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On the Treatment of Panniculitis With Tetracycline

On the Treatment of Panniculitis With Tetracycline Abstract To the Editor.— The relation between "panniculitis," whether localized or generalized, with or without associated pancreatic disease, and lipases has been thought probable for some time. In those reported cases with associated pancreatic diseases, distant foci of subcutaneous fat necrosis and inflammation were attributed to the action of hematogenous-borne lipases.1 That panniculitis is in fact due to the local action of lipase (in conjunction with trypsin and amylase) was elegantly demonstrated in a recent case report by Förström and Winklemann.2 Their patient had an acute, widespread panniculitis. Skin specimens from the lesions showed considerable lipase and amylase activity, as compared with specimens from controls. Autopsy, however, revealed a normal pancreas. Whatever the initiating factors, lipases are likely to play an important role in the pathogenesis of fat necrosis and the subsequent inflammatory reaction of panniculitis.What is the relationship between tetracycline and lipases? In connection with work on References 1. Hughes PSH, Apisamthanarax P, Mullins F: Subcutaneous fat necrosis associated with pancreatic disease . Arch Dermatol 111:506-510, 1975.Crossref 2. Förström L, Winklemann RK: Acute, generalized panniculitis with amylase and lipase in skin . Arch Dermatol 111:497-502, 1975.Crossref 3. Beveridge GW, Powell EW: Sebum changes in acne vulgaris treated with tetracycline . Br J Dermatol 81:825-826, 1969.Crossref 4. Hassing GS: Inhibition of Corynebacterium acnes lipase by tetracycline . J Invest Dermatol 56:189-192, 1971.Crossref 5. Cunliffe WJ, Forster RA, Greenwood ND, et al: Tetracycline and acne vulgaris: A clinical and laboratory investigation . Br Med J 4:332-339, 1973.Crossref 6. Shalita AR, Wheatley V: Inhibition of pancreatic lipase by tetracycline . J Invest Dermatol 54:413-415, 1970.Crossref 7. Chan HL: Panniculitis, with good response to tetracycline . Br J Dermatol 92:315-354, 1975.Crossref 8. Sturman SW, Malkinson FD: Panniculitis: Responsive to high-dose tetracycline therapy . Arch Dermatol 111:533-534, 1975.Crossref 9. Förström L, Winklemann RK: Granulomatous panniculitis in erythema nodosum . Arch Dermatol 111:335-340, 1975.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Dermatology American Medical Association

On the Treatment of Panniculitis With Tetracycline

Archives of Dermatology , Volume 112 (8) – Aug 1, 1976

On the Treatment of Panniculitis With Tetracycline

Abstract

Abstract To the Editor.— The relation between "panniculitis," whether localized or generalized, with or without associated pancreatic disease, and lipases has been thought probable for some time. In those reported cases with associated pancreatic diseases, distant foci of subcutaneous fat necrosis and inflammation were attributed to the action of hematogenous-borne lipases.1 That panniculitis is in fact due to the local action of lipase (in conjunction with trypsin and...
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Publisher
American Medical Association
Copyright
Copyright © 1976 American Medical Association. All Rights Reserved.
ISSN
0003-987X
eISSN
1538-3652
DOI
10.1001/archderm.1976.01630320074027
Publisher site
See Article on Publisher Site

Abstract

Abstract To the Editor.— The relation between "panniculitis," whether localized or generalized, with or without associated pancreatic disease, and lipases has been thought probable for some time. In those reported cases with associated pancreatic diseases, distant foci of subcutaneous fat necrosis and inflammation were attributed to the action of hematogenous-borne lipases.1 That panniculitis is in fact due to the local action of lipase (in conjunction with trypsin and amylase) was elegantly demonstrated in a recent case report by Förström and Winklemann.2 Their patient had an acute, widespread panniculitis. Skin specimens from the lesions showed considerable lipase and amylase activity, as compared with specimens from controls. Autopsy, however, revealed a normal pancreas. Whatever the initiating factors, lipases are likely to play an important role in the pathogenesis of fat necrosis and the subsequent inflammatory reaction of panniculitis.What is the relationship between tetracycline and lipases? In connection with work on References 1. Hughes PSH, Apisamthanarax P, Mullins F: Subcutaneous fat necrosis associated with pancreatic disease . Arch Dermatol 111:506-510, 1975.Crossref 2. Förström L, Winklemann RK: Acute, generalized panniculitis with amylase and lipase in skin . Arch Dermatol 111:497-502, 1975.Crossref 3. Beveridge GW, Powell EW: Sebum changes in acne vulgaris treated with tetracycline . Br J Dermatol 81:825-826, 1969.Crossref 4. Hassing GS: Inhibition of Corynebacterium acnes lipase by tetracycline . J Invest Dermatol 56:189-192, 1971.Crossref 5. Cunliffe WJ, Forster RA, Greenwood ND, et al: Tetracycline and acne vulgaris: A clinical and laboratory investigation . Br Med J 4:332-339, 1973.Crossref 6. Shalita AR, Wheatley V: Inhibition of pancreatic lipase by tetracycline . J Invest Dermatol 54:413-415, 1970.Crossref 7. Chan HL: Panniculitis, with good response to tetracycline . Br J Dermatol 92:315-354, 1975.Crossref 8. Sturman SW, Malkinson FD: Panniculitis: Responsive to high-dose tetracycline therapy . Arch Dermatol 111:533-534, 1975.Crossref 9. Förström L, Winklemann RK: Granulomatous panniculitis in erythema nodosum . Arch Dermatol 111:335-340, 1975.Crossref

Journal

Archives of DermatologyAmerican Medical Association

Published: Aug 1, 1976

References