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Outcome of Hepatitis in Children With Acute Leukemia

Outcome of Hepatitis in Children With Acute Leukemia Abstract • The cases of 31 children with acute leukemia and concurrent hepatitis were evaluated for the outcome of their hepatitis. Thirteen of these children had hepatitis B and 18 children had a non-B hepatitis. Chronic hepatitis developed in more than half of the children with acute hepatitis, with the majority of cases being of the chronic, active type. A majority of these children had received at least one blood transfusion in the preceding year. No relationship was seen between the development of chronicity of the liver disease and the management of the acute hepatitis or the state of underlying disease. With the potential for a cure for acute leukemia increasing, a method of reducing the sequelae of hepatitis in children with leukemia is needed. (Am J Dis Child 134:584-587, 1980) References 1. Blumberg BS, Alter HJ, Visnick S, et al: A new antigen in leukemic sera . JAMA 191:541-546, 1965.Crossref 2. Wands JR, Chura CM, Roll FJ, et al: Serial studies of hepatitis-associated antigen and antibody in patients receiving antitumor chemotherapy for myeloproliferative and lymphoproliferative disorders . Gastroenterology 68:105-112, 1975. 3. Tabor E, Gerety RJ, Mott M, et al: Prevalence of hepatitis B in a high-risk setting: A serologic study of patients and staff in pediatric oncology unit . Pediatrics 61:711-715, 1978. 4. Aur RJ, Simone JV, Verzosa MS, et al: Childhood leukemia: Study VIII . Cancer 42:2123-2134, 1978.Crossref 5. George P, Hernandez K, Hustu O, et al: A study of "total therapy" of acute lymphocytic leukemia in children . J Pediatr 72:399-408, 1968.Crossref 6. Morphological criteria in viral hepatitis . Lancet 1:333-337, 1971. 7. Ludwig J: A review of lobular, portal, and periportal hepatitis . Hum Pathol 8:869-876, 1977.Crossref 8. Conrad ME: Current status of posttransfusion hepatitis . Am J Hematol 1:357-365, 1976.Crossref 9. Lesesne HR, Morgan JE, Blatt PM, et al: Liver biopsy in hemophilia A . Ann Intern Med 86:703-707, 1977.Crossref 10. Einhorn M, Davidsohn I: Hepatotoxicity of mercaptopurine . JAMA 188:802-806, 1964.Crossref 11. McIntosh S, Davidson DL, O'Brien RT, et al: Methotrexate hepatotoxicity in children with leukemia . J Pediatr 90:1019-1021, 1977.Crossref 12. Perman JA, Grand RJ: Acute and chronic hepatitis in children . Postgrad Med J 63:191-200, 1978. 13. Mihas AA, Conrad ME: Hepatitis B antigen and the liver . Medicine 57:129-150, 1978.Crossref 14. Berman M, Alter HJ, Ishak KG, et al: The chronic sequelae of non-A, non-B hepatitis . Ann Intern Med 91:1-6, 1979.Crossref 15. Knodell RG, Conrad ME, Ishak KG: Development of chronic liver disease after acute non-A, non-B posttransfusion hepatitis: Role of γ-globulin prophylaxis in its prevention . Gastroenterology 72:902-909, 1977. 16. Barton JC, Conrad ME: Beneficial effects of hepatitis in patients with acute myelogenous leukemia . Ann Intern Med 90:188-190, 1979.Crossref 17. George SL, Aur RJA, Mauer AM, et al: A reappraisal of the results of stopping therapy in childhood leukemia . N Engl J Med 300:269-273, 1979.Crossref 18. Harris RC, Tabar E: When is hepatitis chronic? J Pediatr 95:551-552, 1979.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Diseases of Children American Medical Association

Outcome of Hepatitis in Children With Acute Leukemia

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Publisher
American Medical Association
Copyright
Copyright © 1980 American Medical Association. All Rights Reserved.
ISSN
0002-922X
DOI
10.1001/archpedi.1980.02130180042013
Publisher site
See Article on Publisher Site

Abstract

Abstract • The cases of 31 children with acute leukemia and concurrent hepatitis were evaluated for the outcome of their hepatitis. Thirteen of these children had hepatitis B and 18 children had a non-B hepatitis. Chronic hepatitis developed in more than half of the children with acute hepatitis, with the majority of cases being of the chronic, active type. A majority of these children had received at least one blood transfusion in the preceding year. No relationship was seen between the development of chronicity of the liver disease and the management of the acute hepatitis or the state of underlying disease. With the potential for a cure for acute leukemia increasing, a method of reducing the sequelae of hepatitis in children with leukemia is needed. (Am J Dis Child 134:584-587, 1980) References 1. Blumberg BS, Alter HJ, Visnick S, et al: A new antigen in leukemic sera . JAMA 191:541-546, 1965.Crossref 2. Wands JR, Chura CM, Roll FJ, et al: Serial studies of hepatitis-associated antigen and antibody in patients receiving antitumor chemotherapy for myeloproliferative and lymphoproliferative disorders . Gastroenterology 68:105-112, 1975. 3. Tabor E, Gerety RJ, Mott M, et al: Prevalence of hepatitis B in a high-risk setting: A serologic study of patients and staff in pediatric oncology unit . Pediatrics 61:711-715, 1978. 4. Aur RJ, Simone JV, Verzosa MS, et al: Childhood leukemia: Study VIII . Cancer 42:2123-2134, 1978.Crossref 5. George P, Hernandez K, Hustu O, et al: A study of "total therapy" of acute lymphocytic leukemia in children . J Pediatr 72:399-408, 1968.Crossref 6. Morphological criteria in viral hepatitis . Lancet 1:333-337, 1971. 7. Ludwig J: A review of lobular, portal, and periportal hepatitis . Hum Pathol 8:869-876, 1977.Crossref 8. Conrad ME: Current status of posttransfusion hepatitis . Am J Hematol 1:357-365, 1976.Crossref 9. Lesesne HR, Morgan JE, Blatt PM, et al: Liver biopsy in hemophilia A . Ann Intern Med 86:703-707, 1977.Crossref 10. Einhorn M, Davidsohn I: Hepatotoxicity of mercaptopurine . JAMA 188:802-806, 1964.Crossref 11. McIntosh S, Davidson DL, O'Brien RT, et al: Methotrexate hepatotoxicity in children with leukemia . J Pediatr 90:1019-1021, 1977.Crossref 12. Perman JA, Grand RJ: Acute and chronic hepatitis in children . Postgrad Med J 63:191-200, 1978. 13. Mihas AA, Conrad ME: Hepatitis B antigen and the liver . Medicine 57:129-150, 1978.Crossref 14. Berman M, Alter HJ, Ishak KG, et al: The chronic sequelae of non-A, non-B hepatitis . Ann Intern Med 91:1-6, 1979.Crossref 15. Knodell RG, Conrad ME, Ishak KG: Development of chronic liver disease after acute non-A, non-B posttransfusion hepatitis: Role of γ-globulin prophylaxis in its prevention . Gastroenterology 72:902-909, 1977. 16. Barton JC, Conrad ME: Beneficial effects of hepatitis in patients with acute myelogenous leukemia . Ann Intern Med 90:188-190, 1979.Crossref 17. George SL, Aur RJA, Mauer AM, et al: A reappraisal of the results of stopping therapy in childhood leukemia . N Engl J Med 300:269-273, 1979.Crossref 18. Harris RC, Tabar E: When is hepatitis chronic? J Pediatr 95:551-552, 1979.Crossref

Journal

American Journal of Diseases of ChildrenAmerican Medical Association

Published: Jun 1, 1980

References