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Optic Nerve Involvement Associated with Thyroid Dysfunction

Optic Nerve Involvement Associated with Thyroid Dysfunction Abstract Ten patients with optic nerve involvement associated with thyroid dysfunction are reported in this study. This is the largest group reported from any one institution. Such optic nerve disease is relatively uncommon, and most reports in the literature are limited to one or two cases. However, 2 series of 6 cases1,2 and 1 of 43 have been published in sufficient detail within recent years to be of value for comparison. Each patient had orbital changes characteristic of those associated with Graves' disease. These consisted of tearing and irritation of the eyes, as well as upper lid retraction, deep injection at the outer aspects of the globes, lid swelling, chemosis, and extraocular muscle involvement. All these signs were not present in every patient, but the clinical picture in each case suggested the correct diagnosis. Only one patient showed any corneal irregularity, and this was slight. The fundi were examined References 1. Thyroglobulin preparation containing 0.2% iodine in organic combination. 2. Hedges, T. R., Jr., and Scheie, H. G.: Visual Field Defects in Exophthalmos Associated with Thyroid Disease , A.M.A. Arch. Ophthal. 54:885, 1955.Crossref 3. Henderson, J. W.: Optic Neuropathy of Exophthalmic Goiter (Graves' Disease) , A.M.A. Arch. Ophthal. 59:471, 1958.Crossref 4. Igersheimer, J.: Visual Changes in Progressive Exophthalmos , A.M.A. Arch. Ophthal. 53:94, 1955.Crossref 5. Braley, A. E.: Malignant Exophthalmos , Amer. J. Ophthal. 36:1286, 1953. 6. Weekers, R., and Lavergne, G.: Changes in Ocular Rigidity in Endocrine Exophthalmos , Brit. J. Ophthal. 42:680, 1958.Crossref 7. Day, R.: Ocular Manifestations of Thyroid Disease: Current Concepts , Trans. Amer. Ophthal. Soc. 57:572, 1959. 8. Sloan, L. W.: Surgical Treatment of Hyperthyroidism , New York J. Med. 51:2897, 1951. 9. Brain, R., et al.: Discussion on the Management of Endocrine Exophthalmos , Proc. Roy. Soc. Med. 45:238, 1952. 10. Tengroth, B.: The Effect of D-Thyroxin on Experimentally TSH-Induced Exophthalmos in Guinea Pigs , Trans. Ophthal. Soc. U.K. 80:131, 1960. 11. Werner, S. C.: The Thyroid: A Fundamental and Clinical Text , New York, Paul B. Hoeber, Inc., Medical Book Department of Harper & Brothers, 1955. 12. Poppen, J. L.: Intractable Exophthalmos in Thyroid Disease , Postgrad. Med. 14:130, 1953. 13. Brain, W. R.: Exophthalmic Ophthalmoplegia , Quart. J. Med. 7:293, 1938. 14. Merrill, H. G., and Oaks, L. W.: Extreme Bilateral Exophthalmos: Report of 2 Cases with Autopsy Findings in 1 , Amer. J. Ophthal. 16:231, 1933. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Ophthalmology American Medical Association

Optic Nerve Involvement Associated with Thyroid Dysfunction

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Publisher
American Medical Association
Copyright
Copyright © 1962 American Medical Association. All Rights Reserved.
ISSN
0003-9950
eISSN
1538-3687
DOI
10.1001/archopht.1962.00960020291004
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Abstract

