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Ocular Neovascularization With Retinal Vascular Occlusion: I. Association With Experimental Retinal Vein Occlusion

Ocular Neovascularization With Retinal Vascular Occlusion: I. Association With Experimental... Abstract • Experimental occlusion of both major temporal retinal veins simultaneously (in six eyes of cynomolgus monkeys) and of the central retinal vein (in one rhesus monkey) produced a fall in intraocular pressure (hypotensive effect) and neovascularization (NV) of the iris and, less frequently, of the optic disc (vasogenic effect). The retinal changes (severity and extent of retinopathy, retinal capillary leakage, and onset and extent of retinal capillary obliteration) were correlated with the pattern of ocular NV and hypotony. No direct correlation was seen between the retinal capillary obliteration and the hypotensive or vasogenic effect. However, a correlation was found between the retinal vascular leakage and the development of ocular NV and hypotony. The pathogeneses of ocular NV and hypotony in retinal vein occlusion are discussed in light of the findings of this study. References 1. Michaelson IC: The mode of development of the vascular system of the retina, with some observations on its significance for certain retinal diseases . Trans Ophthalmol Soc UK 1948;68:137-180. 2. Ashton N, Ward B, Serpell G: Effect of oxygen on developing retinal vessels with particular reference to the problem of retrolental fibroplasia . Br J Ophthalmol 1954;38:397-432.Crossref 3. Wise GN: Retinal neovascularization . Trans Am Ophthalmol Soc 1956;54:729-826. 4. Henkind P: Ocular neovascularization . Am J Ophthalmol 1978;85:287-301. 5. Patz A: Studies on retinal neovascularization . Invest Ophthalmol Vis Sci 1980;19:1133-1138. 6. Hamilton AM, Kohner EM, Rosen D, et al: Experimental venous occlusion . Proc R Soc Med 1974;67:1045-1048. 7. Hamilton AM, Kohner EM, Rosen D, et al: Experimental retinal branch vein occlusion in rhesus monkeys: I. Clinical appearances . Br J Ophthalmol 1979;63:377-387.Crossref 8. Archer DB: Neovascularization of the retina . Trans Ophthalmol Soc UK 1976;96:471-493. 9. Hayreh SS: Experimental allergic encephalomyelitis: II. Retinal and other ocular manifestations . Invest Ophthalmol Vis Sci 1981;21:270-281. 10. Hayreh SS, March W, Phelps CD: Ocular hypotony following retinal vein occlusion . Arch Ophthalmol 1978;96:827-833.Crossref 11. Hayreh SS, van Heuven WAJ, Hayreh MS: Experimental retinal vascular occlusion: I. Pathogenesis of central retinal vein occlusion . Arch Ophthalmol 1978;96:311-323.Crossref 12. Kohner EM, Shilling JS, Hamilton AM: The role of avascular retina in new vessel formation . Metabolic Ophthalmol 1976;1:15-23. 13. Van Heuven WAJ, Hayreh MS, Hayreh SS: Experimental central retinal vascular occlusion—Blood-retinal barrier alterations and retinal lesions . Trans Ophthalmol Soc UK 1977;97:588-618. 14. Cunha-Vaz JG: The blood-ocular barriers . Surv Ophthalmol 1979;23:279-296.Crossref 15. Hayreh SS, Weingeist TA: Experimental occlusion of the central artery of the retina: I. Ophthalmoscopic and fluorescein fundus angiographic studies . Br J Ophthalmol 1980;64:896-912.Crossref 16. Reinecke RD, Kuwabara T, Cogan DG, et al: Retinal vascular patterns: V. Experimental ischemia of the cat eye . Arch Ophthalmol 1962;67:470-475.Crossref 17. Silver IA: Neovascularization in wound healing. Trans Ophthalmol Soc UK, to be published. 18. Hayreh SS, Scott WE: Fluorescein iris angiography: I. Normal pattern . Arch Ophthalmol 1978;96:1383-1389.Crossref 19. Kottow M, Metzler U, Hendrickson P: Iris angiographic findings in retinal vein occlusion , in Cant JS (ed): Vision and Circulation . London, Henry Kimpton Medical Publisher & Bookseller, 1976, pp 251-264. 