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Outcomes of Mild Cognitive Impairment by Definition

Outcomes of Mild Cognitive Impairment by Definition ORIGINAL CONTRIBUTION A Population Study Mary Ganguli, MD, MPH; Beth E. Snitz, PhD; Judith A. Saxton, PhD; Chung-Chou H. Chang, PhD; Ching-Wen Lee, MS; Joni Vander Bilt, MPH; Tiffany F. Hughes, PhD; David A. Loewenstein, PhD; Frederick W. Unverzagt, PhD; Ronald C. Petersen, PhD, MD Background: Mild cognitive impairment (MCI) has been Results: Regardless of MCI definition, over 1 year, a small defined in several ways. proportion of participants progressed to CDR1 (range, 0%-3%) or severe cognitive impairment (0%-20%) at rates Objective: To determine the 1-year outcomes of MCI higher than their cognitively normal peers. Somewhat larger by different definitions at the population level. proportions of participants improved or reverted to nor- mal (6%-53%). Most participants remained stable (29%- Design: Inception cohort with 1-year follow-up. Par- 92%). Where definitions focused on memory impairment ticipants were classified as having MCI using the follow- and on multiple cognitive domains, higher proportions pro- ing definitions operationalized for this study: amnestic gressed and lower proportions reverted on the CDR. MCI by Mayo criteria, expanded MCI by International Working Group criteria, Clinical Dementia Rating (CDR) Conclusions: As ascertained by several operational defi- =0.5, and a purely cognitive classification into amnestic nitions, MCI is a http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA Neurology American Medical Association

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Publisher
American Medical Association
Copyright
Copyright 2011 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
2168-6149
eISSN
2168-6157
DOI
10.1001/archneurol.2011.101
pmid
21670400
Publisher site
See Article on Publisher Site

Abstract

ORIGINAL CONTRIBUTION A Population Study Mary Ganguli, MD, MPH; Beth E. Snitz, PhD; Judith A. Saxton, PhD; Chung-Chou H. Chang, PhD; Ching-Wen Lee, MS; Joni Vander Bilt, MPH; Tiffany F. Hughes, PhD; David A. Loewenstein, PhD; Frederick W. Unverzagt, PhD; Ronald C. Petersen, PhD, MD Background: Mild cognitive impairment (MCI) has been Results: Regardless of MCI definition, over 1 year, a small defined in several ways. proportion of participants progressed to CDR1 (range, 0%-3%) or severe cognitive impairment (0%-20%) at rates Objective: To determine the 1-year outcomes of MCI higher than their cognitively normal peers. Somewhat larger by different definitions at the population level. proportions of participants improved or reverted to nor- mal (6%-53%). Most participants remained stable (29%- Design: Inception cohort with 1-year follow-up. Par- 92%). Where definitions focused on memory impairment ticipants were classified as having MCI using the follow- and on multiple cognitive domains, higher proportions pro- ing definitions operationalized for this study: amnestic gressed and lower proportions reverted on the CDR. MCI by Mayo criteria, expanded MCI by International Working Group criteria, Clinical Dementia Rating (CDR) Conclusions: As ascertained by several operational defi- =0.5, and a purely cognitive classification into amnestic nitions, MCI is a

Journal

JAMA NeurologyAmerican Medical Association

Published: Jun 1, 2011

References

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