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Optical Coherence Tomography in Neuromyelitis Optica

Optical Coherence Tomography in Neuromyelitis Optica ORIGINAL CONTRIBUTION Optical Coherence Tomography in Neuromyelitis Optica Je´roˆme de Seze, MD, PhD; Frederic Blanc, MD; Luc Jeanjean, MD; He´lène Ze´phir, MD; Pierre Labauge, MD, PhD; Marie Bouyon, MD; Laurent Ballonzoli, MD; Giovanni Castelnovo, MD; Marie Fleury, MD; Sabine Defoort, MD; Patrick Vermersch, MD, PhD; Claude Speeg, MD, PhD Background: Neuromyelitis optica (NMO) is an in- Results: Optical coherence tomography and visual field flammatory disease with combined features of optic neu- data were available for only 32 patients because 3 pa- ritis and myelitis. This pathologic entity may induce se- tients were blind. The mean retinal nerve fiber layer thick- vere disability, including visual loss and paraplegia. Other ness was significantly reduced in patients with NMO com- than clinical follow-up, there is no marker for severity pared with controls (P.001). We found good correlation of the disease. between the OCT results and visual field testing. We also found weak correlation between OCT results and both Objectives: To evaluate the use of optical coherence to- visual acuity and visual evoked potential latencies. We mography (OCT) in NMO and to determine whether this did not find any correlation between OCT results and age, newtechniquecouldbeagoodmarkerofaxonallossinNMO. sex, or disease duration. In contrast, retinal http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA Neurology American Medical Association

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Publisher
American Medical Association
Copyright
Copyright 2008 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
2168-6149
eISSN
2168-6157
DOI
10.1001/archneur.65.7.920
pmid
18625858
Publisher site
See Article on Publisher Site

Abstract

ORIGINAL CONTRIBUTION Optical Coherence Tomography in Neuromyelitis Optica Je´roˆme de Seze, MD, PhD; Frederic Blanc, MD; Luc Jeanjean, MD; He´lène Ze´phir, MD; Pierre Labauge, MD, PhD; Marie Bouyon, MD; Laurent Ballonzoli, MD; Giovanni Castelnovo, MD; Marie Fleury, MD; Sabine Defoort, MD; Patrick Vermersch, MD, PhD; Claude Speeg, MD, PhD Background: Neuromyelitis optica (NMO) is an in- Results: Optical coherence tomography and visual field flammatory disease with combined features of optic neu- data were available for only 32 patients because 3 pa- ritis and myelitis. This pathologic entity may induce se- tients were blind. The mean retinal nerve fiber layer thick- vere disability, including visual loss and paraplegia. Other ness was significantly reduced in patients with NMO com- than clinical follow-up, there is no marker for severity pared with controls (P.001). We found good correlation of the disease. between the OCT results and visual field testing. We also found weak correlation between OCT results and both Objectives: To evaluate the use of optical coherence to- visual acuity and visual evoked potential latencies. We mography (OCT) in NMO and to determine whether this did not find any correlation between OCT results and age, newtechniquecouldbeagoodmarkerofaxonallossinNMO. sex, or disease duration. In contrast, retinal

Journal

JAMA NeurologyAmerican Medical Association

Published: Jul 1, 2008

References