Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

ORAL PENICILLIN

ORAL PENICILLIN The early studies on the absorption of penicillin indicated that most of an orally administered dose is probably destroyed by the acidity of the normal stomach. Nevertheless, the small amounts recovered from the urine and the demonstration of activity in the serum suggested that some absorption does take place.1 When, more recently, doses of 100,000 units were given on an empty stomach, the amounts excreted in the urine were the same as or larger than the quantities usually given in a single intramuscular injection,2 suggesting that the oral method is feasible if larger doses are used. A number of antacids, buffers, capsules and oils have been used in attempts to protect the penicillin from the acidity of the stomach. These, as well as substances intended to increase absorption, have given conflicting results.3 Almost all workers found wide variations in absorption by different persons. Although some have suggested http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA American Medical Association

Loading next page...
 
/lp/american-medical-association/oral-penicillin-7ARY0V3zcp

References (0)

References for this paper are not available at this time. We will be adding them shortly, thank you for your patience.

Publisher
American Medical Association
Copyright
Copyright © 1945 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
0098-7484
eISSN
1538-3598
DOI
10.1001/jama.1945.02860390001001
Publisher site
See Article on Publisher Site

Abstract

The early studies on the absorption of penicillin indicated that most of an orally administered dose is probably destroyed by the acidity of the normal stomach. Nevertheless, the small amounts recovered from the urine and the demonstration of activity in the serum suggested that some absorption does take place.1 When, more recently, doses of 100,000 units were given on an empty stomach, the amounts excreted in the urine were the same as or larger than the quantities usually given in a single intramuscular injection,2 suggesting that the oral method is feasible if larger doses are used. A number of antacids, buffers, capsules and oils have been used in attempts to protect the penicillin from the acidity of the stomach. These, as well as substances intended to increase absorption, have given conflicting results.3 Almost all workers found wide variations in absorption by different persons. Although some have suggested

Journal

JAMAAmerican Medical Association

Published: Sep 29, 1945

There are no references for this article.