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Optic Neuritis and Multiple Sclerosis: An Epidemiologic Study

Optic Neuritis and Multiple Sclerosis: An Epidemiologic Study Abstract Since optic neuritis occurs frequently in multiple sclerosis (MS), it has been thought to herald the onset of MS in the young adult where no specific cause can be identified. This study was designed to examine the incidence of optic neuritis in the resident population of Rochester, Minn, in order to clarify the relationship between optic neuritis and MS. Thirteen to fifteen percent of the patients with MS in the Rochester population presented with optic neuritis, and 27% to 37% of the MS patients showed evidence of optic neuritis during the course of their disease. Prospective analysis of idiopathic optic neuritis cases revealed that the chance of its progressing to MS was approximately 17%. The unfavorable prognosis previously associated with idiopathic optic neuritis may be the result of a bias of clinical series. References 1. Kurland LT, Auth TL, Beebe GW, et al: Studies on the natural history of multiple sclerosis: II. Optic neuritis as a prelude to multiple sclerosis . Acta Neurol Sand 42( (suppl 19) ):157-176, 1966.Crossref 2. Lynn BH: Retrobulbar neuritis: A survey of the present condition of cases occurring over the last 56 years . Trans Ophthal Soc UK 79:701-716, 1959. 3. McAlpine D: The benign form of multiple sclerosis: Results of a long-term study . Brit Med J 2:1029-1032, 1964.Crossref 4. Perey AK, Kurland LT, Nobrega FT, et al: Multiple sclerosis in Rochester, Minnesota: A 60-year appraisal . Trans Amer Neurol Assoc 93:264-265, 1968. 5. Kurland LT, Elveback LR, Nobrega FT: Population studies in Rochester and Olmsted County, Minnesota, 1900-1968 , in Kessler II, Levin ML (eds): The Community as an Epidemiologic Laboratory: A Casebook of Community Studies . Baltimore, Johns Hopkins Press, 1970, pp 47-70. 6. Hyllested K, Moller PM: Follow-up on patients with a history of optic neuritis . Acta Ophthal 39:655-662, 1961.Crossref 7. Kurland LT: Descriptive epidemiology of selected neurologic and myopathic disorders with particular reference to a survey in Rochester, Minnesota . J Chronic Dis 8:378-418, 1958.Crossref 8. Brewis M, Poskanzer DC, Rolland C, et al: Neurological disease in an English city . Acta Neurol Scand 42( (suppl 24) ):1-89, 1966. 9. Walsh FB, Hoyt WF: Clinical Neuro-Ophthalmology , ed 3. Baltimore, Williams & Wilkins Co, 1969, vol 1, p 987. 10. Leibowitz U, Alter M, Halpern L: Clinical studies of multiple sclerosis in Israel: IV. Optic neuropathy and multiple sclerosis . Arch Neurol 14:459-466, 1966.Crossref 11. Taub RG, Rucker CW: The relationship of retrobulbar neuritis to multiple sclerosis . Amer J Ophthal 37:494-497, 1954. 12. Bradley WG, Whitty CWM: Acute optic neuritis: Prognosis for development of multiple sclerosis . J Neurol Neurosurg Psychiat 31:10-18, 1968.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Ophthalmology American Medical Association

Optic Neuritis and Multiple Sclerosis: An Epidemiologic Study

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Publisher
American Medical Association
Copyright
Copyright © 1972 American Medical Association. All Rights Reserved.
ISSN
0003-9950
eISSN
1538-3687
DOI
10.1001/archopht.1972.01000020137004
Publisher site
See Article on Publisher Site

Abstract

Abstract Since optic neuritis occurs frequently in multiple sclerosis (MS), it has been thought to herald the onset of MS in the young adult where no specific cause can be identified. This study was designed to examine the incidence of optic neuritis in the resident population of Rochester, Minn, in order to clarify the relationship between optic neuritis and MS. Thirteen to fifteen percent of the patients with MS in the Rochester population presented with optic neuritis, and 27% to 37% of the MS patients showed evidence of optic neuritis during the course of their disease. Prospective analysis of idiopathic optic neuritis cases revealed that the chance of its progressing to MS was approximately 17%. The unfavorable prognosis previously associated with idiopathic optic neuritis may be the result of a bias of clinical series. References 1. Kurland LT, Auth TL, Beebe GW, et al: Studies on the natural history of multiple sclerosis: II. Optic neuritis as a prelude to multiple sclerosis . Acta Neurol Sand 42( (suppl 19) ):157-176, 1966.Crossref 2. Lynn BH: Retrobulbar neuritis: A survey of the present condition of cases occurring over the last 56 years . Trans Ophthal Soc UK 79:701-716, 1959. 3. McAlpine D: The benign form of multiple sclerosis: Results of a long-term study . Brit Med J 2:1029-1032, 1964.Crossref 4. Perey AK, Kurland LT, Nobrega FT, et al: Multiple sclerosis in Rochester, Minnesota: A 60-year appraisal . Trans Amer Neurol Assoc 93:264-265, 1968. 5. Kurland LT, Elveback LR, Nobrega FT: Population studies in Rochester and Olmsted County, Minnesota, 1900-1968 , in Kessler II, Levin ML (eds): The Community as an Epidemiologic Laboratory: A Casebook of Community Studies . Baltimore, Johns Hopkins Press, 1970, pp 47-70. 6. Hyllested K, Moller PM: Follow-up on patients with a history of optic neuritis . Acta Ophthal 39:655-662, 1961.Crossref 7. Kurland LT: Descriptive epidemiology of selected neurologic and myopathic disorders with particular reference to a survey in Rochester, Minnesota . J Chronic Dis 8:378-418, 1958.Crossref 8. Brewis M, Poskanzer DC, Rolland C, et al: Neurological disease in an English city . Acta Neurol Scand 42( (suppl 24) ):1-89, 1966. 9. Walsh FB, Hoyt WF: Clinical Neuro-Ophthalmology , ed 3. Baltimore, Williams & Wilkins Co, 1969, vol 1, p 987. 10. Leibowitz U, Alter M, Halpern L: Clinical studies of multiple sclerosis in Israel: IV. Optic neuropathy and multiple sclerosis . Arch Neurol 14:459-466, 1966.Crossref 11. Taub RG, Rucker CW: The relationship of retrobulbar neuritis to multiple sclerosis . Amer J Ophthal 37:494-497, 1954. 12. Bradley WG, Whitty CWM: Acute optic neuritis: Prognosis for development of multiple sclerosis . J Neurol Neurosurg Psychiat 31:10-18, 1968.Crossref

Journal

Archives of OphthalmologyAmerican Medical Association

Published: Feb 1, 1972

References

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