20. Kottow M, Metzler U, Hendrickson P: Iris angiographic findings in retinal vein occlusion , in Cant JS (ed): Vision and Circulation . London, Henry Kimpton Medical Publisher & Bookseller, 1976, pp 251-264. 21. Hayreh SS: Fluids in the anterior part of the optic nerve in health and disease . Surv Ophthalmol 1978;23:1-25.Crossref 22. Imre G: Studies on the mechanism of retinal neovascularization: Role of lactic acid . Br J Ophthalmol 1964;48:75-82.Crossref 23. Gerke E, Spitznas M, Brodde OE: The role of lactic acid in retinal neovascularization . Albrecht Von Graefes Arch Klin Ophthalmol 1976;200:79-84.Crossref 24. Alexander RW, Kent KM, Pisano JJ, et al: Regulation of post-occlusive hyperemia by endogenously synthesized prostaglandins in the dog heart . J Clin Invest 1975;55:1174-1181.Crossref 25. Collier JG, Herman AG, Vane JR: Appearance of prostaglandins in the renal venous blood of dogs in response to acute systemic hypotension produced by bleeding or endotoxin . J Physiol 1973;230:19-20. 26. Herbaczynska-Cedro K, Vane JR: An intrarenal role for prostaglandin production , in Proceedings of the Fifth International Pharmacological Congress . Basel, Switzerland, S Karger AG, 1975. 27. Herbaczynska-Cedro K, Staszenska-Barczak J, Janczewska H: The release of prostaglandin like substances during reactive and functional hyperemia in the hind leg of the dog . Pol J Pharmacol Pharm 1974;26:167-170. 28. Lewer GP: Role of kinins and prostaglandins as mediators of functional hyperaemia . Proc R Soc Med 1971;64:6-13. 29. Rittenhouse EA, Maixner W, Knott HW, et al: The role of prostaglandin E in the hemodynamic response to aortic clamping and declamping . Surgery 1976;80:137-144. 30. Moncada S, Vane JR: Arachidonic acid metabolites and the interactions between platelets and blood-vessel walls . N Engl J Med 1979;300:1142-1147.Crossref 31. BenEzra D: Neovasculogenic ability of prostaglandins, growth factors, and synthetic chemoattractants . Am J Ophthalmol 1978;86:455-461. 32. Cooper CA, Bergamini MVW, Leopold IH: Use of flurbiprofen to inhibit corneal neovascularization . Arch Ophthalmol 1980;98:1102-1105.Crossref 33. Carroll WW, Geeraets WJ: Diabetic retinopathy and salicylates . Ann Ophthalmol 1972;4:1019-1046. 34. Whitelocke RAF, Eakins KE: Vascular changes in the anterior uvea of the rabbit produced by prostaglandins . Arch Ophthalmol 1973;89:495-499.Crossref 35. Eakins KE: Prostaglandin and non-prostaglandin mediated breakdown of the blood-aqueous barrier . Exp Eye Res 1977;25( (suppl) ):483-498.Crossref 36. Becker B: The mechanism of the fall in intraocular pressure induced by the carbonic anhydrase inhibitor, Diamox . Am J Ophthalmol 1955;39:177-182. 37. Langham ME, Lee PM: Action of Diamox and ammonium chloride on formation of aqueous humor . Br J Ophthalmol 1957;41:65-92.Crossref 38. Cristiansson J: Changes in mucopolysaccharides during alloxan diabetes in the rabbit: II. Studies of intraocular pressure . Acta Ophthalmol 1958;36:163-177.Crossref 39. Wistrand P, Maren TH: The effect of carbonic anhydrase inhibition on intraocular pressure of rabbits with different blood Co2 equilibria . Am J Ophthalmol 1960;50:291-297. 40. Bietti GB, Virno M, Pecori-Giraldi J, et al: Blut-Azidose und Augeninnendruck . Klin Monatsbl Augenheilkd 1972;160:7-12. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Ophthalmology American Medical Association

Ocular Neovascularization With Retinal Vascular Occlusion: I. Association With Experimental Retinal Vein Occlusion

