Abstract After the isolation and identification of radium by the Curies, radium and other closely related radioactive elements were utilized in the treatment of a number of medical disorders, particularly gout,1 arthritis,2,3 syphilis,4 hypertension,5 epilepsy, multiple sclerosis,6 leukemia,7 and various types of anemia.8-10 The oral and intravenous use of radium was well established not only in this country, but also abroad. Although the toxic manifestations of radium and its associated elements were not well defined at that time, there was, nonetheless, much enthusiasm for this mode of therapy because of the presumed clinical improvement in a large number of cases. Looney et al.11 recently emphasized that toxic effects were not anticipated to develop 10 to 20 years after the use of radium therapy. It has been stated that the administration of soluble radium salts has continued, at intervals, until the present time in References 1. Furstenberg, A.: Radium Emanation Treatment for Rheumatism and Gout , Radium 1:13, 1913. 2. Finch, A. E. H.: Treatment of Arthritis Deformans with Radium Emanation Solution: Report of Work Carried out at Radium Institute, London , Radium 12:20, 1918. 3. Cameron, W. H.: Radium Emanation Therapy in Arthritis Deformans , Radium 1:3, 1915. 4. Ayres, W.: Effect of Intravenous Injections of Radium on Persistent Positive Wasserman Reaction , Med. Rec. 88:610, 1915. 5. Proescher, F.: Influence of Intravenous Injection of Soluble Radium Salts on High Blood Pressure , Radium 3:1, 1914. 6. Looney, W. B., and Woodruff, L. A.: Investigation of Radium Deposition in Human Skeleton by Gross and Detailed Autoradiography , A.M.A. Arch. Path. 56:1, 1953. 7. Proescher, F.: Contribution on Therapeutic Value of Intravenous Injection of Soluble Radium Salts in Treatment of Pernicious Anemia and Leukemia , Radium 7:71, 1916. 8. Martland, H. S.: Histopathology of Certain Anemias Due to Radioactivity , Proc. N.Y. Path. Soc. 26:65, 1926. 9. Proescher, F.: Conclusions Concerning the Value of Radium Therapy in Pernicious Anemia , Radium 7:102, 1916. 10. Reitter, G. S., and Martland, H. S.: Leukopenic Anemia of the Regenerative Type Due to Exposure to Radium and Mesothorium , Amer. J. Roentgenol. 16:161, 1926. 11. Looney, W. B.; Hasterlik, R. J.; Brues, A. M., and Skirmont, E.: A Clinical Investigation of the Chronic Effects of Radium Salts Administered Therapeutically , Amer. J. Roentgenol. 73:1006, 1955. 12. Hoffman, F. L.: Radium (Mesothorium) Necrosis , J.A.M.A. 85:961, 1925.Crossref 13. Martland, H. S.: Occurrence of Malignancy in Radioactive Persons , Amer. J. Cancer 15:2435, 1931. 14. Flinn, F. B.: Stimulating Action of Radioactive Deposits in the Body , Radiology 23:331, 1934.Crossref 15. Martland, H. S.: Occupational Poisoning in Manufacture of Luminous Watch Dials , J.A.M.A. 92:466-552, 1929.Crossref 16. Aub, J. C.; Evans, R. D.; Hemplemann, L. H., and Martland, H. S.: Late Effects of Internally Deposited Radioactive Materials in Man , Medicine 31:221, 1952.Crossref 17. Martland, H. S., and Humphrey, R. E.: Osteogenic Sarcoma in Dial Painters Using Luminous Paint , Arch. Path. 7:406, 1929.
Archives of Surgery – American Medical Association
Published: Feb 1, 1963
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