Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You and Your Team.

Learn More →

Oral Urea as an Osmotic Ocular Hypotensive Agent

Oral Urea as an Osmotic Ocular Hypotensive Agent Abstract The use of osmotic agents in the treatment of all types of glaucoma has recently received impetus from the introduction of urea into clinical ophthalmology.1 The theoretical superiority of this drug as compared to previously used osmotic solutions has been well substantiated. Its low molecular weight, relatively poor ocular penetrance, and inertness make it eminently successful as an ocular hypotensive agent. However, though the effects of oral urea have been reported,2 most studies have dealt with the intravenous route of administration. Furthermore, no discussion has appeared relating intraocular pressure to oral urea administration. Consequently, with this latter thought in mind, the present study was undertaken. Materials and Methods Patients were obtained from the glaucoma clinic of The New York Hospital. Early pilot experiments revealed that absorption of the material was excellent, and that high blood levels could be obtained. A dosage level of 1.5 gm. per kilogram was References 1. Galin, M. A.; Aizawa, F., and McLean, J. M.: Urea as an Osmotic Ocular Hypotensive Agent in Glaucoma , A.M.A. Arch. Ophth. 62:347-352 ( (Sept.) ) 1959.Crossref 2. Javid, M.: Urea—New Use of an Old Agent: Reduction of Intracranial and Intraocular Pressure , S. Clin. North America 38:907-928 ( (Aug.) ) 1958. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png A.M.A. Archives of Ophthalmology American Medical Association

Oral Urea as an Osmotic Ocular Hypotensive Agent

Loading next page...
 
/lp/american-medical-association/oral-urea-as-an-osmotic-ocular-hypotensive-agent-0EjpqTWY1h
Publisher
American Medical Association
Copyright
Copyright © 1959 American Medical Association. All Rights Reserved.
ISSN
0096-6339
DOI
10.1001/archopht.1959.04220060171013
Publisher site
See Article on Publisher Site

Abstract

Abstract The use of osmotic agents in the treatment of all types of glaucoma has recently received impetus from the introduction of urea into clinical ophthalmology.1 The theoretical superiority of this drug as compared to previously used osmotic solutions has been well substantiated. Its low molecular weight, relatively poor ocular penetrance, and inertness make it eminently successful as an ocular hypotensive agent. However, though the effects of oral urea have been reported,2 most studies have dealt with the intravenous route of administration. Furthermore, no discussion has appeared relating intraocular pressure to oral urea administration. Consequently, with this latter thought in mind, the present study was undertaken. Materials and Methods Patients were obtained from the glaucoma clinic of The New York Hospital. Early pilot experiments revealed that absorption of the material was excellent, and that high blood levels could be obtained. A dosage level of 1.5 gm. per kilogram was References 1. Galin, M. A.; Aizawa, F., and McLean, J. M.: Urea as an Osmotic Ocular Hypotensive Agent in Glaucoma , A.M.A. Arch. Ophth. 62:347-352 ( (Sept.) ) 1959.Crossref 2. Javid, M.: Urea—New Use of an Old Agent: Reduction of Intracranial and Intraocular Pressure , S. Clin. North America 38:907-928 ( (Aug.) ) 1958.

Journal

A.M.A. Archives of OphthalmologyAmerican Medical Association

Published: Dec 1, 1959

References