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Publisher
American Medical Association
Copyright
Copyright © 1982 American Medical Association. All Rights Reserved.
ISSN
0003-9950
eISSN
1538-3687
DOI
10.1001/archopht.1982.01030030333024
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Abstract

Abstract • Experimental occlusion of both major temporal retinal veins simultaneously (in six eyes of cynomolgus monkeys) and of the central retinal vein (in one rhesus monkey) produced a fall in intraocular pressure (hypotensive effect) and neovascularization (NV) of the iris and, less frequently, of the optic disc (vasogenic effect). The retinal changes (severity and extent of retinopathy, retinal capillary leakage, and onset and extent of retinal capillary obliteration) were correlated with the pattern of ocular NV and hypotony. No direct correlation was seen between the retinal capillary obliteration and the hypotensive or vasogenic effect. However, a correlation was found between the retinal vascular leakage and the development of ocular NV and hypotony. The pathogeneses of ocular NV and hypotony in retinal vein occlusion are discussed in light of the findings of this study. References 1. Michaelson IC: The mode of development of the vascular system of the retina, with some observations on its significance for certain retinal diseases . Trans Ophthalmol Soc UK 1948;68:137-180. 2. Ashton N, Ward B, Serpell G: Effect of oxygen on developing retinal vessels with particular reference to the problem of retrolental fibroplasia . Br J Ophthalmol 1954;38:397-432.Crossref 3. Wise GN: Retinal neovascularization . Trans Am Ophthalmol Soc 1956;54:729-826. 4. Henkind P: Ocular neovascularization . Am J Ophthalmol 1978;85:287-301. 5. Patz A: Studies on retinal neovascularization . Invest Ophthalmol Vis Sci 1980;19:1133-1138. 6. Hamilton AM, Kohner EM, Rosen D, et al: Experimental venous occlusion . Proc R Soc Med 1974;67:1045-1048. 7. Hamilton AM, Kohner EM, Rosen D, et al: Experimental retinal branch vein occlusion in rhesus monkeys: I. Clinical appearances . Br J Ophthalmol 1979;63:377-387.Crossref 8. Archer DB: Neovascularization of the retina . Trans Ophthalmol Soc UK 1976;96:471-493. 9. Hayreh SS: Experimental allergic encephalomyelitis: II. Retinal and other ocular manifestations . Invest Ophthalmol Vis Sci 1981;21:270-281. 10. Hayreh SS, March W, Phelps CD: Ocular hypotony following retinal vein occlusion . Arch Ophthalmol 1978;96:827-833.Crossref 11. Hayreh SS, van Heuven WAJ, Hayreh MS: Experimental retinal vascular occlusion: I. Pathogenesis of central retinal vein occlusion . Arch Ophthalmol 1978;96:311-323.Crossref 12. Kohner EM, Shilling JS, Hamilton AM: The role of avascular retina in new vessel formation . Metabolic Ophthalmol 1976;1:15-23. 13. Van Heuven WAJ, Hayreh MS, Hayreh SS: Experimental central retinal vascular occlusion—Blood-retinal barrier alterations and retinal lesions . Trans Ophthalmol Soc UK 1977;97:588-618. 14. Cunha-Vaz JG: The blood-ocular barriers . Surv Ophthalmol 1979;23:279-296.Crossref 15. Hayreh SS, Weingeist TA: Experimental occlusion of the central artery of the retina: I. Ophthalmoscopic and fluorescein fundus angiographic studies . Br J Ophthalmol 1980;64:896-912.Crossref 16. Reinecke RD, Kuwabara T, Cogan DG, et al: Retinal vascular patterns: V. Experimental ischemia of the cat eye . Arch Ophthalmol 1962;67:470-475.Crossref 17. Silver IA: Neovascularization in wound healing. Trans Ophthalmol Soc UK, to be published. 