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Ocular Manifestations of Ethambutol: Toxic Amblyopia After Administration of an Experimental Antituberculous Drug

Ocular Manifestations of Ethambutol: Toxic Amblyopia After Administration of an Experimental... Abstract Introduction Ethambutol* (2,2'-(ethylenediamino) di1-butanol) is an experimental drug which shows promise against resistant tubercle bacilli. It has been used experimentally in patients refractory to all other antituberculous medication. To date, 18 patients have been placed on the drug in various centers throughout the country. They received dosages varying from 60 to 100 mg. per kilogram body weight per day. Eight of these patients developed either mild or severe toxic amblyopia. The following case demonstrates the features of the ocular toxicity of ethambutol. Report of a Case The patient, a 49-year-old white male, was admitted on March 9, 1961, with tuberculosis resistant to streptomycin, isoniazid (INH), and aminosalicylic acid (PAS). He has been known to have diabetes since April, 1960. The patient smokes 1½ packages of cigarettes a day and is a chronic alcoholic. The past history is otherwise negative. Physical Examination. —Vital signs were normal. The trachea was deviated to References 1. Lederle Laboratories, Pearl River, N.Y. 2. Carroll, F. D.: Toxic Amblyopia, in Symposium: Diseases of the Optic Nerve , Trans. Amer. Acad. Ophthal. Otolaryng. 60:74, 1956. 3. Walsh, F. B.: Clinical Neuro-Ophthalmology , Ed. 2, Baltimore, The Williams & Wilkins Company, 1957, p. 706. 4. Henderson, J. W.: Generalized Infectious Diseases, in Symposium: Diseases of the Optic Nerve , Trans. Amer. Acad. Ophthal. Otolaryng. 60:68, 1956. 5. Waite, J. H., and Beetham, W. P.: The Visual Mechanism in Diabetes Mellitus: Comparative Study of 2002 Diabetics and 457 Non-Diabetics for Control , New Engl. J. Med. 212: 367-379, 429-433, 1935.Crossref 6. Harrington, D. O.: The Visual Fields , St. Louis, The C. V. Mosby Company, 1956, pp. 162 and 196. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Ophthalmology American Medical Association

Ocular Manifestations of Ethambutol: Toxic Amblyopia After Administration of an Experimental Antituberculous Drug

CARR, RONALD E.; HENKIND, PAUL
Archives of Ophthalmology , Volume 67 (5) – May 1, 1962
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Publisher
American Medical Association
Copyright
Copyright © 1962 American Medical Association. All Rights Reserved.
ISSN
0003-9950
eISSN
1538-3687
DOI
10.1001/archopht.1962.00960020566009
Publisher site
See Article on Publisher Site

Abstract

Abstract Introduction Ethambutol* (2,2'-(ethylenediamino) di1-butanol) is an experimental drug which shows promise against resistant tubercle bacilli. It has been used experimentally in patients refractory to all other antituberculous medication. To date, 18 patients have been placed on the drug in various centers throughout the country. They received dosages varying from 60 to 100 mg. per kilogram body weight per day. Eight of these patients developed either mild or severe toxic amblyopia. The following case demonstrates the features of the ocular toxicity of ethambutol. Report of a Case The patient, a 49-year-old white male, was admitted on March 9, 1961, with tuberculosis resistant to streptomycin, isoniazid (INH), and aminosalicylic acid (PAS). He has been known to have diabetes since April, 1960. The patient smokes 1½ packages of cigarettes a day and is a chronic alcoholic. The past history is otherwise negative. Physical Examination. —Vital signs were normal. The trachea was deviated to References 1. Lederle Laboratories, Pearl River, N.Y. 2. Carroll, F. D.: Toxic Amblyopia, in Symposium: Diseases of the Optic Nerve , Trans. Amer. Acad. Ophthal. Otolaryng. 60:74, 1956. 3. Walsh, F. B.: Clinical Neuro-Ophthalmology , Ed. 2, Baltimore, The Williams & Wilkins Company, 1957, p. 706. 4. Henderson, J. W.: Generalized Infectious Diseases, in Symposium: Diseases of the Optic Nerve , Trans. Amer. Acad. Ophthal. Otolaryng. 60:68, 1956. 5. Waite, J. H., and Beetham, W. P.: The Visual Mechanism in Diabetes Mellitus: Comparative Study of 2002 Diabetics and 457 Non-Diabetics for Control , New Engl. J. Med. 212: 367-379, 429-433, 1935.Crossref 6. Harrington, D. O.: The Visual Fields , St. Louis, The C. V. Mosby Company, 1956, pp. 162 and 196.

Journal

Archives of Ophthalmology – American Medical Association

Published: May 1, 1962

References

  • Toxic Amblyopia, in Symposium: Diseases of the Optic Nerve
    Carroll , F. D.
  • Clinical Neuro-Ophthalmology
    Walsh , F. B.
  • Generalized Infectious Diseases, in Symposium: Diseases of the Optic Nerve
    Henderson , J. W.
  • The Visual Mechanism in Diabetes Mellitus: Comparative Study of 2002 Diabetics and 457 Non-Diabetics for Control
    Waite , J. H., and Beetham, W. P.
  • The Visual Fields
    Harrington , D. O.