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Orbital Carcinoid Tumor-Reply

Orbital Carcinoid Tumor-Reply Abstract In Reply. —We very much appreciate the interest of Font et al in our article. When our patient was first seen in 1982, the slides were reviewed in consultation with numerous surgical pathologists, neuropathologists, and ophthalmic pathologists at six medical institutions across the country. There was a consensus that the tumor was neuroendocrine in nature. The diagnoses included esthesioneuroblastoma, metastatic carcinoid tumor, neuroblastoma, and paraganglioma, with the majority favoring a diagnosis of neuroblastoma. At that time, specific keratin antibody stains, as performed by Dr Battifora, were not available.We reviewed Dr Battifora's slides and agree with his interpretation of the tumor's keratin positivity. A polyclonal broad-spectrum antikeratin stain was questionably positive in our laboratory while our anti-AE1/AE3 was strongly positive. The keratin positivity effectively includes a neuroblastoma and is very strong evidence in favor of a carcinoid tumor. In view of these new findings, we completely agree that this is References 1. Zimmerman LE, Stangl R, Riddle PJ. Primary carcinoid tumor of the orbit: a clinicopathologic study with histochemical and electron microscopic observations . Arch Ophthalmol . 1983;101:1395-1398.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Ophthalmology American Medical Association

Orbital Carcinoid Tumor-Reply

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Orbital Carcinoid Tumor-Reply

Abstract

Abstract In Reply. —We very much appreciate the interest of Font et al in our article. When our patient was first seen in 1982, the slides were reviewed in consultation with numerous surgical pathologists, neuropathologists, and ophthalmic pathologists at six medical institutions across the country. There was a consensus that the tumor was neuroendocrine in nature. The diagnoses included esthesioneuroblastoma, metastatic carcinoid tumor, neuroblastoma, and paraganglioma, with the...
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Publisher
American Medical Association
Copyright
Copyright © 1991 American Medical Association. All Rights Reserved.
ISSN
0003-9950
eISSN
1538-3687
DOI
10.1001/archopht.1991.01080030017004
Publisher site
See Article on Publisher Site

Abstract

Abstract In Reply. —We very much appreciate the interest of Font et al in our article. When our patient was first seen in 1982, the slides were reviewed in consultation with numerous surgical pathologists, neuropathologists, and ophthalmic pathologists at six medical institutions across the country. There was a consensus that the tumor was neuroendocrine in nature. The diagnoses included esthesioneuroblastoma, metastatic carcinoid tumor, neuroblastoma, and paraganglioma, with the majority favoring a diagnosis of neuroblastoma. At that time, specific keratin antibody stains, as performed by Dr Battifora, were not available.We reviewed Dr Battifora's slides and agree with his interpretation of the tumor's keratin positivity. A polyclonal broad-spectrum antikeratin stain was questionably positive in our laboratory while our anti-AE1/AE3 was strongly positive. The keratin positivity effectively includes a neuroblastoma and is very strong evidence in favor of a carcinoid tumor. In view of these new findings, we completely agree that this is References 1. Zimmerman LE, Stangl R, Riddle PJ. Primary carcinoid tumor of the orbit: a clinicopathologic study with histochemical and electron microscopic observations . Arch Ophthalmol . 1983;101:1395-1398.Crossref

Journal

Archives of Ophthalmology – American Medical Association

Published: Mar 1, 1991

References

  • Primary carcinoid tumor of the orbit: a clinicopathologic study with histochemical and electron microscopic observations
    Zimmerman LE, Stangl R, Riddle PJ

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