18. Hayreh SS, Scott WE: Fluorescein iris angiography: I. Normal pattern . Arch Ophthalmol 1978;96:1383-1389.Crossref 19. Kottow M, Metzler U, Hendrickson P: Iris angiographic findings in retinal vein occlusion , in Cant JS (ed): Vision and Circulation . London, Henry Kimpton Medical Publisher & Bookseller, 1976, pp 251-264. 20. Kottow M, Metzler U, Hendrickson P: Iris angiographic findings in retinal vein occlusion , in Cant JS (ed): Vision and Circulation . London, Henry Kimpton Medical Publisher & Bookseller, 1976, pp 251-264. 21. Hayreh SS: Fluids in the anterior part of the optic nerve in health and disease . Surv Ophthalmol 1978;23:1-25.Crossref 22. Imre G: Studies on the mechanism of retinal neovascularization: Role of lactic acid . Br J Ophthalmol 1964;48:75-82.Crossref 23. Gerke E, Spitznas M, Brodde OE: The role of lactic acid in retinal neovascularization . Albrecht Von Graefes Arch Klin Ophthalmol 1976;200:79-84.Crossref 24. Alexander RW, Kent KM, Pisano JJ, et al: Regulation of post-occlusive hyperemia by endogenously synthesized prostaglandins in the dog heart . J Clin Invest 1975;55:1174-1181.Crossref 25. Collier JG, Herman AG, Vane JR: Appearance of prostaglandins in the renal venous blood of dogs in response to acute systemic hypotension produced by bleeding or endotoxin . J Physiol 1973;230:19-20. 26. Herbaczynska-Cedro K, Vane JR: An intrarenal role for prostaglandin production , in Proceedings of the Fifth International Pharmacological Congress . Basel, Switzerland, S Karger AG, 1975. 27. Herbaczynska-Cedro K, Staszenska-Barczak J, Janczewska H: The release of prostaglandin like substances during reactive and functional hyperemia in the hind leg of the dog . Pol J Pharmacol Pharm 1974;26:167-170. 28. Lewer GP: Role of kinins and prostaglandins as mediators of functional hyperaemia . Proc R Soc Med 1971;64:6-13. 29. Rittenhouse EA, Maixner W, Knott HW, et al: The role of prostaglandin E in the hemodynamic response to aortic clamping and declamping . Surgery 1976;80:137-144. 30. Moncada S, Vane JR: Arachidonic acid metabolites and the interactions between platelets and blood-vessel walls . N Engl J Med 1979;300:1142-1147.Crossref 31. BenEzra D: Neovasculogenic ability of prostaglandins, growth factors, and synthetic chemoattractants . Am J Ophthalmol 1978;86:455-461. 32. Cooper CA, Bergamini MVW, Leopold IH: Use of flurbiprofen to inhibit corneal neovascularization . Arch Ophthalmol 1980;98:1102-1105.Crossref 33. Carroll WW, Geeraets WJ: Diabetic retinopathy and salicylates . Ann Ophthalmol 1972;4:1019-1046. 34. Whitelocke RAF, Eakins KE: Vascular changes in the anterior uvea of the rabbit produced by prostaglandins . Arch Ophthalmol 1973;89:495-499.Crossref 35. Eakins KE: Prostaglandin and non-prostaglandin mediated breakdown of the blood-aqueous barrier . Exp Eye Res 1977;25( (suppl) ):483-498.Crossref 36. Becker B: The mechanism of the fall in intraocular pressure induced by the carbonic anhydrase inhibitor, Diamox . Am J Ophthalmol 1955;39:177-182. 37. Langham ME, Lee PM: Action of Diamox and ammonium chloride on formation of aqueous humor . Br J Ophthalmol 1957;41:65-92.Crossref 38. Cristiansson J: Changes in mucopolysaccharides during alloxan diabetes in the rabbit: II. Studies of intraocular pressure . Acta Ophthalmol 1958;36:163-177.Crossref 39. Wistrand P, Maren TH: The effect of carbonic anhydrase inhibition on intraocular pressure of rabbits with different blood Co2 equilibria . Am J Ophthalmol 1960;50:291-297. 40. Bietti GB, Virno M, Pecori-Giraldi J, et al: Blut-Azidose und Augeninnendruck . Klin Monatsbl Augenheilkd 1972;160:7-12.

Journal

Archives of OphthalmologyAmerican Medical Association

Published: Feb 1, 1982

References