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ON THE DEMONSTRATION OF VARIATIONS IN THE THYROID COLLOID IN CONDITIONS OF HYPER- AND HYPOTHYROIDISM

ON THE DEMONSTRATION OF VARIATIONS IN THE THYROID COLLOID IN CONDITIONS OF HYPER- AND HYPOTHYROIDISM Abstract The experiments here reported were undertaken in an attempt to demonstrate functional variations of the thyroid. From an analogy with other glands of the body, such variations probably exist in different individuals, and also in the same individual under different conditions. Heretofore there has been no method sufficiently dependable to follow even the extremes of activity of the gland, not to speak of the many possible intermediate stages. Until a satisfactory method is developed, no definite knowledge is obtainable of the true character of the various conditions supposedly referable to abnormal states of the thyroid gland. One of us1 has for a considerable time been interested in the development of a biological test for the thyroid secretion. Attempts are being made to use the cretin rabbit for this purpose, yet by the technic so far employed satisfactory results have not been obtained. The Hunt acetonitril test, though References 1. Tatum, A. L.: Jour. Exper. Med. , 1913, xvii, No. (6) . 2. Carlson, A. J., and Woelfel, A.: Am. Jour. Physiol. , 1910, xxvi, 32. 3. Hunt, Reid: Jour. Am. Med. Assn. , 1907, xlix, 240.Crossref 4. Lussky, H. O.: Am. Jour. Physiol. 1912, xxx, 63. 5. Jones, A. P.: Jour. Exper. Med. , 1913, xvii, No. (5) . 6. The material used was very kindly supplied to us by Parke, Davis & Co., for which we wish to express our appreciation. 7. In this paper we shall use the term "hyperthyroid" reservedly to mean that condition produced directly or indirectly by the feeding of thyroid products. 8. Stoland, O. O.: Am. Jour. Physiol. , 1912, xxx, 37. 9. Brown, W. H.: Jour. Exper. Med. , 1912, xv, No. (6) . http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Internal Medicine American Medical Association

ON THE DEMONSTRATION OF VARIATIONS IN THE THYROID COLLOID IN CONDITIONS OF HYPER- AND HYPOTHYROIDISM

Archives of Internal Medicine , Volume XII (2) – Aug 1, 1913

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Publisher
American Medical Association
Copyright
Copyright © 1913 American Medical Association. All Rights Reserved.
ISSN
0730-188X
DOI
10.1001/archinte.1913.00070020111010
Publisher site
See Article on Publisher Site

Abstract

Abstract The experiments here reported were undertaken in an attempt to demonstrate functional variations of the thyroid. From an analogy with other glands of the body, such variations probably exist in different individuals, and also in the same individual under different conditions. Heretofore there has been no method sufficiently dependable to follow even the extremes of activity of the gland, not to speak of the many possible intermediate stages. Until a satisfactory method is developed, no definite knowledge is obtainable of the true character of the various conditions supposedly referable to abnormal states of the thyroid gland. One of us1 has for a considerable time been interested in the development of a biological test for the thyroid secretion. Attempts are being made to use the cretin rabbit for this purpose, yet by the technic so far employed satisfactory results have not been obtained. The Hunt acetonitril test, though References 1. Tatum, A. L.: Jour. Exper. Med. , 1913, xvii, No. (6) . 2. Carlson, A. J., and Woelfel, A.: Am. Jour. Physiol. , 1910, xxvi, 32. 3. Hunt, Reid: Jour. Am. Med. Assn. , 1907, xlix, 240.Crossref 4. Lussky, H. O.: Am. Jour. Physiol. 1912, xxx, 63. 5. Jones, A. P.: Jour. Exper. Med. , 1913, xvii, No. (5) . 6. The material used was very kindly supplied to us by Parke, Davis & Co., for which we wish to express our appreciation. 7. In this paper we shall use the term "hyperthyroid" reservedly to mean that condition produced directly or indirectly by the feeding of thyroid products. 8. Stoland, O. O.: Am. Jour. Physiol. , 1912, xxx, 37. 9. Brown, W. H.: Jour. Exper. Med. , 1912, xv, No. (6) .

Journal

Archives of Internal MedicineAmerican Medical Association

Published: Aug 1, 1913

References