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Ophthalmic Manifestations of the Wiskott-Aldrich Syndrome

Ophthalmic Manifestations of the Wiskott-Aldrich Syndrome Abstract Ophthalmic disease was described in three patients with the Wiskott-Aldrich syndrome, an entity characterized by eczema, thrombocytopenia, and recurrent infections, and inherited in a sex-linked fashion. Blepharoconjunctivitis. associated with molluscum contagiosum, and herpes simplex keratitis, isolated or accompanied by disseminated mucocutaneous herpes simplex virus infection or both, were found. In 18 of the 80 cases of the Wiskott-Aldrich syndrome documented in the literature, ocular complications were present. References 1. Wiskott, A.: Familiärer, angeborener Morbus Werlhofii? , Mschr Kinderheilk 68:212-216 ( (July) ) 1937. 2. Aldrich, R.A.; Steinberg, A.G.; and Campbell, D.C.: Pedigree Demonstrating a Sex-Linked Recessive Condition Characterized by Draining Ears, Eczematoid Dermatitis, and Bloody Diarrhea , Pediatrics 13:133-139 ( (Feb) ) 1954. 3. Wolff, J.A., and Bertucio, M.: A Sex-Linked Genetic Syndrome in a Negro Family Manifested by Thrombocytopenia, Eczema, Bloody Diarrhea, Recurrent Infection. Anemia, and Epistaxis , J Dis Child 93:74 ( (Jan) ) 1957. 4. Huntley, C.C., and Dees, S.C.: Eczema Associated With Thrombocytopenic Purpura and Purulent Otitis Media: Report of Five Fatal Cases , Pediatrics 19:351-361 ( (March) ) 1957. 5. Sansone, G.: Porpora trombopenica del lattante associata a malformazioni multiple ed a spiccata suscettibilità alle infezioni: Rapporti con la sindrome di Aldrich , Minerva Pediat 10:677-684, 1958. 6. Krivit, W., and Good, R.A.: Aldrich's Syndrome (Thrombocytopenia, Eczema, and Infection in Infants): Studies of the Defense Mechanisms , J Dis Child 97:137-153 ( (Feb) ) 1959.Crossref 7. Mills, S.D., and Winkelmann, R.K.: Eczema, Thrombocytopenic Purpura, and Recurring Infections: A Familial Disorder With Report of Four Families , Arch Derm 79:466-472 ( (April) ) 1959.Crossref 8. Midulla, M.: Porpora trombocitopenica associata ad eczema ed infezioni in tre bambini di sesso maschile appartenenti ad una stessa famiglia (sindrome di Aldrich): Comunicazione preliminare , Arch Ital Pediat 20:264-271, 1959. 9. Cummins, L., et al: Aldrich Syndrome in Twins , J Dis Child 98:579-580 ( (Nov) ) 1959. 10. Gordon, R.R.: Aldrich's Syndrome: Familial Thrombocytopenia, Eczema and Infection , Arch Dis Child 35:259-265 ( (June) ) 1960.Crossref 11. Rivera, A.M., and Biehusen, F.C.: Aldrich's Syndrome: Report of a Case With Subperiosteal Hemorrhage , J Pediat 57:86-88 ( (July) ) 1960.Crossref 12. Pierson, M.; Lascombes, G.; and Manciaux, M.: Syndrome d' Aldrich , Sem Hop Paris 36:2630-2632 ( (Oct 24) ) 1960. 13. Eitzman, D.V., and Smith, R.T.: Immunologic Studies on a Patient With Aldrich's Syndrome , Southern Med J 53:1593 ( (Dec) ) 1960. 