ORIGINAL CONTRIBUTION A Population Study Mary Ganguli, MD, MPH; Beth E. Snitz, PhD; Judith A. Saxton, PhD; Chung-Chou H. Chang, PhD; Ching-Wen Lee, MS; Joni Vander Bilt, MPH; Tiffany F. Hughes, PhD; David A. Loewenstein, PhD; Frederick W. Unverzagt, PhD; Ronald C. Petersen, PhD, MD Background: Mild cognitive impairment (MCI) has been Results: Regardless of MCI definition, over 1 year, a small defined in several ways. proportion of participants progressed to CDR1 (range, 0%-3%) or severe cognitive impairment (0%-20%) at rates Objective: To determine the 1-year outcomes of MCI higher than their cognitively normal peers. Somewhat larger by different definitions at the population level. proportions of participants improved or reverted to nor- mal (6%-53%). Most participants remained stable (29%- Design: Inception cohort with 1-year follow-up. Par- 92%). Where definitions focused on memory impairment ticipants were classified as having MCI using the follow- and on multiple cognitive domains, higher proportions pro- ing definitions operationalized for this study: amnestic gressed and lower proportions reverted on the CDR. MCI by Mayo criteria, expanded MCI by International Working Group criteria, Clinical Dementia Rating (CDR) Conclusions: As ascertained by several operational defi- =0.5, and a purely cognitive classification into amnestic nitions, MCI is a
JAMA Neurology – American Medical Association
Published: Jun 1, 2011
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.
All for just $49/month
Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly
Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.
Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.
Read from thousands of the leading scholarly journals from SpringerNature, Wiley-Blackwell, Oxford University Press and more.
All the latest content is available, no embargo periods.
“Hi guys, I cannot tell you how much I love this resource. Incredible. I really believe you've hit the nail on the head with this site in regards to solving the research-purchase issue.”Daniel C.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud
“I must say, @deepdyve is a fabulous solution to the independent researcher's problem of #access to #information.”@deepthiw
“My last article couldn't be possible without the platform @deepdyve that makes journal papers cheaper.”@JoseServera