Abstract Ten patients with optic nerve involvement associated with thyroid dysfunction are reported in this study. This is the largest group reported from any one institution. Such optic nerve disease is relatively uncommon, and most reports in the literature are limited to one or two cases. However, 2 series of 6 cases1,2 and 1 of 43 have been published in sufficient detail within recent years to be of value for comparison. Each patient had orbital changes characteristic of those associated with Graves' disease. These consisted of tearing and irritation of the eyes, as well as upper lid retraction, deep injection at the outer aspects of the globes, lid swelling, chemosis, and extraocular muscle involvement. All these signs were not present in every patient, but the clinical picture in each case suggested the correct diagnosis. Only one patient showed any corneal irregularity, and this was slight. The fundi were examined References 1. Thyroglobulin preparation containing 0.2% iodine in organic combination. 2. Hedges, T. R., Jr., and Scheie, H. G.: Visual Field Defects in Exophthalmos Associated with Thyroid Disease , A.M.A. Arch. Ophthal. 54:885, 1955.Crossref 3. Henderson, J. W.: Optic Neuropathy of Exophthalmic Goiter (Graves' Disease) , A.M.A. Arch. Ophthal. 59:471, 1958.Crossref 4. Igersheimer, J.: Visual Changes in Progressive Exophthalmos , A.M.A. Arch. Ophthal. 53:94, 1955.Crossref 5. Braley, A. E.: Malignant Exophthalmos , Amer. J. Ophthal. 36:1286, 1953. 6. Weekers, R., and Lavergne, G.: Changes in Ocular Rigidity in Endocrine Exophthalmos , Brit. J. Ophthal. 42:680, 1958.Crossref 7. Day, R.: Ocular Manifestations of Thyroid Disease: Current Concepts , Trans. Amer. Ophthal. Soc. 57:572, 1959. 8. Sloan, L. W.: Surgical Treatment of Hyperthyroidism , New York J. Med. 51:2897, 1951. 9. Brain, R., et al.: Discussion on the Management of Endocrine Exophthalmos , Proc. Roy. Soc. Med. 45:238, 1952. 10. Tengroth, B.: The Effect of D-Thyroxin on Experimentally TSH-Induced Exophthalmos in Guinea Pigs , Trans. Ophthal. Soc. U.K. 80:131, 1960. 11. Werner, S. C.: The Thyroid: A Fundamental and Clinical Text , New York, Paul B. Hoeber, Inc., Medical Book Department of Harper & Brothers, 1955. 12. Poppen, J. L.: Intractable Exophthalmos in Thyroid Disease , Postgrad. Med. 14:130, 1953. 13. Brain, W. R.: Exophthalmic Ophthalmoplegia , Quart. J. Med. 7:293, 1938. 14. Merrill, H. G., and Oaks, L. W.: Extreme Bilateral Exophthalmos: Report of 2 Cases with Autopsy Findings in 1 , Amer. J. Ophthal. 16:231, 1933.

Journal

Archives of Ophthalmology – American Medical Association

Published: Mar 1, 1962

References

  • Visual Field Defects in Exophthalmos Associated with Thyroid Disease
    Hedges , T. R., Jr., and Scheie, H. G.
  • Optic Neuropathy of Exophthalmic Goiter (Graves' Disease)
    Henderson , J. W.
  • Visual Changes in Progressive Exophthalmos
    Igersheimer , J.
  • Malignant Exophthalmos
    Braley , A. E.
  • Changes in Ocular Rigidity in Endocrine Exophthalmos
    Weekers , R., and Lavergne, G.
  • Ocular Manifestations of Thyroid Disease: Current Concepts
    Day , R.
  • Surgical Treatment of Hyperthyroidism
    Sloan , L. W.
  • Discussion on the Management of Endocrine Exophthalmos
    Brain , R., et al.
  • The Effect of D-Thyroxin on Experimentally TSH-Induced Exophthalmos in Guinea Pigs
    Tengroth , B.
  • The Thyroid: A Fundamental and Clinical Text
    Werner , S. C.
  • Intractable Exophthalmos in Thyroid Disease
    Poppen , J. L.
  • Exophthalmic Ophthalmoplegia
    Brain , W. R.
  • Extreme Bilateral Exophthalmos: Report of 2 Cases with Autopsy Findings in 1
    Merrill , H. G., and Oaks, L. W.