14. Cassimos, C., et al: Aldrich's Syndrome (Thrombocytopenia, Eczema, and Recurrent Infections): Report of a Case , Amer J Dis Child 100:914-917 ( (Dec) ) 1960.Crossref 15. Coleman, A.; Leiken, S.; and Guin, G.H.: Aldrich's Syndrome , Clin Proc Child Hosp DC 17:22-27 ( (Jan) ) 1961. 16. Kildeberg, P.: The Aldrich Syndrome: Report of a Case and Discussion of Pathogenesis , Pediatrics 27:362-369 ( (March) ) 1961. 17. Gelzer, J., and Gasser, C.: Wiskott-Aldrich Syndrom , Helv Paediat Acta 16:17-39 ( (April) ) 1961. 18. Baker, D.H.; Parmer, E.A.; and Wolff, J.A.: Roentgen Manifestation of the Aldrich Syndrome , Amer J Roentgen 88:458-465 ( (Sept) ) 1962. 19. Gualdoni, C.: Un caso di morbo di Aldrich , Minerva Nipiol 12:370-371, 1962. 20. Root, A.W., and Speicher, C.E.: The Triad of Thrombocytopenia, Eczema, and Recurrent Infections (Wiskott-Aldrich Syndrome) Associated With Milk Antibodies, Giant-Cell Pneumonia, and Cytomegalic Inclusion Disease , Pediatrics 31:444-454 ( (March) ) 1963. 21. Niordson, A., and Schmidt, H.: Aldrich's Syndrome: A Report of Two Cases , Arch Derm 88:613-615 ( (Nov) ) 1963.Crossref 22. Marchal, G., et al: Le syndrome d' Aldrich (purpura thrombopénique familial, eczéma, infections récidivantes) , Presse Med 71:2621-2624 ( (Dec 21) ) 1963. 23. Palmgren, B., and Lindberg, T.: Immunological Studies in Wiskott-Aldrich Syndrome , Acta Paediat , (suppl 146) , pp 116-121, 1963. 24. Weintraub, H.D., and Wilson, W.J.: Pneumocystis carinii Pneumonia in Wiskott-Aldrich Syndrome , Amer J Dis Child 108:198-200 ( (Aug) ) 1964. 25. Johnson, G.M.; Burke, E.C.; and Burgert, E.O., Jr.: Wiskott-Aldrich Syndrome: Report of an Additional Case , Proc Staff Meet Mayo Clin 39:258-262 ( (April) ) 1964. 26. Lanzkowsky, P., and Levy, S.: The Triad of Thrombocytopenia, Eczema and Infection (Wiskott-Aldrich's Syndrome) , S Afr Med J 39:280-282 ( (April 10) ) 1965. 27. Dalloz, J.C., et al: Paraprotéinémie transitoire de type gamma: Observation chez un nourrisson atteint du syndrome d' Aldrich , Presse Med 73:1541-1546 ( (May 26) ) 1965. 28. St. Geme, J.W., Jr., et al: Impaired Cellular Resistance to Herpes-Simplex Virus in Wiskott-Aldrich Syndrome , New Eng J Med 273:229-234 ( (July 29) ) 1965.Crossref 29. Hastrup, J., and Grahl-Madsen, R.: Wiskott-Aldrich's Syndrome: Thrombocytopenia, Eczema and Recurrent Infection , Danish Med Bull 12:99-102 ( (Aug) ) 1965. 30. ten Bensel, R.W.; Stadlan, E.M.; and Krivit, W.: The Development of Malignancy in the Course of the Aldrich Syndrome , J Pediat 68:761-767 ( (May) ) 1966.Crossref 31. Pearson, H.A., et al: Platelet Survival in Wiskott-Aldrich Syndrome , J Pediat 68:754-760 ( (May) ) 1966.Crossref 32. Chaptal, J., et al: Syndrome de Wiskott-Aldrich avec survie prolongee (9 ans): Evolution mortelle par thymosarcome , Arch Franc Pediat 23:907-920 ( (Oct) ) 1966. 33. Kalus, M., and Holub, J.: Aldrich-Wiskott-Syndrome With Thrombocytophagy and Lipopigment in the Reticuloendothelial System , Folia Haemat (Leipzig) 86:164-173, 1966. 