Abstract The nasal fossa is well supplied with neuroepithelial tissue. Neurogenic tumors of this area are rather uncommon, however, and with the exclusion of benign nasal polyps, are estimated to comprise about 3% of all intranasal tumors.1 One group of such neoplasms forms rather undifferentiated neuroectodermal tissue in histologic patterns similar to those observed in tumors of sympathetic ganglia and the adrenal medulla. Such neoplasms are usually obstructive and locally invasive. Because of their relatively anaplastic nature, they may sometimes be mistaken for undifferentiated epidermoid or adenocarcinoma, lymphosarcoma or malignant melanoma. The preferred generic term for these tumors is olfactory neuroepithelioma. All early reports of this entity were confined to the European literature. It was first described in France in 1924 by Berger, Luc, and Richard, who noted such a lesion in a middle-aged man. They applied the name ésthesioneuroépithéliome olfactif, and mentioned as characteristic features sheets of small rounds References 1. McCormack, L. J., and Harris, H. E.: Neurogenic Tumors of the Nasal Fossa , J. A. M. A. 157:318, 1955.Crossref 2. Seaman, W. B.: Olfactory Esthesioneuro-Epitheliomas , Radiology 57:541, 1951.Crossref 3. Mendeloff, J.: The Olfactory Neuroepithelial Tumors , Cancer 10:944, 1957.Crossref 4. Eggston, A. A., and Wolff, D.: Histopathology of the Ear, Nose, and Throat, Baltimore , Williams & Wilkins Company, 1947, pp. 499 and 512. 5. Willis, R. A.: Pathology of Tumours , St. Louis, The C. V. Mosby Company, 1948, p. 886. 6. Fisher, E. R.: Neuroblastomas of the Nasal Fossa , A. M. A. Arch. Path. 60:435, 1955. 7. Schall, L. A., and Lineback, M.: Primary Intranasal Neuroblastoma , Ann. Otol. Rhin. & Laryng. 60:221, 1951. 8. Frühling, L., and Wild, C.: Olfactory Esthesioneuroepitheliomas of Louis Berger , A. M. A. Arch. Otolaryng. 60:37, 1954. 9. Stout, A. P.: Tumors of the Peripheral Nervous System , in Atlas of Tumor Pathology: Washington, D. C., Armed Forces Institute of Pathology, 1949, Sec. II, Fasc. 6, p. 50. 10. Allen, A. C.: The Skin: A Clinicopathologic Treatise , St. Louis, The C. V. Mosby Company, 1954, pp. 828 and 965.
A.M.A. Archives of Otolaryngology – American Medical Association
Published: Jun 1, 1959