CLINICOPATHOLOGIC REPORT SECTION EDITOR: W. RICHARD GREEN, MD Oculocerebral Non-Hodgkin’s Lymphoma With Uveal Involvement Development of an Epibulbar Tumor After Vitrectomy Claus Cursiefen, MD; Leonard M. Holbach, MD; Bart Lafaut, MD; Klaus Heimann, MD†; Thomas Kirchner, MD; Gottfried O. H. Naumann, MD rimary ocular lymphoma is the ocular manifestation of primary oculocerebral non- Hodgkin’s lymphoma. We describe a 79-year-old woman with a 7-year history of bilat- eral uveitis and subsequent central nervous system lymphomas. Repeated diagnostic vi- P trectomy during the following 5 years failed to demonstrate intraocular lymphoma cells. Within 9 months after the second vitrectomy, an epibulbar tumor developed in the limbal region of the left eye at the site of the sclerotomy. The eye, blind and painful due to secondary angle- closure glaucoma, was enucleated. Histopathologically, the globe showed a diffuse large B-cell non- Hodgkin’s lymphoma extending from the ciliary body outward through the sclerotomy. We con- clude that, following vitrectomy, a primary ocular lymphoma may extend through the sclerotomy lesion and present as an epibulbar tumor. Uveal involvement may occur in oculocerebral non- Hodgkin’s lymphoma. Arch Ophthalmol. 2000;118:1437-1440 Ocular involvement in primary oculocere- itis. In 1986, symptoms of headache and bral non-Hodgkin’s lymphoma often is
JAMA Ophthalmology – American Medical Association
Published: Oct 1, 2000
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