34. Wolff, J.A.: Wiskott-Aldrich Syndrome: Clinical, Immunologic, and Pathologic Observations , J Pediat 70:221-232 ( (Feb) ) 1967.Crossref 35. Berglund, G., et al: Wiskott-Aldrich Syndrome: A Study of Six Cases With Determination of the Immunoglobulins A, D, G, M, and ND , Acta Paediat Scand 57:89-97 ( (March) ) 1968.Crossref 36. Cooper, M.D., et al: Wiskott-Aldrich Syndrome: An Immunologic Deficiency Disease Involving the Afferent Limb of Immunity , Amer J Med 44:499-513 ( (April) ) 1968.Crossref 37. Krivit, W.; Yunis, E.; and White, J.G.: Platelet Survival Studies in Aldrich Syndrome , Pediatrics 37:339-341 ( (Feb) ) 1966. 38. Duke-Elder, S.: Diseases of the Outer Eye , System of Ophthalmology , St. Louis: The C. V. Mosby Co., 1965, vol 8, pt 1, pp 310-312. 39. Blaese, R.M., et al: The Wiskott-Aldrich Syndrome: A Disorder With a Possible Defect in Antigen Processing or Recognition , Lancet 1:1056-1061 ( (May 18) ) 1968.Crossref 40. Rosen, F.S., and Janeway, C.A.: The Gamma Globulins: III. The Antibody Deficiency Syndromes , New Eng J Med 275:709-715 ( (Sept 29) ) 1966.Crossref 41. Kretschmer, R., et al: Congenital Aplasia of the Thymus Gland (DiGeorge's Syndrome) , New Eng J Med 279:1295-1301 ( (Dec 12) ) 1968.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Ophthalmology American Medical Association

Ophthalmic Manifestations of the Wiskott-Aldrich Syndrome

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Publisher
American Medical Association
Copyright
Copyright © 1969 American Medical Association. All Rights Reserved.
ISSN
0003-9950
eISSN
1538-3687
DOI
10.1001/archopht.1969.00990020324005
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Abstract

Abstract Ophthalmic disease was described in three patients with the Wiskott-Aldrich syndrome, an entity characterized by eczema, thrombocytopenia, and recurrent infections, and inherited in a sex-linked fashion. Blepharoconjunctivitis. associated with molluscum contagiosum, and herpes simplex keratitis, isolated or accompanied by disseminated mucocutaneous herpes simplex virus infection or both, were found. In 18 of the 80 cases of the Wiskott-Aldrich syndrome documented in the literature, ocular complications were present. References 1. Wiskott, A.: Familiärer, angeborener Morbus Werlhofii? , Mschr Kinderheilk 68:212-216 ( (July) ) 1937. 2. Aldrich, R.A.; Steinberg, A.G.; and Campbell, D.C.: Pedigree Demonstrating a Sex-Linked Recessive Condition Characterized by Draining Ears, Eczematoid Dermatitis, and Bloody Diarrhea , Pediatrics 13:133-139 ( (Feb) ) 1954. 3. Wolff, J.A., and Bertucio, M.: A Sex-Linked Genetic Syndrome in a Negro Family Manifested by Thrombocytopenia, Eczema, Bloody Diarrhea, Recurrent Infection. Anemia, and Epistaxis , J Dis Child 93:74 ( (Jan) ) 1957. 4. Huntley, C.C., and Dees, S.C.: Eczema Associated With Thrombocytopenic Purpura and Purulent Otitis Media: Report of Five Fatal Cases , Pediatrics 19:351-361 ( (March) ) 1957. 