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Oculocerebral Non-Hodgkin's Lymphoma With Uveal Involvement

Oculocerebral Non-Hodgkin's Lymphoma With Uveal Involvement CLINICOPATHOLOGIC REPORT SECTION EDITOR: W. RICHARD GREEN, MD Oculocerebral Non-Hodgkin’s Lymphoma With Uveal Involvement Development of an Epibulbar Tumor After Vitrectomy Claus Cursiefen, MD; Leonard M. Holbach, MD; Bart Lafaut, MD; Klaus Heimann, MD†; Thomas Kirchner, MD; Gottfried O. H. Naumann, MD rimary ocular lymphoma is the ocular manifestation of primary oculocerebral non- Hodgkin’s lymphoma. We describe a 79-year-old woman with a 7-year history of bilat- eral uveitis and subsequent central nervous system lymphomas. Repeated diagnostic vi- P trectomy during the following 5 years failed to demonstrate intraocular lymphoma cells. Within 9 months after the second vitrectomy, an epibulbar tumor developed in the limbal region of the left eye at the site of the sclerotomy. The eye, blind and painful due to secondary angle- closure glaucoma, was enucleated. Histopathologically, the globe showed a diffuse large B-cell non- Hodgkin’s lymphoma extending from the ciliary body outward through the sclerotomy. We con- clude that, following vitrectomy, a primary ocular lymphoma may extend through the sclerotomy lesion and present as an epibulbar tumor. Uveal involvement may occur in oculocerebral non- Hodgkin’s lymphoma. Arch Ophthalmol. 2000;118:1437-1440 Ocular involvement in primary oculocere- itis. In 1986, symptoms of headache and bral non-Hodgkin’s lymphoma often is http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JAMA Ophthalmology American Medical Association

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Publisher
American Medical Association
Copyright
Copyright 2000 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.
ISSN
2168-6165
eISSN
2168-6173
DOI
10.1001/archopht.118.10.1437
Publisher site
See Article on Publisher Site

Abstract

CLINICOPATHOLOGIC REPORT SECTION EDITOR: W. RICHARD GREEN, MD Oculocerebral Non-Hodgkin’s Lymphoma With Uveal Involvement Development of an Epibulbar Tumor After Vitrectomy Claus Cursiefen, MD; Leonard M. Holbach, MD; Bart Lafaut, MD; Klaus Heimann, MD†; Thomas Kirchner, MD; Gottfried O. H. Naumann, MD rimary ocular lymphoma is the ocular manifestation of primary oculocerebral non- Hodgkin’s lymphoma. We describe a 79-year-old woman with a 7-year history of bilat- eral uveitis and subsequent central nervous system lymphomas. Repeated diagnostic vi- P trectomy during the following 5 years failed to demonstrate intraocular lymphoma cells. Within 9 months after the second vitrectomy, an epibulbar tumor developed in the limbal region of the left eye at the site of the sclerotomy. The eye, blind and painful due to secondary angle- closure glaucoma, was enucleated. Histopathologically, the globe showed a diffuse large B-cell non- Hodgkin’s lymphoma extending from the ciliary body outward through the sclerotomy. We con- clude that, following vitrectomy, a primary ocular lymphoma may extend through the sclerotomy lesion and present as an epibulbar tumor. Uveal involvement may occur in oculocerebral non- Hodgkin’s lymphoma. Arch Ophthalmol. 2000;118:1437-1440 Ocular involvement in primary oculocere- itis. In 1986, symptoms of headache and bral non-Hodgkin’s lymphoma often is

Journal

JAMA OphthalmologyAmerican Medical Association

Published: Oct 1, 2000

References

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