytes within or under the lamella cornoides (cornoid lamella) in the lesions of porokeratosis. The findings of Magee et al1 support the premalignant potential of porokeratosis lesions but are in contrast with the pattern of expression of p53 in Bowen's disease, in which intense staining is present in the middle and upper spinous layers, similar to that seen in solar keratosis. Malignant degeneration has been observed in up to 10% of cases of porokeratosis, the most common types of lesions reported being in situ or invasive squamous cell carcinomas, Bowen's disease, and, rarely, basal cell carcinomas. We have attempted to confirm the results obtained by Magee et al using a different monoclonal antibody to assess p53 expression in keratinocytes from disseminated superficial actinic porokeratosis (DSAP) lesions and References 1. Magee JW, McCalmont TH, LeBoit PE. Overexpression of p53 tumor suppressor protein in porokeratosis . Arch Dermatol. 1994;130:187-190.Crossref 2. Campbell C, Quinn AG, Angus B, Rees JL. The relation between p53 mutation and p53 immunostaining in non-melanoma skin cancer . Br J Dermatol. 1993;129:235-241.Crossref 3. McNutt NS, Saenz de Santamaria C, Volkenandt M, Shea CR, Albino AP. Abnormalities of p53 protein expression in cutaneous disorders . Arch Dermatol. 1994;130:225-232.Crossref 4. Kubo Y, Urano Y, Yoshimoto K, et al. p53 Gene mutations in human skin cancers and precancerous lesions: comparison with immunohistochemical analysis . J Invest Dermatol. 1994;102:440-444.Crossref 5. Lu X, Lane DP. Differential induction of transcriptionally active p53 following UV or ionizing radiation: defects in chromosome instability syndromes? Cell. 1993;75:765-778.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology American Medical Association

Overexpression of p53 in Disseminated Superficial Actinic Porokeratosis With and Without Malignant Degeneration

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Publisher
American Medical Association
Copyright
Copyright © 1995 American Medical Association. All Rights Reserved.
ISSN
0003-987X
eISSN
1538-3652
DOI
10.1001/archderm.1995.01690150119025
Publisher site
See Article on Publisher Site

Abstract

Abstract We have read with interest the recent article by Magee et al1 regarding overexpression of p53 in the nuclei of (mainly basal) keratinocytes within or under the lamella cornoides (cornoid lamella) in the lesions of porokeratosis. The findings of Magee et al1 support the premalignant potential of porokeratosis lesions but are in contrast with the pattern of expression of p53 in Bowen's disease, in which intense staining is present in the middle and upper spinous layers, similar to that seen in solar keratosis. Malignant degeneration has been observed in up to 10% of cases of porokeratosis, the most common types of lesions reported being in situ or invasive squamous cell carcinomas, Bowen's disease, and, rarely, basal cell carcinomas. We have attempted to confirm the results obtained by Magee et al using a different monoclonal antibody to assess p53 expression in keratinocytes from disseminated superficial actinic porokeratosis (DSAP) lesions and References 1. Magee JW, McCalmont TH, LeBoit PE. Overexpression of p53 tumor suppressor protein in porokeratosis . Arch Dermatol. 1994;130:187-190.Crossref 2. Campbell C, Quinn AG, Angus B, Rees JL. The relation between p53 mutation and p53 immunostaining in non-melanoma skin cancer . Br J Dermatol. 1993;129:235-241.Crossref 3. McNutt NS, Saenz de Santamaria C, Volkenandt M, Shea CR, Albino AP. Abnormalities of p53 protein expression in cutaneous disorders . Arch Dermatol. 1994;130:225-232.Crossref 4. Kubo Y, Urano Y, Yoshimoto K, et al. p53 Gene mutations in human skin cancers and precancerous lesions: comparison with immunohistochemical analysis . J Invest Dermatol. 1994;102:440-444.Crossref 5. Lu X, Lane DP. Differential induction of transcriptionally active p53 following UV or ionizing radiation: defects in chromosome instability syndromes? Cell. 1993;75:765-778.Crossref

Journal

Archives of DermatologyAmerican Medical Association

Published: Mar 1, 1995

References