5. Sansone, G.: Porpora trombopenica del lattante associata a malformazioni multiple ed a spiccata suscettibilità alle infezioni: Rapporti con la sindrome di Aldrich , Minerva Pediat 10:677-684, 1958. 6. Krivit, W., and Good, R.A.: Aldrich's Syndrome (Thrombocytopenia, Eczema, and Infection in Infants): Studies of the Defense Mechanisms , J Dis Child 97:137-153 ( (Feb) ) 1959.Crossref 7. Mills, S.D., and Winkelmann, R.K.: Eczema, Thrombocytopenic Purpura, and Recurring Infections: A Familial Disorder With Report of Four Families , Arch Derm 79:466-472 ( (April) ) 1959.Crossref 8. Midulla, M.: Porpora trombocitopenica associata ad eczema ed infezioni in tre bambini di sesso maschile appartenenti ad una stessa famiglia (sindrome di Aldrich): Comunicazione preliminare , Arch Ital Pediat 20:264-271, 1959. 9. Cummins, L., et al: Aldrich Syndrome in Twins , J Dis Child 98:579-580 ( (Nov) ) 1959. 10. Gordon, R.R.: Aldrich's Syndrome: Familial Thrombocytopenia, Eczema and Infection , Arch Dis Child 35:259-265 ( (June) ) 1960.Crossref 11. Rivera, A.M., and Biehusen, F.C.: Aldrich's Syndrome: Report of a Case With Subperiosteal Hemorrhage , J Pediat 57:86-88 ( (July) ) 1960.Crossref 12. Pierson, M.; Lascombes, G.; and Manciaux, M.: Syndrome d' Aldrich , Sem Hop Paris 36:2630-2632 ( (Oct 24) ) 1960. 13. Eitzman, D.V., and Smith, R.T.: Immunologic Studies on a Patient With Aldrich's Syndrome , Southern Med J 53:1593 ( (Dec) ) 1960. 14. Cassimos, C., et al: Aldrich's Syndrome (Thrombocytopenia, Eczema, and Recurrent Infections): Report of a Case , Amer J Dis Child 100:914-917 ( (Dec) ) 1960.Crossref 15. Coleman, A.; Leiken, S.; and Guin, G.H.: Aldrich's Syndrome , Clin Proc Child Hosp DC 17:22-27 ( (Jan) ) 1961. 16. Kildeberg, P.: The Aldrich Syndrome: Report of a Case and Discussion of Pathogenesis , Pediatrics 27:362-369 ( (March) ) 1961. 17. Gelzer, J., and Gasser, C.: Wiskott-Aldrich Syndrom , Helv Paediat Acta 16:17-39 ( (April) ) 1961. 18. Baker, D.H.; Parmer, E.A.; and Wolff, J.A.: Roentgen Manifestation of the Aldrich Syndrome , Amer J Roentgen 88:458-465 ( (Sept) ) 1962. 19. Gualdoni, C.: Un caso di morbo di Aldrich , Minerva Nipiol 12:370-371, 1962. 20. Root, A.W., and Speicher, C.E.: The Triad of Thrombocytopenia, Eczema, and Recurrent Infections (Wiskott-Aldrich Syndrome) Associated With Milk Antibodies, Giant-Cell Pneumonia, and Cytomegalic Inclusion Disease , Pediatrics 31:444-454 ( (March) ) 1963. 21. Niordson, A., and Schmidt, H.: Aldrich's Syndrome: A Report of Two Cases , Arch Derm 88:613-615 ( (Nov) ) 1963.Crossref 22. Marchal, G., et al: Le syndrome d' Aldrich (purpura thrombopénique familial, eczéma, infections récidivantes) , Presse Med 71:2621-2624 ( (Dec 21) ) 1963. 23. Palmgren, B., and Lindberg, T.: Immunological Studies in Wiskott-Aldrich Syndrome , Acta Paediat , (suppl 146) , pp 116-121, 1963. 