Opinion EDITORIAL Ongoing Concerns Regarding Finasteride for the Treatment of Male-Pattern Androgenetic Alopecia Roger S. Ho, MD, MS, MPH Since its approval for the treatment of male-pattern androge- in clinical trials. Such was the case with finasteride. The netic alopecia by the United States Food and Drug Adminis- associated reporting bias, along with the lack of power, may tration in 1997, finasteride has continued to be at the center result in many missed associations. Plagued by these biases of many controversies regard- and heterogeneity, even meta-analyses of these clinical trials ing its adverse events. Al- may not provide prescribers a full picture of the drug’s Related article though sexual adverse events adverse events. were included in the original A way to explore the potentially missed adverse events of label of finasteride, little attention was initially paid to the 2002 a drug is through analyzing adverse drug event databases via elimination of the word “all” in the drug monograph regard- a validated pharmacovigilance methodology. The now well- ing sexual adverse events, changing the language from “reso- known risk of a serum sickness–like reaction related to cefa- lution occurred in all men who discontinued therapy” to “reso- clor was identified through
JAMA Dermatology – American Medical Association
Published: Jan 11, 2021
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