24. Weintraub, H.D., and Wilson, W.J.: Pneumocystis carinii Pneumonia in Wiskott-Aldrich Syndrome , Amer J Dis Child 108:198-200 ( (Aug) ) 1964. 25. Johnson, G.M.; Burke, E.C.; and Burgert, E.O., Jr.: Wiskott-Aldrich Syndrome: Report of an Additional Case , Proc Staff Meet Mayo Clin 39:258-262 ( (April) ) 1964. 26. Lanzkowsky, P., and Levy, S.: The Triad of Thrombocytopenia, Eczema and Infection (Wiskott-Aldrich's Syndrome) , S Afr Med J 39:280-282 ( (April 10) ) 1965. 27. Dalloz, J.C., et al: Paraprotéinémie transitoire de type gamma: Observation chez un nourrisson atteint du syndrome d' Aldrich , Presse Med 73:1541-1546 ( (May 26) ) 1965. 28. St. Geme, J.W., Jr., et al: Impaired Cellular Resistance to Herpes-Simplex Virus in Wiskott-Aldrich Syndrome , New Eng J Med 273:229-234 ( (July 29) ) 1965.Crossref 29. Hastrup, J., and Grahl-Madsen, R.: Wiskott-Aldrich's Syndrome: Thrombocytopenia, Eczema and Recurrent Infection , Danish Med Bull 12:99-102 ( (Aug) ) 1965. 30. ten Bensel, R.W.; Stadlan, E.M.; and Krivit, W.: The Development of Malignancy in the Course of the Aldrich Syndrome , J Pediat 68:761-767 ( (May) ) 1966.Crossref 31. Pearson, H.A., et al: Platelet Survival in Wiskott-Aldrich Syndrome , J Pediat 68:754-760 ( (May) ) 1966.Crossref 32. Chaptal, J., et al: Syndrome de Wiskott-Aldrich avec survie prolongee (9 ans): Evolution mortelle par thymosarcome , Arch Franc Pediat 23:907-920 ( (Oct) ) 1966. 33. Kalus, M., and Holub, J.: Aldrich-Wiskott-Syndrome With Thrombocytophagy and Lipopigment in the Reticuloendothelial System , Folia Haemat (Leipzig) 86:164-173, 1966. 34. Wolff, J.A.: Wiskott-Aldrich Syndrome: Clinical, Immunologic, and Pathologic Observations , J Pediat 70:221-232 ( (Feb) ) 1967.Crossref 35. Berglund, G., et al: Wiskott-Aldrich Syndrome: A Study of Six Cases With Determination of the Immunoglobulins A, D, G, M, and ND , Acta Paediat Scand 57:89-97 ( (March) ) 1968.Crossref 36. Cooper, M.D., et al: Wiskott-Aldrich Syndrome: An Immunologic Deficiency Disease Involving the Afferent Limb of Immunity , Amer J Med 44:499-513 ( (April) ) 1968.Crossref 37. Krivit, W.; Yunis, E.; and White, J.G.: Platelet Survival Studies in Aldrich Syndrome , Pediatrics 37:339-341 ( (Feb) ) 1966. 38. Duke-Elder, S.: Diseases of the Outer Eye , System of Ophthalmology , St. Louis: The C. V. Mosby Co., 1965, vol 8, pt 1, pp 310-312. 39. Blaese, R.M., et al: The Wiskott-Aldrich Syndrome: A Disorder With a Possible Defect in Antigen Processing or Recognition , Lancet 1:1056-1061 ( (May 18) ) 1968.Crossref 40. Rosen, F.S., and Janeway, C.A.: The Gamma Globulins: III. The Antibody Deficiency Syndromes , New Eng J Med 275:709-715 ( (Sept 29) ) 1966.Crossref 41. Kretschmer, R., et al: Congenital Aplasia of the Thymus Gland (DiGeorge's Syndrome) , New Eng J Med 279:1295-1301 ( (Dec 12) ) 1968.Crossref

Journal

Archives of OphthalmologyAmerican Medical Association

Published: Sep 1, 1969

References